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Official Full Name RAN binding protein 2
Background RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Synonyms RANBP2; RAN binding protein 2; ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358; E3 SUMO-protein ligase RanBP2; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ran-binding protein 2; transformation-related protein 2; nuclear pore complex protein Nup358; acute necrotizing encephalopathy 1 (autosomal dominant);
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RANBP2-2250H Recombinant Human RANBP2 Protein (2601-2802 aa), His-tagged Yeast His
    Human RANBP2-2386H Recombinant Human RANBP2 Protein, GST-tagged E.coli GST
    Mouse RANBP2-13912M Recombinant Mouse RANBP2 Protein Mammalian Cell His

    RANBP2 involved in several pathways and played different roles in them. We selected most pathways RANBP2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport EIF5; ELAC1; EIF2B2; PABPC1L; NCBP1; NUP188; RAN; RNPS1; DDX20; PABPC5

    RANBP2 has several biochemical functions, for example, RNA binding, Ran GTPase binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RANBP2 itself. We selected most functions RANBP2 had, and list some proteins which have the same functions with RANBP2. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding RPL14; HNRNPA1L2; HNRPL; PPIE; LIN28B; NHP2L1; RCL1; Akap17b; PTBP1A; CTIF
    Ran GTPase binding IPO5; XPO7; DPY19L2; NXT1; XPOT; NUTF2; IPO4; XPO6; XPO1; RANGAP1
    ligase activity RNF4; UBR5; SH3RF1; TRIM17; MARCH11; LTN1; DTX3; UBE2D1A; ARIH2; HECW1B
    peptidyl-prolyl cis-trans isomerase activity FKBP1A; PPIL1; PPIC; FKBPL; PPIH; PPWD1; FKBP9; PPIAB; FKBP10B; PIN1
    protein binding RBP5; TTC17; STX16; CD209; CA4; C2orf51; GNS; FAM129A; TWIST2; PKIA
    protein complex binding CDK4; VHLL; LCK; LRP2; MYO7A; Apba1; VAMP2; TAB1; KRAS; RAP1B
    zinc ion binding Car9; LHX1A; CXXC4; SEC24C; SUPT4H1; BBOX1; AGBL5; TCF19; RABGGTB; SERPINB1A

    RANBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANBP2.


    Senecal, JL; Isabelle, C; et al. An Autoimmune Myositis-Overlap Syndrome Associated With Autoantibodies to Nuclear Pore Complexes Description and Long-Term Follow-up of the Anti-Nup Syndrome. MEDICINE 93:361-372(2014).
    Splinter, D; Tanenbaum, ME; et al. Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry. PLOS BIOLOGY 8:-(2010).

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