RAN

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RAN

Official Full Name RAN RAN, member RAS oncogene family
Background Ran (rasrelated nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleuscytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RanGTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedys disease (Xlinked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease.
Synonyms RAN; RAN, member RAS oncogene family; GTP-binding nuclear protein Ran; ARA24; Gsp1; TC4; RanGTPase; GTPase Ran; OK/SW-cl.81; ras-like protein TC4; member RAS oncogene family; ras-related nuclear protein; guanosine triphosphatase Ran; androgen receptor-associated protein 24
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RAN-065H Recombinant Human RAN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Ran-5364M Recombinant Mouse Ran Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human RAN-1125H Recombinant Human RAN, Member RAS Oncogene Family E.coli N/A
    Human RAN-17H Recombinant Human RAN protein, His-tagged E.coli His
    Human RAN-18H Recombinant Human RAN protein, His-tagged, Human wild type. E.coli His
    Human RAN-2173H Recombinant Human RAN, GST-tagged E.coli GST
    Human RAN-2535HCL Recombinant Human RAN 293 Cell Lysate HEK293 N/A
    Human RAN-2582H Recombinant Human RAN, Member RAS Oncogene Family, His-tagged E.coli His
    Human RAN-716H Recombinant Human RAN (T24N) Protein E.coli N/A
    Human RAN-717H Recombinant Human RAN (Q69L) Protein E.coli N/A
    Human RAN-718H Recombinant Human RAN (G19V/Q69L) Protein E.coli N/A
    Human RAN-719H Recombinant Human RAN (E70A) Protein E.coli N/A
    Mouse RAN-13908M Recombinant Mouse RAN Protein Mammalian Cell His
    Rat RAN-4922R Recombinant Rat RAN Protein Mammalian Cell His
    Cynomolgus Monkey RAN-843C Recombinant Cynomolgus RAN Protein, His-tagged Mammalian Cell His
    Rhesus Macaque RAN-3780R Recombinant Rhesus monkey RAN Protein, His-tagged Mammalian Cell His
    Chicken RAN-6810C Recombinant Chicken RAN Mammalian Cell His
    Zebrafish RAN-8896Z Recombinant Zebrafish RAN Mammalian Cell His

    RAN involved in several pathways and played different roles in them. We selected most pathways RAN participated on our site, such as Ribosome biogenesis in eukaryotes, RNA transport, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome biogenesis in eukaryotes NVL; FBLL1; SMFN; cka1; TCOF1; PWP2H; RRP7A; DROSHA; NXF1; MPHOSPH10
    RNA transport NUP85; SNUPN; EIF3C; SMN; MAGOH2; RPP21; EIF1AY; EIF2S2; PABPC1L; CYFIP2
    HTLV-I infection VDAC2; PDGFA; HLA-DQA2; PIK3R2; HLA-DMA; WNT8A; TNFRSF13C; WNT3A; TRP53; TP53INP1
    Epstein-Barr virus infection SNW1; YWHAZ; HDAC2; IKBKG; PIK3CB; POLR3F; SYK; MAPK10; MAP2K6; POLR2J3

    RAN has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAN itself. We selected most functions RAN had, and list some proteins which have the same functions with RAN. You can find most of the proteins on our site.

    Function Related Protein
    GDP binding PRPS1; PIGC; MIEF1; RAB18; RAB10; RAB7A; SRP54A; RAB17; RAB5C; SEPT12
    GTP binding EHD2; GNAZ; ARF5; DIRAS1A; ARL8BA; RAB39BB; ARL5C; RALAA; GLUD1; DIRAS1B
    GTPase activity RAB40AL; RHOQ; GNAIA; GNL3; IRGF1; TUBB; RASEF; RAN; RAB23; GNB2
    androgen receptor binding NSD1; TRIM68; KDM3A; CCNE1; BRCA1; NCOA1; NCOA3; PARK7; RAN; EP300
    chromatin binding ATAD2B; ARID3A; SMARCC1; CAPNS2; NAP1L2; GM606; PDX1; POLR2B; MBD5; EP300
    dynein intermediate chain binding HTT; RAN; PAFAH1B1; HEATR2
    importin-alpha family protein binding TPX2; RAN; GOLGA2
    poly(A) RNA binding CPEB4; DDX39A; ASCC3; SRSF9; SARS2; DKC1; MEX3B; CNOT1; DDX50; EXOSC8
    contributes_to pre-miRNA binding DICER1; RAN; XPO5; TARBP2
    protein binding AGER; HOMER3; POLH; MAL2; NME7; STAG2; KLC4; CD300LD; PHF15; NOTCH1
    protein complex binding PRMT5; FLCN; PPP1R9B; ITPR1; ERCC8; Apba1; GIT1; KRIT1; RIPK1; PPARA
    protein domain specific binding SCAF1; TBL1X; TRIM11; WNT1; IL1B; MED12; ARR3; DDX20; NFASC; DYNLL1
    transcription coactivator activity SMARCB1; MTDH; RAN; NR1H4; NPM1; SNW1; CBFB; KDM5A; MED17; NFE2

    RAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAN here. Most of them are supplied by our site. Hope this information will be useful for your research of RAN.

    gdp; RCC1; IPO13

    Gulka, CP; Swartz, JD; et al. Ni(II)NTA AuNPs as a low-resource malarial diagnostic platform for the rapid colorimetric detection of Plasmodium falciparum Histidine-Rich Protein-2. TALANTA 135:94-101(2015).
    Qu, HH; Wang, Y; et al. Development of ELISA for detection of Rh1 and Rg2 and potential method of immunoaffinity chromatography for separation of epimers. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 985:197-205(2015).

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