rpsa
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  • Official Full Name
  • ribosomal protein SA
  • Background
  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • RPSA; ribosomal protein SA; laminin receptor 1 (67kD, ribosomal protein SA) , LAMR1; 40S ribosomal protein SA; 37LRP; LRP; p40; SA; 34/67 kDa laminin receptor; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 67 kDa laminin receptor; 67LR; Colon carcinoma laminin binding protein; Colon carcinoma laminin-binding protein; LAMBR; Laminin Receptor 1; Laminin-binding protein precursor p40; LAMR 1; LamR; LAMR1; LBP/p40; LRP/LR; Multidrug resistance associated protein MGr1 Ag; Multidrug resistance associated protein MGr1Ag; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; RSSA_HUMAN; 37 kDa laminin receptor; laminin binding protein; 67kD, ribosomal protein SA; laminin receptor 1 (67kD,; LBP
Cat.#:RPSA-26030THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RPSA
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Cat.#:RPSA-26032THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RPSA
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Cat.#:RPSA-14506MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPSA Protein
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Cat.#:RPSA-5175RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPSA Protein
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Cat.#:RPSA-4032RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RPSA Protein, His-tagged
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Cat.#:RPSA-1749CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPSA
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Cat.#:RPSA-11280ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPSA
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Cat.#:RPSA-1146BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis RPSA protein, His-tagged
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Cat.#:RPSA-2154HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RPSA 293 Cell Lysate
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Cat.#:RPSA-2155HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RPSA 293 Cell Lysate
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Cat.#:RPSA-P023HTag:
Source (Host):Species:Human
Product nameRecombinant Human RPSA therapeutic protein
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Involved Pathway

RPSA involved in several pathways and played different roles in them. We selected most pathways RPSA participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPSA were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome
MRPS12; MRPL20; RPS18; RPL27; RPSA; RPL3L; RPL36A-HNRNPH2; RPLP1; RPL9; RPS12

Protein Function

RPSA has several biochemical functions, for example, laminin binding, laminin receptor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPSA itself. We selected most functions RPSA had, and list some proteins which have the same functions with RPSA. You can find most of the proteins on our site.
Function
Related Protein
Function laminin binding
Related Protein PLEKHA2; BCAM; CTSS; ITGA3; LGALS1; LGALS2A; ADAM9; GPC1; LGALS3; RPSA
Function laminin receptor activity
Related Protein BCAM; RPSA
Function poly(A) RNA binding
Related Protein SF3A3; SRSF3; EIF4A3; RBM12; ILF3; PRPF3; RPL19; RPS23; WDR46; SRSF5
Function protein binding
Related Protein CCT5; RMI1; PIH1D2; SYT1; SNX33; BBS12; TOX4; EXD1; CDK2; NUP153
Function ribosome binding
Related Protein C12orf65; RICTOR; EIF5A; CPEB2; BAG6; IGHMBP2; SBDS; EIF6; YTHDF1; SEC61A1
Function structural constituent of ribosome
Related Protein MRPS17; RPS3; MRPL52; RPL27; RPS2; MRPL42; RPL12; MRPS31; MRPL19; MRPS22
Function virus receptor activity
Related Protein DAG1; CD4; SCARB2; ITGB5; LDLR; MRC1; HSPA1A; ITGAV; HYAL2; GPR172B

Interacting Protein

RPSA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPSA here. Most of them are supplied by our site. Hope this information will be useful for your research of RPSA.
KARS; TINF2; CALM1; PCNA; ACTB; DCTN6; HSPB1; TFAP2A; PROS1; SLC2A5; ABCD1; ACADVL; RPS21; HBG2

RPSA Related Articles

Zidane, N; Ould-Abeih, MB; et al. The folded and disordered domains of human ribosomal protein SA have both idiosyncratic and shared functions as membrane receptors. BIOSCIENCE REPORTS 33:113-124(2013).
Ould-Abeih, MB; Petit-Topin, I; et al. Multiple Folding States and Disorder of Ribosomal Protein SA, a Membrane Receptor for Laminin, Anticarcinogens, and Pathogens. BIOCHEMISTRY 51:4807-4821(2012).