Trp53 Protein, transformation related protein 53

Trp53

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Trp53

Official Full Name transformation related protein 53
Synonyms bbl; bfy; bhy; p44; p53; Tp53
    • Species :
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse TRP53-17432M Recombinant Mouse TRP53 Protein Mammalian Cell His
    Mouse Trp53-5632M Recombinant Mouse Trp53 protein, His-tagged E.coli His
    Kit-0642 p53 Translocation Assay Kit (Cell-Based) N/A
    Kit-2107 p53 Transcription Factor Activity Assay Kit N/A

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNA2D3; FGF20; NR4A1; FLNB; PRKACG; CDC42L; NLK1; MAP2K2B; TRAF6; MKNK2A
    Sphingolipid signaling pathway S1PR4; PPP2R3C; NOS3; MAPK10; PDPK1; PIK3CB; PRKCZ; FCER1G; AKT1; FCER1A
    Cell cycle HJURP; CEP63; EP300; MIS18BP1; MPEG1.1; STAG1; TUBGCP3; TGFB1A; NPM1; MLF1IP
    p signaling pathway TRP53; BIDA; RPRM; CD82A; CASP3A; CD82B; RPRMA; CASP8; CASP9; CCNB2
    PIK-Akt signaling pathway RPS6KB1; OSMR; PIK3CG; Pdgfa&Pdgfb; VEGFA; GRB2; PDGFD; IL2RA; PPP2R5D; YWHAG
    Apoptosis CAPN1; CAPN1A; IRAK3; TRAF2; TNFRSF10C; PLECA; PRKAR2AA; BID; IRF4; PPP3R1B
    Wnt signaling pathway FOSL1A; WNT4A; FBXW11B; WNT2BA; MAPK9; FZD2; NLK1; BAMBI; VANGL2; PRKCG
    Neurotrophin signaling pathway SH2B2; GAB1; RPS6KA3; TRP53; MAPK9; CAMK2G; SHC2; SHC4; MAP2K5; PDPK1
    Thyroid hormone signaling pathway PFKP; NCOA1; PIK3R5; PIK3CA; ATP1B1; ATP2A2; NOTCH1; ATP1B4; FOXO1; WNT4
    Amyotrophic lateral sclerosis (ALS) GRIN2B; MAP3K5; NEFH; GRIA2; MAPK12; DAXX; PPP3R1; Casp3; BAX; CASP9
    Huntingtons disease Atp5g2; COX8C; SDHD; CREB3L2; UQCRQ; CYCS; CREB3L1; TGM2; ITPR1; ATP5E
    Hepatitis C OCLN; IFNA10; IFNA5; CLDN8; MAPK11; PPP2CA; TRAF2; SCARB1; Ifna11; PIAS1
    Hepatitis B RELA; MAP2K4; IFNA14; CASP10; CASP9; PIK3CG; IFN-a; IFNAR1; TGFB2; NFATC4
    Measles IL6; HSPA2; IL1B; cgr2b; IFNB1; DDX58; IFNA8; BBC3; IFNGR1; TRAF6
