Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway MAP2K1,SGMS1,ACER1,FCER1A,SPHK2,PPP2R5A,RHOA,PLCB3,MAPK1,BCL2
    Apoptosis DIABLOA,HIST1H1E,DCC,YWHAQ,PIK3R3,MYC,OCLN,BID,Fasl,BIRC5A
    MicroRNAs in cancer CDC25C,ITGA5,CDC25A,CDCA5,SOX4,PDGFRB,PLAU,ABCB1A,DDIT4,NRAS
    Cell cycle RBBP7,SMC1B,DNA2,E2F3,KIF2B,ENSAB,CDK11A,TGFB1A,MYCA,ORC6
    HTLV-I infection WNT11,SPI1,PPP3CC,PIK3R2,APC,PDGFA,ANAPC2,HLA-DRB5,SLC2A1,IL6
    Herpes simplex infection NXF3,Ifna15,TNFSF14,CD74,TYK2,IFNB,UBE2R2,MAPK8B,DDX58,RELA
    Thyroid hormone signaling pathway MAP2K2,MED14,KAT2A,RXRG,HDAC1,NRAS,PLCB2,MDM2,MED4,KAT2B
    Small cell lung cancer PIK3R5,TRAF2,CCNE1,PTGS2,IKBKG,ITGB1,ITGA2,TRAF1,CCND1,LAMA4
    Central carbon metabolism in cancer PFKP,PIK3R2,PIK3R1,GLS,NRAS,G6PDX,PIK3R5,KRAS,MAPK3,NTRK1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein C-terminus binding BCL10,HSPB7,PPP2CB,PRDX3,PXK,DGKZ,HPCAL4,PPM1A,NIPBL,TCF4
    chaperone binding RNF207,BAG5,DNAJA1,DNAJB1,HLA-B,TBCD,DNAJB5,DNAJB8,STIP1,HSPD1
    transcription factor activity, sequence-specific DNA binding ZNF445,HMG20A,NR1I3,TCF3,ZSCAN10,ZNF518A,SOX1,NR2F1A,SMAD7,ZFP11
    histone acetyltransferase binding HIF1A,GLI3,EGR1,ETS1,TAF7,ZBTB7A,KAT2B,CEBPB,TRIP4,TRIM68
    DNA binding MSXE,FOXB1B,PUF60B,ZNF572,LCOR,TAF4B,TBX1,EMX3,HOXD4A,HLTF
    ATP binding MAP2K4,ITPK1,PEX6,MSH3,MYHC4,MAPK14A,ABCB3L1,PKN3,TEC,CHD2
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding SOHLH2,NEUROD2,ETV5,ALX1,GATA6,BARHL1B,GATA2B,AIRE,GATA4,MAFBB
    protein heterodimerization activity CUL3,POLE3,SNX1,DDX1,TAF6L,ADORA1,CEBPB,ITGB1A,Pdgfa&Pdgfb,BAD
    protein kinase binding PARK2,CALM2,DCX,STX1B,HIF1A,PRC1,CD3E,Fert2,GHR,USP37

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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