Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HTLV-I infection CCND2,HLA-F,POLD4,EGR1,GM-CSF,WNT2B,CD3E; CD3D,NFKB2,HRAS,PIK3R5
    Measles IFNA2,IFNA12,CCNE1,IL1B,IL2RA,Ifna11,STAT5A,TLR2,TNFRSF10C,IRAK1
    Glioma HRAS,CALM1,MAPK1,IGF1R,BRAF,SHC3,NRAS,KRAS,ARAF,MAP2K1
    Bladder cancer IL-8,E2F3,HRAS,ERBB2,MMP9,MAPK3,MYC,ARAF,MAPK1,BRAF
    p signaling pathway PTENB,CCNB1,SESN2,TSC2,CYCSB,CCNB3,CASP3B,BIDA,ZMAT3,PTEN
    Prostate Cancer PTEN,PDGFD,PDPK1,GSK3B,PIK3CB,NDRG1,CCND1,HSP90AB1,PDGFB,CCNE1
    Epstein-Barr virus infection NFKBIE,PIK3CA,TRADD,PIK3CD,MAPK13,TRAF3,PSMC3,PSMD11,H2-Q10,RELB
    Amyotrophic lateral sclerosis (ALS) TP53,TOMM40,TNFRSF1B,BID,CCS,TNFRSF1A,SOD1,DAXX,GRIN2D,PPP3CC
    Herpes simplex infection SOCS3B,SRPK1,HLA-DPA1,PPP1CAA,BMA1,LOC100033925,UBE2R2,CCL5,PILRA,TAF10

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor binding KLF4,HCLS1,PITX2,SPI1,GATA2A,ZFPM1,ZGLP1,GSK3B,CREBBP,MKX
    core promoter sequence-specific DNA binding GATA3,PDX1,SOHLH1,MTA1,MLL1,NRF1,PPARG,ZFHX3,KLF10,NR4A3
    protein heterodimerization activity SCGB2A1,PPARD,H2AFB3,Bcl2a1b,UBA2,TAF9B,GCA,TFDP3,SOS1,HIST2H2AA4
    protein C-terminus binding SIRT1,MKI67,ITGB3BP,SNF8,CDC37,VPS4B,PPM1A,KPNA3,ZBTB16,TNNI3K
    identical protein binding APOE,RABAC1,MSANTD3,PFKL,DYNLT1C,TRIP10,MMP9,USP2,AGXT2L2,APLP1
    p53 binding TP63,ZFP385C,BLM,MSX1,GSK3B,GATA1,TRP63,TAF1,EHMT1,RFWD3
    damaged DNA binding ERCC4,RAD23A,FANCG,HMGB2,XRCC5,RAD23B,XPA,TRPC2,DCLRE1C,CRY-DASH
    MDM2/MDM4 family protein binding PSME3,PPARA,CDK5RAP3,RFWD3,CDKN2A,CAV1
    RNA polymerase II transcription factor activity, sequence-specific DNA binding SOX5,SP3A,HOXA13A,POU5F1,MITFB,ATF4B1,SPDEF,ELK4,CC2D1A,NPAS1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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