ran
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  • Official Full Name
  • RAN RAN, member RAS oncogene family
  • Background
  • Ran (rasrelated nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleuscytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RanGTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedys disease (Xlinked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease.
  • Synonyms
  • RAN; RAN, member RAS oncogene family; GTP-binding nuclear protein Ran; ARA24; Gsp1; TC4; RanGTPase; GTPase Ran; OK/SW-cl.81; ras-like protein TC4; member RAS oncogene family; ras-related nuclear protein; guanosine triphosphatase Ran; androgen receptor-associated protein 24
Cat.#:RAN-1125HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN, Member RAS Oncogene Family
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Cat.#:RAN-17HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN protein, His-tagged
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Cat.#:RAN-18HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN protein, His-tagged, Human wild type.
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Cat.#:RAN-2173HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN, GST-tagged
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Cat.#:RAN-2582HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN, Member RAS Oncogene Family, His-tagged
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Cat.#:RAN-716HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN (T24N) Protein
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Cat.#:RAN-717HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN (Q69L) Protein
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Cat.#:RAN-718HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN (G19V/Q69L) Protein
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Cat.#:RAN-719HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN (E70A) Protein
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Cat.#:RAN-13908MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAN Protein
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Cat.#:RAN-4922RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAN Protein
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Cat.#:RAN-843CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RAN Protein, His-tagged
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Cat.#:RAN-3780RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RAN Protein, His-tagged
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Cat.#:RAN-6810CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAN
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Cat.#:RAN-8896ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAN
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Cat.#:RAN-2535HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAN 293 Cell Lysate
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Involved Pathway

RAN involved in several pathways and played different roles in them. We selected most pathways RAN participated on our site, such as Ribosome biogenesis in eukaryotes, RNA transport, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome biogenesis in eukaryotes
FCF1; XPO1; CSNK2A2A; ACK2; GNL2; NXT1; RPP25L; WDR36; RCL1; NOP56
RNA transport
SUMO3B; MAGOHB; EIF2B4; RANBP2; NUP93; PNN; PAIP1; EIF4E2; SUMO2B; THOC2
HTLV-I infection
WNT2B; WNT4; PDGFB; BCL2L1; HLA-G; RANBP3; LTA; HLA-B; WNT3; VDAC2
Epstein-Barr virus infection
TP53; HSPA1L; EP300; YWHAH; ICAM1; PSMC3; TRADD; SKP2; HLA-E; PSMD4

Protein Function

RAN has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAN itself. We selected most functions RAN had, and list some proteins which have the same functions with RAN. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein RAP2C; PRPS1; ARL8B; RAB27A; SRP54B; RRAGC; RAB3B; RAB22A; RAB17; RHOA
Function GTP binding
Related Protein GEM; GNAI2B; RAP2AB; GSPT1L; KRAS; RAB35B; ARL4CA; TUBE1; RHOQ; RP2
Function GTPase activity
Related Protein NKIRAS1; RAB39A; GBP2; TUBA3C; RAB3D; RRAGC; RAB27B; ATL3; GNAO1; RABL2
Function androgen receptor binding
Related Protein DAXX; CTNNB1; DDX5; RB1; EP300; PRPF6; CCNE1; RNF14; PIAS1; FHL2
Function chromatin binding
Related Protein ING2; TICRR; EGFR; NCOA2; URI1; RELB; PRKCB; PYGO2; SKIL; CREB3L1
Function dynein intermediate chain binding
Related Protein HTT; HEATR2; PAFAH1B1; RAN
Function importin-alpha family protein binding
Related Protein TPX2; GOLGA2; RAN
Function poly(A) RNA binding
Related Protein NCL; ANXA11; PDIA3; NOP16; NOC2L; FNDC3B; RBMX2; NOA1; RPF1; MRPL4
Function contributes_to pre-miRNA binding
Related Protein RAN; TARBP2; XPO5; DICER1
Function protein binding
Related Protein CXADR; RPS11; TMIGD2; SPTSSA; ACTR6; CDKN2A; SEMA4A; GABARAPL2; ASCL4; NDUFB9
Function protein complex binding
Related Protein TRADD; OTOF; ING2; NDUFA8; CRTAP; EPHB1; BCAP31; IGBP1; NCOA1; Cel
Function protein domain specific binding
Related Protein TACC2; TRP63; YWHAQA; DVL2; YWHABL; TNFAIP1; RAB27B; TWIST1; RUNX2; CEP68
Function transcription coactivator activity
Related Protein TFAP2B; BRCA1; RUNX1; RB1; NR1I2; NR1H4; ESRRB; MED13; TADA2B; SMARCB1

Interacting Protein

RAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAN here. Most of them are supplied by our site. Hope this information will be useful for your research of RAN.
gdp; RCC1; IPO13

RAN Related Articles

Gulka, CP; Swartz, JD; et al. Ni(II)NTA AuNPs as a low-resource malarial diagnostic platform for the rapid colorimetric detection of Plasmodium falciparum Histidine-Rich Protein-2. TALANTA 135:94-101(2015).
Qu, HH; Wang, Y; et al. Development of ELISA for detection of Rh1 and Rg2 and potential method of immunoaffinity chromatography for separation of epimers. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 985:197-205(2015).