Recombinant Human RANBP2 Protein (2601-2802 aa), His-tagged

• Cat.No.: RANBP2-2250H
• Product Overview: Recombinant Human RANBP2 Protein (2601-2802 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.

Specification

• Description: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 24.8 kDa
• Protein length: 2601-2802 aa
• AA Sequence: PTEESSINYTFKTPEKAKEKKKPED SPSDDDVLIVYELTPTAEQKALATK LKLPPTFFCYKNRPDYVSEEEEDDE DFETAVKKLNGKLYLDGSEKCRPLE ENTADNEKECIIVWEKKPTVEEKAK ADTLKLPPTFFCGVCSDTDEDNGNG EDFQSELQKVQEAQKSQTEEITSTT DSVYTGGTEVMVPSFCKSEEPDSIT KS
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: RANBP2 RAN binding protein 2 [ Homo sapiens ]
• Official Symbol: RANBP2
• Synonyms: RANBP2; NUP358; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ANE1; TRP1; TRP2; IIAE3
• Gene ID: 5903
• mRNA Refseq: NM_006267
• Protein Refseq: NP_006258
• MIM: 601181
• UniProt ID: P49792