| Description : |
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
67.4 kDa |
| AA Sequence : |
MNQPQRMAPVGTDKELSDLLDFSMM FPLPVTNGKGRPASLAGAQFGGSGL EDRPSSGSWGSGDQSSSSFDPSRTF SEGTHFTESHSSLSSSTFLGPGLGG KSGERGAYASFGRDAGVGGLTQAGF LSGELALNSPGPLSPSGMKGTSQYY PSYSGSSRRRAADGSLDTQPKKVRK VPPGLPSSVYPPSSGEDYGRDATAY PSAKTPSSTYPAPFYVADGSLHPSA ELWSPPGQAGFGPMLGGGSSPLPLP PGSGPVGSSGSSSTFGGLHQHERMG YQLHGAEVNGGLPSASSFSSAPGAT YGGVSSHTPPVSGADSLLGSRGTTA GSSGDALGKALASIYSPDHSSNNFS SSPSTPVGSPQGLAGTSQWPRAGAP GALSPSYDGGLHGLQSKIEDHLDEA IHVLRSHAVGTAGDMHTLLPGHGAL ASGFTSPMSLGGRHAGLVGGSHPED GLAGSTSLMHNHAALPSQPGTLPDL SRPPDSYSGLGRAGATAAASEIKRE EKEDEENTSAADHSEEEKKELKAPR ARTSPDEDEDDLLPPEQKAEREKER RVANNARERLRVRDINEAFKELGRM CQLHLNSEKPQTKLLILHQAVSVIL NLEQQVRERNLNPKAACLKRREEEK VSGVVGDPQMVLSAPHPGLSEAHNP AGHMTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
