Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection NFKBIB,TNFSF14,STAT1,UBE2R2,OAS1A,C3,MAPK9,FADD,SRSF6B,MAP3K7
    Bladder cancer E2F3,VEGFA,CDK4,UPK3A,MMP2,HBEGF,ARAF,CDKN2A,NRAS,TP53
    Glioma CALM3,SHC3,PIK3CG,MAP2K1,PLCG1,SOS1,PIK3R2,RAF1,CAMK2B,CALM1
    Transcriptional misregulation in cancer FCGR1,IL3,LYL1,ETV5,FOXO1,HIST1H3H,TFE3,SIX1,H3F3B,HIST1H3D
    Neurotrophin signaling pathway KIDINS220,SHC1,NFKB1,PIK3CG,RAP1B,MATK,RAP1A,GSK3B,BDNF,CAMK2D
    Chronic myeloid leukemia SMAD3,SMAD4,CBL,MECOM,CCND1,TGFB3,CTBP1,BRAF,SHC1,MAP2K2
    Proteoglycans in cancer DROSHA,AKT2,FZD7,MTOR,FLNC,GPC3,PTPN11,Fzd4,CTTN,WNT1
    Prostate Cancer AKT2,IGF1,MAP2K1,MAP4K1,NKX3-1,BAD,HRAS,BRAF,ARID1A,IKBKG
    Hepatitis C PIAS1,IFNA5,RIPK1,MAPK1,IRF1,Ifna11,CLDN8,TNFRSF1A,MAPK12,TLR3

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding TBX5,ETV3,OSR2,GATA1,ZBTB11,RXRB,ARID5B,ETV6,H2AFY2,FERD3L
    DNA binding YY1,SP8B,GTF2A1,ZNF280B,SSBP3B,EBF2,PDS5B,ETV5B,ZNF566,ZNF554
    chaperone binding CP,ATP1A3,DNAJB5,TP53,HSCB,PIH1D3,PFDN4,DNAJA3A,HLA-B,Alb
    metal ion binding CYP2C55,ZNFL1,FAM170A,PPP3CB,CCC2,NEK10,LHX8,CYP3C1L2,CBFA2T3,THOP1
    enzyme binding SIRT3,BACE1,NPC2,MTA1,TRIO,CREB1,TSPAN17,DDX5,APOA5,BCL10
    p53 binding ZNF385C,BANP,PSME3,HSPD1,TP53RK,EHMT1,BRD7,BRD4,EP300,DAXX
    transcription factor activity, sequence-specific DNA binding TAL1,TEFA,ELK3,ZSCAN4F,ZSCAN12,BACH2,ZFP322A,ZNF189,MYCLA,POU3F3A
    histone deacetylase regulator activity MAPK8,NCOR1,TP53
    protein self-association EPB49,CBR2,ABCD3,CTSB,AGTR1A,CTSC,TRIM32,AGXT,MALT1,TMEM43

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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