slc16a2
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  • Official Full Name
  • solute carrier family 16, member 2 (thyroid hormone transporter)
  • Background
  • This gene encodes an integral membrane protein transporter of thyroid hormone; specifically, cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues including brain, heart, placenta, lung, kidney, skeletal muscle, and liver. This gene likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation.
  • Synonyms
  • SLC16A2; solute carrier family 16, member 2 (thyroid hormone transporter); AHDS, Allan Herndon Dudley syndrome , DXS128, mental retardation, X linked 22 , MRX22, solute carrier family 16 (monocarboxylic acid transporters), member 2 , solute carrier fa
Cat.#:SLC16A2-15233MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC16A2 Protein
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Cat.#:SLC16A2-5440RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC16A2 Protein
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Cat.#:SLC16A2-8222ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC16A2
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Involved Pathway

SLC16A2 involved in several pathways and played different roles in them. We selected most pathways SLC16A2 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC16A2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway
MED27; KAT2B; MAPK1; ATP1A3; PLCE1; MTOR; MED1; ACTG1; THRA; MED12

Protein Function

SLC16A2 has several biochemical functions, for example, symporter activity, thyroid hormone transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC16A2 itself. We selected most functions SLC16A2 had, and list some proteins which have the same functions with SLC16A2. You can find most of the proteins on our site.
Function
Related Protein
Function symporter activity
Related Protein SLC1A8B; SLC34A2; SLC15A4; SLC5A4; SLC1A2A; SLC12A3; SLC24A1; PPP1R42; MFSD2AA; SLC6A4A
Function thyroid hormone transmembrane transporter activity
Related Protein SLCO4A1; SLC16A2; SLCO1C1; SLC16A10; SLCO1A5

SLC16A2 Related Articles

Capri, Y; Friesema, ECH; et al. Relevance of Different Cellular Models in Determining the Effects of Mutations on SLC16A2/MCT8 Thyroid Hormone Transporter Function and Genotype-Phenotype Correlation. HUMAN MUTATION 34:1018-1025(2013).
Merezhinskaya, N; Fishbein, WN; et al. Monocarboxylate transporters: Past, present, and future. HISTOLOGY AND HISTOPATHOLOGY 24:243-264(2009).
Moeller, LC; Dumitrescu, AM; et al. Thyroid hormone responsive genes in cultured human fibroblasts. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 90:936-943(2005).