ranbp2
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  • Official Full Name
  • RAN binding protein 2
  • Background
  • RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RANBP2; RAN binding protein 2; ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358; E3 SUMO-protein ligase RanBP2; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ran-binding protein 2; transformation-related protein 2; nuclear pore complex protein Nup358; acute necrotizing encephalopathy 1 (autosomal dominant);
Cat.#:RANBP2-2386HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAN Binding Protein 2, GST-tagged
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Cat.#:RANBP2-13912MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RANBP2 Protein
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Involved Pathway

RANBP2 involved in several pathways and played different roles in them. We selected most pathways RANBP2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANBP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
POP4; EIF4EBP3L; WIBG; POM121L2; EIF1AXB; EIF2B5; TACC3; MAGOH; PABPC3; NUP62L

Protein Function

RANBP2 has several biochemical functions, for example, RNA binding, Ran GTPase binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RANBP2 itself. We selected most functions RANBP2 had, and list some proteins which have the same functions with RANBP2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein HNRNPUL1; EXOSC6; CNOT7; BICC2; PDCD4; KIN; ZFP385C; UBR5; SFPI1; RPL38
Function Ran GTPase binding
Related Protein RANGAP1; RANBP10; XPO6; BIRC5; XPOT; RANBP1; TNPO2; CSE1L; KPNB1; IPO13
Function ligase activity
Related Protein UCHL1; RNF4; RNF220; UBE1Y1; KCMF1; ARIH1L; TRIP12; TNFAIP3; SYVN1; RNF114
Function peptidyl-prolyl cis-trans isomerase activity
Related Protein PIN4; PPIFB; FKBP2; PPIE; FKBP7; PPIL2; PPIAL4C; FKBP6; FKBP1B; FKBP10
Function protein binding
Related Protein E2F3; CD274; RBP4; SCNN1D; PIN4; SLC16A3; YIF1A; ACTL6A; OTUD7B; TIMP1
Function protein complex binding
Related Protein PLK2; RIPK3; BCAP31; DAG1; AP2A1; ATF1; UFD1L; Ctsl; RPAIN; MTAP1B
Function zinc ion binding
Related Protein CNBP; NR6A1; S100B; TRIM26; APOBEC3B; ADAM10A; ADAM17A; RNF139; ZDHHC2; RNF169

Interacting Protein

RANBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANBP2.
UBE2I; PARK2; RAN; NXF1; ERBB2

RANBP2 Related Articles

Senecal, JL; Isabelle, C; et al. An Autoimmune Myositis-Overlap Syndrome Associated With Autoantibodies to Nuclear Pore Complexes Description and Long-Term Follow-up of the Anti-Nup Syndrome. MEDICINE 93:361-372(2014).
Splinter, D; Tanenbaum, ME; et al. Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry. PLOS BIOLOGY 8:-(2010).