TCF3 Protein, transcription factor 3


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Official Full Name transcription factor 3
Background This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Synonyms TCF3; transcription factor 3; E2A; E47; ITF1; VDIR; TCF-3; bHLHb21; transcription factor E2-alpha; kappa-E2-binding factor; VDR interacting repressor; transcription factor ITF-1; helix-loop-helix protein HE47; transcription factor 3 variant 3; immunoglobulin transcription factor 1; vitamin D receptor-interacting repressor; class B basic helix-loop-helix protein 21; negative vitamin D response element-binding protein; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Pan2; Tcfe2a
    • Species :
    • Chicken
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TCF3-1180HCL Recombinant Human TCF3 293 Cell Lysate HEK293 N/A
    Human TCF3-29462TH Recombinant Human TCF3 Wheat Germ N/A
    Human TCF3-3158H Recombinant Human TCF3, GST-tagged E.coli GST
    Human TCF3-581H Recombinant Human TCF3 Protein, His-tagged E.coli His
    Rat TCF3-5989R Recombinant Rat TCF3 Protein Mammalian Cell His
    Chicken TCF3-6056C Recombinant Chicken TCF3 Mammalian Cell His

    TCF3 involved in several pathways and played different roles in them. We selected most pathways TCF3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, HTLV-I infection, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells FZD3; TCF3; WNT16; TBX3; AKT2; PIK3CA; INHBB; WNT9B; WNT11; BMP4
    HTLV-I infection HLA-E; FZD7; CCNB2; SFPI1; Pdgfa&Pdgfb; FOS; MAP3K1; TP53INP1; IKBKG; DVL1
    Transcriptional misregulation in cancer TP53; LDB1; ATF1; ELANE; HIST3H3; CD40; ATM; ELK4; FCGR1A; DDX5

    TCF3 has several biochemical functions, for example, DNA binding, contributes_to DNA binding, E-box binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF3 itself. We selected most functions TCF3 had, and list some proteins which have the same functions with TCF3. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding GTF3C4; GTF3C6; MLXIPL; FOXH1; MAFGA; GTF3C2; ARNTL1B; NFE2L2A; AHR2; TCF3
    E-box binding MYOD1; NEUROG1; TWIST1; GATA3; TCF4; TCF21; MYC; BHLHE40; ZEB1; TAL1
    contributes_to E-box binding MYF6; MYF5; TCF3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ATF4; CREB3; POU4F3; E2F8; MYBL2; CEBPZ; ZGPAT; NFATC4; SOX1; JUN
    bHLH transcription factor binding TWIST1; TCF21; HAND1; SIRT1; EP300; FOXH1; PSMD9; TCF3; SMAD3; TCF4
    chromatin binding CDCA5; GATA1A; PRKAA1; RELB; NCOA5; CENPA; Ar; HMGB3B; NUPR1; PBRM1
    enhancer binding SMAD2; ARNT; LEF1; TCF12; ELL3; FOXH1; SMAD3; SOX9; MESP1; AHR
    mitogen-activated protein kinase kinase kinase binding PPEF2; TCF3; MAPK8IP3; TRAF6; CDC42; MAP3K11; DUSP19; MAPK1; MAP2K1; TRAF2
    protein binding EDNRB; ACTR1B; FAM9C; COA3; PMAIP1; TNFRSF6B; NRG4; NXF2; ACAD9; DEAF1
    protein heterodimerization activity MYOD1; HIST1H4K; PVRL1; ZHX1; TLX1; ALG2; TCF12; KCNK3; HIST1H2A9; XBP1
    protein homodimerization activity RNF17; TRPM8; PDGFA; CARM1; TWIST1; ENO3; GABRR1; PKD2; SUPV3L1; CHMP3
    repressing transcription factor binding DDX20; RELA; ARNTL; SKI; CBX5; RUNX2; TCF3; CTNNB1; TLE4; PARK7
    contributes_to sequence-specific DNA binding HIF1A; ARNT; SMAD4; FIGLA; NEUROD1; PPARG; TCF3; HDAC4; TRIM28; EPAS1
    transcription coactivator activity KAT2B; ESR2; SMARCC2; NACA; DDX5; NR1H4; PIAS2; HIF3A; ABRA; UBE2L3
    transcription factor activity, sequence-specific DNA binding ATF6B; FOXP3; SALL3; FOXC1A; CLOCKA; NFIL3-4; SNAPC4; CNOT8; LHX1; GRHL2B
    transcription factor binding NR0B2; PPP1R13B; C1QBP; PPARGC1A; CEBPG; VDRA; RBPJ; FOXO4; TRIB2; MED6
    contributes_to transcription regulatory region DNA binding HDAC4; ATF4; TAF1; NFYA; HAND1; RXRA; NFYC; TCF12; HDAC5; TCF3
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NFIL3-2; NKX6; ASCL2; CC2D1A; PRDM1; SNAI2; ZNF148; ZFPM2A; TCF3; KCNIP3
    vitamin D response element binding TCF3

    TCF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF3.

    TAL1; ID3; TCAF1; ASCL1; dna-1; FOXH1; TCF12; Gata1; GATA2

    Soldini, D; Georgis, A; et al. The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas. HEMATOLOGICAL ONCOLOGY 32:120-125(2014).
    Lindskog, C; Kuhlwilm, M; et al. Analysis of Candidate Genes for Lineage-Specific Expression Changes in Humans and Primates. JOURNAL OF PROTEOME RESEARCH 13:3596-3606(2014).

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