Description : |
This gene encodes an integral membrane protein transporter of thyroid hormone; specifically, cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues including brain, heart, placenta, lung, kidney, skeletal muscle, and liver. This gene likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. |
Source : |
In Vitro Cell Free System |
Species : |
Human |
Form : |
Liquid, 25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
Molecular Mass : |
67.5 kDa |
Protein Length : |
1033 amino acids |
AA Sequence : |
MGRGGGGLDVGGGGEGSRDRLSRDG LASWGAEPGGGGSGSGSSSPPSSSS CSSRNKYQPQSGSSGPSSHSPPAAM ALQSQASEEAKGPWQEADQEQQEPV GSPEPESEPEPEPEPEPVPVPPPEP QPEPQPLPDPAPLPELEFESERVHE PEPTPTVETRGTARGFQPPEGGFGW VVVFAATWCNGSIFGIHNSVGILYS MLLEEEKEKNRQVEFQAAWVGALAM GMIFFCSPIVSIFTDRLGCRITATA GAAVAFIGLHTSSFTSSLSLRYFTY GILFGCGCSFAFQPSLVILGHYFQR RLGLANGVVSAGSSIFSMSFPFLIR MLGDKIKLAQTFQVLSTFMFVLMLL SLTYRPLLPSSQDTPSKRGVRTLHQ RFLAQLRKYFNMRVFRQRTYRIWAF GIAAAALGYFVPYVHLMKYVEEEFS EIKETWVLLVCIGATSGLGRLVSGH ISDSIPGLKKIYLQVLSFLLLGLMS MMIPLCRDFGGLIVVCLFLGLCDGF FITIMAPIAFELVGPMQASQAIGYL LGMMALPMIAGPPIAGLLRNCFGDY HVAFYFAGVPPIIGAVILFFVPLMH QRMFKKEQRDSSKDKMLAPDPDPNG ELLPGSPNPEEPI |
Notes : |
Best use within three months from the date of receipt of this protein. |
Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |