Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway MED12L,SLC9A1,MDM2,MAP2K1,NCOA1,TBC1D4,NRAS,TP53,SLC16A2,BAD
    Thyroid cancer NCOA4,PPARG,MAP2K2,TPM3,RXRG,CCDC6,RXRA,TP53,HRAS,KRAS
    PIK-Akt signaling pathway IFNA5,IKBKB,PIK3CA,MAP2K1,PCK1,EIF4E1B,PRLR,LPAR5,Kitl,LAMA5
    Prostate Cancer SMARCC2,PIK3R2,MAP2K2,HSP90AA1,CREB3L2,SRD5A2,RAF1,PIK3CB,PDGFD,PDPK1
    Transcriptional misregulation in cancer KDM6A,NUPR1,CCNT2,JMJD1C,SP1,PBX1,PROM1,RXRB,MLLT1,DDX5
    Bladder cancer DAPK1,IL-8,DAPK2,MAPK3,E2F3,EGF,RASSF1,KRAS,MYC,CDH1
    Wnt signaling pathway DKK4,RHOA,TBL1X,MAPK9,NLK1,PRKCBB,LRP5,AXIN2,GSK3AA,CCND3
    Glioma CAMK2G,CALM4,PDGFRB,PLCG2,SHC3,MTOR,PDGFB,PRKCB,CALM2,PIK3CG
    Small cell lung cancer AKT1,PIK3R1,LAMC1,LAMA1,PTEN,BIRC3,CASP9,APAF1,NOS2,TRAF3

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein phosphatase binding MAPK14,TRAF3,TP53,VCP,JAK3,STAT6,KAT2A,CSK,ANAPC7,ANAPC5
    ubiquitin protein ligase binding UBE2C,MID1,ANKRD32,CASP10,H2-AB1,MAP1LC3B,RRAGA,CUL4B,BAG4,USP2
    transcription factor activity, sequence-specific DNA binding ZIC1,CREB1B,PGBD1,PPARAA,HSFY1,ZNF187,VDRB,CTBP1,SPZ1,RARA
    protein phosphatase 2A binding PPME1,SMG5,IGBP1,BCL2,TP53,RPS6KB1,MAPT,PPP2R4,ANKLE2,ENSA
    protein C-terminus binding TAX1BP3,PCGF1,CACNA1B,PHB,PLEKHB1,AGO2,PXK,PEX5,ERCC2,MID1IP1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MAFK,TP53,ATF3,GATA6,PPARG,BARHL1B,SLAMF7,BHLHA15,NKX2,GATA2
    protein kinase binding SPDYB,PLK1,SLC12A7,NGFRAP1,H2AFY,CD8A,USF1,TPRKB,LAX1,NCS1
    histone acetyltransferase binding NR4A3,CEBPB,EGR1,EID1,MYOCD,TAF7L,CREB1,HIF1A,TRIM68,GLI3
    RNA polymerase II core promoter sequence-specific DNA binding HOXB3,FOS,SOX11,HEYL,MITF,RREB1,PAX8,ZNF335,MAZ,GATA1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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