|Official Full Name||proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)|
|Background||The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.|
|Synonyms||PSMB8; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); LMP7, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7); proteasome subunit beta type-8; beta5i; D6S216E; PSMB5i; RIN|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PSMB8 involved in several pathways and played different roles in them. We selected most pathways PSMB8 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Proteasome||PSMD4A; PSMD13; IFNG; PSMB11; PSMB8F; PSMD4; PSMB5; PSMB3; PSME2; PSMB1|
PSMB8 has several biochemical functions, for example, endopeptidase activity, protein binding, threonine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMB8 itself. We selected most functions PSMB8 had, and list some proteins which have the same functions with PSMB8. You can find most of the proteins on our site.
|endopeptidase activity||CTSH; Ren1; PSMB10; KLK1B24; PARL; KLK1B11; CD46; PCSK6; APH1C; REN2|
|protein binding||SLC38A2; TSEN2; PTPLAD1; KMT2E; CDK10; GPSM1; LSAMP; LRP6; TUBA1A; SFRP1|
|threonine-type endopeptidase activity||PSMB3; PSMB4; PSMA6A; PSMB8F; PSMB11; PRSS50; PSMA6; PSMB1; PSMA7; PSMA8|
PSMB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMB8.
p27958-pro_0000037573; LSM1; TAP1; TAP2; q7cfv5_yerpe; q81z98_bacan; PSMB7