Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HTLV-I infection FZD9,NRP1,NFKBIA,WNT11,MYBL2,VDAC1,ATF1,RRAS2,PIK3CG,HLA-F
    Epstein-Barr virus infection IL10RA,PLCG2,RELB,POLR3F,IKBKB,CD58,HLA-DPA1,PSMC6,POLR3E,HLA-DRA
    Bladder cancer ERBB2,EGF,TYMP,MMP9,KRAS,E2F2,HBEGF,DAPK1,MDM2,MMP1
    p signaling pathway PPM1DB,CASP9,SIAH1,PPM1DA,BBC3,TP53I3,SFN,BIDA,GADD45AA,BAX
    Hepatitis B PIK3CG,STAT5A,EP300,IKBKB,MMP9,BAX,TLR4,IFN-a,PRKCB,CREB3L2
    Thyroid hormone signaling pathway PLCD1,PIK3CD,HDAC2,PRKACA,NCOA1,ATP1B4,FXYD2,ITGB3,RCAN2,PLCB3
    Amyotrophic lateral sclerosis (ALS) NOS1,DERL1,MAPK12,MAPK11,BCL2L1,MAP2K6,GRIN1,RAC1,GRIA1,CASP9
    PIK-Akt signaling pathway ITGB7,MTCP1,GNGT2,LAMB2,ITGA10,LAMB4,RBL2,OSMR,HSP90AB1,FGFR4
    Huntingtons disease COX7C,ATP5G3,DCTN4,COX8A,NDUFA1,NDUFA11,COX6B1,POLR2A,NDUFA3,CREB3L2

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity ALX4,HER1,OSTA,PPP2R4,CEBPE,H3F3B,SDCBP2,SRY,BOK,UGT1A7
    RNA polymerase II core promoter sequence-specific DNA binding EGR1,SMAD5,TBR1,HNF4A,TAL1,TP53,RBPJ,SPI1,NR4A2,GBX2
    ubiquitin protein ligase binding UBE2J1,UCHL1,AKTIP,RRAGA,PDE4D,RPA3,GPR37,DLG3,TRAF3,NKD2
    protein C-terminus binding PIAS4,VGLL1,PHB,TCF4,OPRL1,ARL6IP5,SREBF2,C11orf60,BLOC1S2A,CTBP1
    histone deacetylase regulator activity MAPK8,TP53,NCOR1
    damaged DNA binding UNG,TP53BP1,RAD18,CREBBP,RAD1,RPA2,POLB,ERCC4,DCLRE1A,POLI
    p53 binding TAF9,TAF1,EHMT1,SETD8,ZNF385B,EP300,TP63,ZNF346,TRIM29,PTTG1IP
    double-stranded DNA binding TRP63,AIM2,MTERF2,FBXO18,SETMAR,HMGB3,HNRNPDL,XRCC3,SAFB,IFI203
    protein N-terminus binding ZWINT,PEX5,TGFB1,SCFD1,ACOX1,VPS25,KCNIP2,SYNGR3,RELA,NCOA1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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