    HTLV-I infection CRTC3; CALR; TRP53INP1; IKBKG; MYBL2; CDC16; SPI1; LTBR; MYB; HLA-DRB4
    Herpes simplex infection TAF6L; SRSF7; IFNA13; HLA-F; MAPK10; IKBKG; IL12A; ARNTL1A; CCL2; TAF6
    Epstein-Barr virus infection HDAC2; POLR1C; SKP2; MDM2; PIK3R2; TBPL1; TBP; RIPK1; POLR3B; YWHAE
    Pathways in cancer HSP90AA1; PRKACA; EGLN1; FLT3LG; VEGFB; RET; SLC2A1; MMP9; GNG3; Kitl
    Transcriptional misregulation in cancer BCL2L1; MLLT3; SS18; IL3; HIST1H3H; SP1; IGF1; TSPAN7; ELK4; PRCC
    Viral carcinogenesis ACTN2; SYK; HDAC8; TRAF1; HIST1H4I; POLB; HDAC2; DLG1; GTF2E2; CCND1
    Proteoglycans in cancer SRC; PIK3R2; KRAS; CAMK2D; PTPN6; WNT7B; MAPK11; PTK2; ARHGEF12; ITPR1
    MicroRNAs in cancer STAT3; CCND2; PRKCB; FSCN1; DNMT3A; ABCB1A; TNR; SOS1; WNT3; SIRT1
    Colorectal cancer BCL2; TGFB3; TGFBR2; PIK3R2; AXIN1; TGFBR1; SMAD4; RAC3; RAF1; TRP53
    Pancreatic cancer PIK3R2; MAPK10; PIK3CG; TP53; RAC3; ARAF; PLD1; ARHGEF6; PIK3R5; VEGFA
    Endometrial cancer ARAF; SOS1; PIK3CA; ILK; BRAF; TRP53; PIK3R5; FOXO3; TCF7L2; CASP9
    Glioma PDGFA; PRKCG; PLCG1; HRAS; AKT1; KRAS; CAMK2A; PIK3R5; PDGFB; PIK3CD
    Prostate cancer PIK3CB; MDM2; AKT2; RELA; ATF4; HSP90B1; PDGFB; PIK3CD; GSK3B; PTEN
    Thyroid cancer CCND1; MAPK1; TPM3; TCF7; TP53; NCOA4; TFG; RXRA; NTRK1; BRAF
    Basal cell carcinoma WNT3A; AXIN2; DVL1; HHIP; GLI1; FZD3; TCF7L2; WNT9B; STK36; WNT3
    Melanoma RB1; PDGFD; AKT2; PIK3R3; PIK3CG; FGF10; FGF8; BAD; AKT1; FGF11
    Bladder cancer E2F3; CDH1; EGF; MAPK1; MMP1A; FGFR3; HBEGF; MMP9; MAPK3; THBS1
    Chronic myeloid leukemia CRK; PIK3CD; AKT1; PIK3R2; NFKB1; GRB2; MAP2K1; CTBP1; BCR; IKBKG
    Small cell lung cancer ITGA2B; PIK3R1; NFKBIA; TRAF2; PIK3CG; PTEN; RELA; AKT2; CCNE1; BIRC3
    Non-small cell lung cancer MAPK1; PIK3R2; GRB2; AKT2; PLCG1; RB1; PIK3R3; RXRB; MAP2K1; PRKCG
    Central carbon metabolism in cancer HK1; HKDC1; C12orf5; SLC16A3; PFKP; SLC2A2; FGFR3; NRAS; TP53; PKM2

    Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding STK32B; LATS2; UCK2A; ABCC2; MYO7AA; PAK1; ABCA9; GARS; KIF3A; UBE2KA
    DNA binding VDRB; HMGA1; EXO5; NFRKB; ZNF653; RFXAP; ZNF80; NFE2L2A; ZBTB17; TRIM28
    MDM2/MDM4 family protein binding RFWD3; PSME3; PPARA; TRP53; CAV1; CDKN2A; CDK5RAP3
    RNA polymerase II core promoter sequence-specific DNA binding STAT5A; EGR1; MAZ; IRF7; TCF7L2; RUNX2; TFAP2A; SUZ12; SOX8; GBX2
    RNA polymerase II regulatory region sequence-specific DNA binding PHOX2A; ACTN4; ZFAT; POU3F4; GATA1A; ATF4B2; CUX2; PURB; RXRA; ELF5
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXA2; FOXD2; ZSCAN1; ERF; FOXS1; ETV5B; FOXO3; FOXG1B; ZNF496; FOXA
    RNA polymerase II transcription factor binding MEF2A; GATA3; TBX6; GATA6; NFATC1; ZFPM2; WWP2; MKX; GFI1B; MIXL1
    chaperone binding SERPINA7; PFDN6; DNAJB8; TG; TSACC; DNAJA3A; DNAJB5; DNAJB1; BAG4; BAK1
    chromatin binding ACTL6A; PBRM1L; GATA4; SOX9; PARP1; TBL1Y; RAN; TFAM; SIN3B; NEUROD1
    copper ion binding PARK7; MOXD2; LOXL5B; MOXD1; S100A5; SNAI3; ATP7A; LOXL1; S100A12; POLR1B
    core promoter sequence-specific DNA binding ZNF750; REST; SOX4; NFYA; C1orf51; SOHLH1; MYOCD; SIRT1; KLF10; THRAP3
    damaged DNA binding TP73; RBBP8; FEN1; ERCC4; MPG; EP300; TDG; RAD23A; TRPC2; RAD52
    double-stranded DNA binding HLF; MTERFD1; KIN; HMGB3; MRE11A; IFI203; FEN1; MCM10; TDG; RAD51L1
    enzyme binding UGT1A3; SCARB2; SNX12; H2AFX; SIRT3; SORT1; CASC3; KAT8; HSPA2; NLRP1
    histone acetyltransferase binding KAT2B; PCNA; HIF1A; TAF7L; FOXP3; CITED2; MYOCD; TAF7; SIRT2; TRP53
    histone deacetylase regulator activity MAPK8; TP53; NCOR1; TRP53
    identical protein binding CLDN2; SCUBE1; ASS1; RILPL2; CST3; ITGB3; CLDN6; SEPHS1; UHRF1; CLDN10
    metal ion binding HECTD1; EGR2B; CYP39A1; TENC1; ZBTB44; TATDN1; Car9; ATP1A1A.1; STK32A; MT1X
    p53 binding EHMT2; ZNF385A; TRIM24; MDM2; EP300; TP53BP1; ANKRD1; HTT; RNF20; SMARCB1
    protease binding PYCARD; OS9; HSPD1; SERPINA1A; INS; SEMG2; FLOT1; IL1R1; DVL3; BCL2
    protein C-terminus binding PEX16; CEP135; PEX12; MYO1C; PHB; PABPC1; HIC2; KSR1; VTA1; SIAH1
    protein N-terminus binding TGFB1; NCOA3; SDCBP; TRAF6; NCOR2; CHMP6; EXOC5; RELA; PPP1CC; SNCA
    protein binding PPP1R7; FNIP1; HSPB6; WBP1L; RHBDD1; LRRFIP2; LRRK1; ADAMTS10; CCDC112; LDB1
    protein heterodimerization activity UGT1A6B; EPAS1; SNX1; HIST1H4L; HIST1H4A; FLOT2; Pdgfa&Pdgfb; EFHA1; SLC51A; SLC51B
    protein kinase binding TRIB3; Cd24a; GSK3B; CDK5; GCSAM; TSKS; ADIPOR1; CEP152; CD226; SOCS1
    protein phosphatase 2A binding MAPT; SHC1; STRN4; CTTNBP2NL; PPP2R2A; FOXO1; MASTL; CPD; STRN; BCL2
    protein phosphatase binding DRD1; IRS2; VRK3; TP53; SHOC2; KCNN4; TRAF2; TRAF3; CSK; ITPR1
    protein self-association TP53; CTSC; NKX3; ZNF496; ACVR2A; TRP53; SVIP; PCSK9; CTSB; TMEM43
    receptor tyrosine kinase binding ZNF259; MYOC; CPNE3; ANGPT1; FNTA; ELMO2; NRG1; ANXA5; SHC3; FLT3LG
    sequence-specific DNA binding TBX5A; TEFB; PAX6B; HOXB6A; POU3F3A; MEOX2; LMX1A; SIX4A; ZNF187; LHX1A
    transcription cofactor binding TRP53; KLF4; CHD6; FOXO3
    transcription factor activity, sequence-specific DNA binding ZNF263; HOXD10; SCML2; HOXB4; ATF5; ATF7; HOXB2A; ZFP260; ZIK1; NR2F1B
    transcription factor binding CCND1; CEBPA; NCOA2; TBL1X; CDKN2A; HMGA1-RS1; SUMO1; PPP1R13B; VDRA; GTF2B
    transcription regulatory region DNA binding SMAD6; SNCA; XBP1; OVOL2; LEF1; MTERFD3; ATF5; BRCA1; BASP1; ARID5B
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding POU4F3; FOSL1; NKX2-8; FOXI1; POU1F1; JUN; RUNX2; PPARA; NFYC; PATZ1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GRHL2; MAFG; CSRNP2; NR1I2; OVOL2; GATA4; SOX17; BARX1; SOHLH1; RAD21
    ubiquitin protein ligase binding UBE2H; PER1; TXNIP; MDM2; NLK; ERLIN2; GABARAPL2; AXIN1; CUL4A; CHEK2

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40; atp; Mdm2

    Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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