Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339);and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not;result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM;602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from;degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino;acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL;precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins;(Kim et al., 2000 (PubMed 10799485)). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated;substrates (Lima and Reverter, 2008 (PubMed 18799455)).
SENP6 has several biochemical functions, for example, SUMO-specific protease activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP6 itself. We selected most functions SENP6 had, and list some proteins which have the same functions with SENP6. You can find most of the proteins on our site.
Function SUMO-specific protease activity
Related Protein SENP3; SENP1; SENP3A; SENP3B; SENP5; SENP6
Function protein binding
Related Protein TRIM39; PTPN1; RAPGEF4; GFM1; LRP2; LSM2; TBX24; ZBTB44; GTF2E2; USP46
SENP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP6.
SP1; SCHIP1; glgB
SENP6 Related Articles
Gibbs-Seymour, I; Oka, Y; et al. Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage. MOLECULAR CELL 57:150-164(2015).
Tosti, E; Katakowski, JA; et al. Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells. GENOME MEDICINE 6:-(2014).