Recombinant Human SENP6 Protein, His-tagged SENP6-001H

Recombinant Human SENP6 Protein, His-tagged

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Recombinant Human SENP6 Protein, His-tagged

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Cat.No. : SENP6-001H
Product Overview : Recombinant human SENP6 (637-1112) protein with a N-terminal His-tag was expressed in E. coli.
Description : Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.
Source : E. coli
Species : Human
Tag : His
Protein length : 637-1112
Applications : Active Enzymes
Gene Name : SENP6 SUMO specific peptidase 6 [ Homo sapiens (human) ]
Official Symbol : SENP6
Synonyms : SENP6; SUMO specific peptidase 6; SSP1; SUSP1; sentrin-specific protease 6; 2810017C20Rik; SUMO-1-specific protease 1; SUMO1/sentrin specific peptidase 6; SUMO1/sentrin specific protease 6; sentrin/SUMO-specific protease SENP6
Gene ID : 26054
mRNA Refseq : NM_001100409
Protein Refseq : NP_001093879
MIM : 605003
UniProt ID : Q9GZR1

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