The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.
SSX4; synovial sarcoma, X breakpoint 4; protein SSX4; CT5.4; MGC12411; Synovial sarcoma X breakpoint 4; OTTHUMP00000024292; OTTHUMP00000216158; cancer/testis antigen 5.4; SSX4B
SSX4 has several biochemical functions, for example, nucleic acid binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSX4 itself. We selected most functions SSX4 had, and list some proteins which have the same functions with SSX4. You can find most of the proteins on our site.
Function nucleic acid binding
Related Protein PUF60A; ZCCHC2; ZEB2B; VEZF1B; ENPP1; RBM14B; RNASE7; TOE1; ZFP319; RAG1
Function transcription corepressor activity
Related Protein E2F7; HOMEZB; NRIP1; LMCD1; SSX1; FOXP3; ATN1; SAP18; HIPK2; ZHX3
SSX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSX4.