stub1
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  • Official Full Name
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
  • Background
  • STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009]
  • Synonyms
  • STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; CHIP; UBOX1; HSPABP2; NY-CO-7; SDCCAG7; E3 ubiquitin-protein ligase CHIP; antigen NY-CO-7; CLL-associated antigen KW-8; serologically defined colon cancer antigen 7; STIP1 homology and U box-containing protein 1; carboxy terminus of Hsp70-interacting protein; heat shock protein A binding protein 2 (c-terminal);
Cat.#:STUB1-2989HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STUB1 Protein, MYC/DDK-tagged
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Cat.#:STUB1-336HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STIP1 Homology And U-box Containing Protein 1
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Cat.#:STUB1-265HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STUB1, His-tagged
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Cat.#:STUB1-30458THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STUB1
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Cat.#:STUB1-30459THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STUB1
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Cat.#:STUB1-16181MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STUB1 Protein
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Cat.#:STUB1-4539RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey STUB1 Protein, His-tagged
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Cat.#:STUB1-3057CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STUB1
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Cat.#:STUB1-10073ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STUB1
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Cat.#:STUB1-1715HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human STUB1 cell lysate
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Involved Pathway

STUB1 involved in several pathways and played different roles in them. We selected most pathways STUB1 participated on our site, such as Adaptive Immune System, Alpha-synuclein signaling, Androgen receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
CD200R2; BLMH; WSB1; KIF26A; RNF111; KIR2DS2; SPSB2; SIGLEC6; UBA5; PAG1
Alpha-synuclein signaling
FKBP1A; BLK; PARK7; STUB1; TOR1A; CSNK2A1; KLK6
Androgen receptor signaling pathway
PNRC1; SMARCE1; HTATIP; NR0B2A; NR2C2; NCOA2; EGFR; RNF4; RAD9A; KDM1A
Antigen processing: Ubiquitination &
LRRC41; VPRBP; RNF6; UBR1; ASB13; FBXO27; ASB8; UBE2J2; ASB4; RNF182
Proteasome degradation
IWS1; UFL1; ASB17; RNF41; FBXO44; ASB7; SPSB4; LRSAM1; RNF19B; MKRN1
Class I MHC mediated antigen processing &
FBXO3; CTSL2; VPRBP; HUWE1; ASB18; CTSL1; TRIM9; ASB6; RNF25; UBE2E3
presentation
ASB10; ERAP2; CYBB; MKRN1; CMTM2A; LRSAM1; TRIM11; TRIM9; FBXO17; SH3RF1
Downregulation of TGF-beta receptor signaling
USP15; UCHL5; STRAP; PMEPA1; SMAD3B; STUB1
Immune System
DDX41; GBP2; KPNA5; TXNIPA; SIGLEC7; SRMS; WASF3; GZMM; DEFB4B; AMICA1
Parkin-Ubiquitin Proteasomal System pathway
TUBA1B; HSPA7; STUB1; HSPA14; TUBB7P; TUBA3E; RNF19A; SIAH2; TUBA3D; UBE2J2

Protein Function

STUB1 has several biochemical functions, for example, G-protein coupled receptor binding, Hsp70 protein binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STUB1 itself. We selected most functions STUB1 had, and list some proteins which have the same functions with STUB1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor binding
Related Protein INSL3; UTS2D; GNA15; GNAT2; RSPO1; GNA13B; PSAPL1; S1PR2; STUB1; CORT
Function Hsp70 protein binding
Related Protein DNAJC10; RNF207; ERN1; TSACC; PACRG; TFRC; METTL21A; FAM119A; RPS3; PARK2
Function Hsp90 protein binding
Related Protein EIF2AK3; STUB1; PACRG; PPID; ERBB2; USP19; UNC45A; GBP1; CSNK2A1; CDC37
Function SMAD binding
Related Protein SKIB; TOB1; SOD3; SKIL; HMGA2; TGFBRAP1; PURB; EP300; ACVRL1; SNW1
Function TPR domain binding
Related Protein RAB8B; PDE2A; STUB1; HSP90AA1; HSP90AB1
Function enzyme binding
Related Protein HYAL2; SLC12A3; PPP3CB; PIAS1; ATG3; EHHADH; P4HB; EIF4E; CASP2; KMT2E
Function kinase binding
Related Protein FAS; GFAP; CHP1; C2orf44; CHP; SP100; ATF5; TNFAIP3; SNAI1; CEBPB
Function ligase activity
Related Protein RNF144AB; RNF123; RFWD2; RBBP6; PET112L; RING1; BRCA1; RNF144A; BARD1; MARCH3
Function misfolded protein binding
Related Protein HDAC6; BAG6; EDEM1; HSPA5; CLU; STUB1; SDF2L1; DNAJB9; DNAJC10; HSPD1
Function protein binding
Related Protein PTPN13; RPUSD3; PFKFB2; ZNF230; MPDZ; DHDDS; DCBLD2; ATRNL1; NAPB; RTP3
Function protein binding, bridging
Related Protein GATAD2A; VPS18; ST13; TNNT2A; TRIM17; TRIM22; NUFIP1; TRIM6; FBXW7; CSTA
Function protein homodimerization activity
Related Protein TGFB1; PITX2; GDNFA; NCR3; EIF2AK1; PFKM; OLIG2; UBE4A; IKBKG; P2RX7
Function ubiquitin protein ligase activity
Related Protein TRIM24; HERC6; ARIH1; LRSAM1; UBE2KA; TRIM32; CBL; HERC4; MSL2A; MED21
Function ubiquitin protein ligase activity involved in ERAD pathway
Related Protein PARK2; TMEM129; TRIM25; STUB1; RNF185; AMFR; SYVN1; RNF5
Function ubiquitin protein ligase binding
Related Protein POU5F1; RPA3; AXIN1; CCT2; ABI2; PTPN22; MAGEC2; TRAF6; CD40; AXIN2
Function ubiquitin-protein transferase activity
Related Protein TRIM56; G2E3; MARCH4; UBE2H; CDC23; PJA2; MKRN1; RNF181; RNF146; FBXO25
Function ubiquitin-ubiquitin ligase activity
Related Protein PPIL2; UBE4B; ANAPC11; PRPF19; STUB1; UBOX5; AMFR; UBE2K; RBX1

Interacting Protein

STUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STUB1.
HSP90AA1; HSPA8; HSPA1A; UBE2N

STUB1 Related Articles

Zhao, YX; Guo, H; et al. E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination. JOURNAL OF IMMUNOLOGY 194:1639-1645(2015).
Paul, I; Ghosh, MK; et al. A CHIPotle in physiology and disease. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 58:37-52(2015).