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  • Official Full Name
  • T, brachyury homolog (mouse)
  • Background
  • The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
  • Synonyms
  • T; T, brachyury homolog (mouse); TFT; SAVA; brachyury protein; protein T; T brachyury homolog;
Cat.#:T-130HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human T Protein, MYC/DDK-tagged
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Cat.#:T-27668THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human T
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Cat.#:T-27672THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human T
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Cat.#:T-16350MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse T Protein
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Cat.#:T-6500CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken T
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Cat.#:T-1294HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human T 293 Cell Lysate
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Involved Pathway

T involved in several pathways and played different roles in them. We selected most pathways T participated on our site, such as Cardiac Progenitor Differentiation, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with T were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cardiac Progenitor Differentiation
ZFP42; TBX20; SOX1; IRX4; TBX5; NKX2; ROR2; T; LIN28A; LIN28B
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
TLE1; CDX1; ZCCHC12; CBY1; AES; TNIK; TLE2; TCF4; CDX4; KCNIP4

Protein Function

T has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by T itself. We selected most functions T had, and list some proteins which have the same functions with T. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II activating transcription factor binding
Related Protein ATF2; HIPK2; T; EP300; CTNNB1; EOMES; LMO2; ISL1; NCOR1; SMAD3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein E2F4; CDX4; ZNF664; HNRNPK; NACC2; ETV1; ELF1; GATA4; NFIA; ZIC3
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein CREB1; BACH1A; NFATC1; FLI1; ARID3B; NR2F6; GATA2; GZF1; H2AFZ; ESRRB
Function RNA polymerase II transcription factor binding
Related Protein GATA1A; MIXL1; ZFPM2; GATA2; GATA4; SPI1; Ar; GATA3; ID4; GATA5
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein CREB1; ATF2; HNF1B; MYOD1; SRF; THRA; PDX1; NR5A2; GTF2IRD1; PAX3
Function transcription factor activity, sequence-specific DNA binding
Related Protein PHOX2A; NR6A1A; E2F2; PPARA; SMAD9; ALS2CR8; RUNX1; ZSCAN20; ZNF234; HOXB8
Function transcriptional repressor activity, RNA polymerase II transcription factor binding
Related Protein AHRRB; CREBBP; ELP2; AHRRA; AHRR; MINA; TBX6; RIMKLB; PITX2; BHLHE40

T Related Articles

Yang, YR; Feng, JD; et al. Immune Responses to a Recombinant Rv0057-Rv1352 Fusion Protein of Mycobacterium tuberculosis. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:39-48(2015).
Law, JKY; Susloparova, A; et al. Human T cells monitored by impedance spectrometry using field-effect transistor arrays: A novel tool for single-cell adhesion and migration studies. BIOSENSORS & BIOELECTRONICS 67:170-176(2015).

T Related Gene Family

IL