RPSA

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RPSA

Official Full Name ribosomal protein SA
Background Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms RPSA; ribosomal protein SA; laminin receptor 1 (67kD, ribosomal protein SA) , LAMR1; 40S ribosomal protein SA; 37LRP; LRP; p40; SA; 34/67 kDa laminin receptor; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 67 kDa laminin receptor; 67LR; Colon carcinoma laminin binding protein; Colon carcinoma laminin-binding protein; LAMBR; Laminin Receptor 1; Laminin-binding protein precursor p40; LAMR 1; LamR; LAMR1; LBP/p40; LRP/LR; Multidrug resistance associated protein MGr1 Ag; Multidrug resistance associated protein MGr1Ag; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; RSSA_HUMAN; 37 kDa laminin receptor; laminin binding protein; 67kD, ribosomal protein SA; laminin receptor 1 (67kD,; LBP
    • Species :
    • Bacillus subtilis
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli or Yeast
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • His
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RPSA-2508H Recombinant Human RPSA Protein (2-294 aa), His-tagged Yeast His
    Human RPSA-2595H Recombinant Human RPSA Protein (2-295 aa), His-Myc-tagged E.coli His/Myc
    Human RPSA-2745H Recombinant Human RPSA Protein (2-295 aa), His-MBP-tagged Insect Cell His/Myc
    Human RPSA-2154HCL Recombinant Human RPSA 293 Cell Lysate HEK293 N/A
    Human RPSA-2155HCL Recombinant Human RPSA 293 Cell Lysate HEK293 N/A
    Human RPSA-26030TH Recombinant Human RPSA Wheat Germ N/A
    Human RPSA-26032TH Recombinant Human RPSA Wheat Germ N/A
    Human RPSA-P023H Recombinant Human RPSA therapeutic protein N/A
    Mouse RPSA-14506M Recombinant Mouse RPSA Protein Mammalian Cell His
    Rat RPSA-5175R Recombinant Rat RPSA Protein Mammalian Cell His
    Rhesus Macaque RPSA-4032R Recombinant Rhesus monkey RPSA Protein, His-tagged Mammalian Cell His
    Chicken RPSA-1749C Recombinant Chicken RPSA Mammalian Cell His
    Zebrafish RPSA-11280Z Recombinant Zebrafish RPSA Mammalian Cell His
    Bacillus subtilis RPSA-1146B Recombinant Bacillus subtilis RPSA protein, His-tagged E. coli or Yeast His

    RPSA involved in several pathways and played different roles in them. We selected most pathways RPSA participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPSA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome RPS27.1; RPLP1; MRPS10; RPL36A; RPS26; MRPS18C; MRPL11; RPL39; RPLP2; RPL28

    RPSA has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by RPSA itself. We selected most functions RPSA had, and list some proteins which have the same functions with RPSA. You can find most of the proteins on our site.

    Function Related Protein
    laminin binding THBS1; PLEKHA2; NID1; ECM1; ACHE; LYPD5; LGALS2A; BCAM; LYPD3; ITGA7
    laminin receptor activity RPSA; BCAM
    poly(A) RNA binding RPS4Y2; DCD; FSCN1; TBCA; LARP4B; HMGB3; APEX1; CDKN2A; ARHGEF1; HIST1H4C
    protein binding PTPN4; TLR4; SIRPG; CTBP2; ITGB1BP3; RANBP6; SLC30A1; SORT1; CRTC2; SEPT11
    ribosome binding SBDS; CPEB2; EIF5A2; NAA16; NARG1; MTRF1L; CPEB1; EIF2S1B; ETF1; CPEB1A
    structural constituent of ribosome MRPL35; RPL7; RPL35A; MRPS18B; RPS8; MRPS30; MRPS6; SLC25A24L; RPL39L; MRPS18C
    virus receptor activity IDE; NCAM1; CD46; CLDN1; SCARB1; ITGAV; TYRO3; EFNB2; CCR5; ITGA2

    RPSA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPSA here. Most of them are supplied by our site. Hope this information will be useful for your research of RPSA.

    KARS; TINF2; CALM1; PCNA; ACTB; DCTN6; HSPB1; TFAP2A; PROS1; SLC2A5; ABCD1; ACADVL; RPS21; HBG2

    Zidane, N; Ould-Abeih, MB; et al. The folded and disordered domains of human ribosomal protein SA have both idiosyncratic and shared functions as membrane receptors. BIOSCIENCE REPORTS 33:113-124(2013).
    Ould-Abeih, MB; Petit-Topin, I; et al. Multiple Folding States and Disorder of Ribosomal Protein SA, a Membrane Receptor for Laminin, Anticarcinogens, and Pathogens. BIOCHEMISTRY 51:4807-4821(2012).

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