st8sia1
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  • Official Full Name
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Background
  • Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.
  • Synonyms
  • ST8SIA1; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; sialyltransferase 8 (alpha N acetylneuraminate: alpha 2,8 sialytransferase, GD3 synthase) A , SIAT8, SIAT8A; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia I; gangliosid
Cat.#:ST8SIA1-2982HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ST8SIA1, His-tagged
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Cat.#:ST8SIA1-30852THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ST8SIA1
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Cat.#:ST8SIA1-707HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ST8SIA1 Protein, His-tagged
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Cat.#:ST8SIA1-16078MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ST8SIA1 Protein
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Cat.#:ST8SIA1-6566CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ST8SIA1
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Cat.#:ST8SIA1-5197ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ST8SIA1
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Cat.#:ST8SIA1-1434HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ST8SIA1 293 Cell Lysate
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Involved Pathway

ST8SIA1 involved in several pathways and played different roles in them. We selected most pathways ST8SIA1 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST8SIA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosphingolipid biosynthesis - lacto and neolacto series
ST3GAL6; ST3GAL3B; FUT9A; B3GNT1; ST3GAL4; GGTA1; GCNT2; FUT4; B3GALT5; B3GNT3
Glycosphingolipid biosynthesis - globo series
ST8SIA1; B3GALT5; FUT9A; GBGT1L4; ST3GAL1; B3GALNT1; NAGA; GLA; FUT2; A4GALT
Glycosphingolipid biosynthesis - ganglio series
ST6GALNAC4; ST6GALNAC3; ST6GALNAC6; HEXB; ST8SIA5; GLB1; ST3GAL2; ST3GAL5; ST6GALNAC5; ST3GAL1
Metabolic pathways
AGPAT6; ACADM; HSD3B5; DAK; AKR1C3; ALOX5A; HMGCS2; EBP; PLA2G4A; LDHA

Protein Function

ST8SIA1 has several biochemical functions, for example, alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST8SIA1 itself. We selected most functions ST8SIA1 had, and list some proteins which have the same functions with ST8SIA1. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
Related Protein ST8SIA5; ST8SIA2; ST8SIA1; ST8SIA3
Function sialyltransferase activity
Related Protein ST6GALNAC3; ST3GAL5L; ST6GALNAC2; ST3GAL5; ST6GALNAC1.2; ST8SIA3; ST3GAL3A; ST6GALNAC5B; ST6GAL2A; ST6GAL2B

ST8SIA1 Related Articles

Miyata, M; Ichihara, M; et al. UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445:504-510(2014).
Bobowski, M; Vincent, A; et al. Estradiol Represses the G(D3) Synthase Gene ST8SIA1 Expression in Human Breast Cancer Cells by Preventing NF kappa B Binding to ST8SIA1 Promoter. PLOS ONE 8:-(2013).