Recombinant Human SENP6 Protein (K628-D1112), GST tagged

• Cat.No.: SENP6-0894H
• Product Overview: Recombinant Human GST-TEV-GG-SENP6(K628-D1112 end) Protein was expressed in E. coli.

Specification

• Description: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: K628-D1112
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: SENP6 SUMO1/sentrin specific peptidase 6 [ Homo sapiens (human) ]
• Official Symbol: SENP6
• Synonyms: SENP6; SUMO1/sentrin specific peptidase 6; SUMO1/sentrin specific protease 6; sentrin-specific protease 6; KIAA0797; SUSP1; 2810017C20Rik; SUMO-1-specific protease 1; sentrin/SUMO-specific protease SENP6; SSP1; FLJ11355; FLJ11887; KIAA0389
• Gene ID: 26054
• mRNA Refseq: NM_001100409
• Protein Refseq: NP_001093879
• MIM: 605003
• UniProt ID: Q9GZR1