Trp53 Protein, transformation related protein 53


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Official Full Name transformation related protein 53
Synonyms bbl; bfy; bhy; p44; p53; Tp53
    • Species :
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse TRP53-17432M Recombinant Mouse TRP53 Protein Mammalian Cell His
    Mouse Trp53-5632M Recombinant Mouse Trp53 protein, His-tagged E.coli His
    Kit-0642 p53 Translocation Assay Kit (Cell-Based) N/A
    Kit-2107 p53 Transcription Factor Activity Assay Kit N/A

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway PLD2; SMPD2; S1PR5; FCER1A; PPP2R1B; PPP2R5E; PIK3CG; MAPK10; OPRD1; PDPK1
    Cell cycle CDT1; CDK4; GORASP2; FOXM1; PCNA; BABAM1; SYCP2; CDC45; DPF1; BLZF1
    p signaling pathway PTENA; PTENB; GADD45AA; BBC3; CASP3B; PPM1DB; SHISA5; APAF1; CCND3; CDK1
    PIK-Akt signaling pathway EPO; PIK3CG; IL2RG; FGF9; RBL2; GNG8; CREB5; INS2; YWHAG; FGF5
    Wnt signaling pathway FZD3B; WNT8B; PLCB1; PRKCG; DKK2; SOX17; PRKCA; CXXC4; PRICKLE2B; FBXW11A
    Neurotrophin signaling pathway ATF4; MAPK1; MAP2K1; RAF1; Fasl; FOXO3; NGF; ABL1; SHC3; PSEN2
    Thyroid hormone signaling pathway NCOA3; TRP53; FXYD2; CASP9; RAF1; PLN; RCAN2; PRKACB; PFKFB2; ATP1B2
    Amyotrophic lateral sclerosis (ALS) CAT; ALS2; GRIN1; MAPK11; PPP3R1; TRP53; TNFRSF1A; TP53; DAXX; BID
    Huntingtons disease CREB3L3; GRM5; PLCB1; UQCRB; POLR2K; DNAI2; HDAC1; PLCB2; DNAL1; VDAC3
    Hepatitis C IFNAR2; IRF7; PDPK1; CLDN22; MAPK1; PIAS1; CLDN14; CLDN17; IRF9; GRB2
    Hepatitis B PIK3CB; BCL2; ELK1; SRC; PRKCA; Casp3; EGR2; IFNA1; TICAM2; IFNA7
    HTLV-I infection POLD1; GPS2; XBP1; BAX; ITGB2L; HLA-DRA; Fzd4; TLN1; WNT3A; HLA-DRB1
    Herpes simplex infection CUL1A; FAS; CDC34A; NFKBIB; STAT1; CSNK2A2; HLA-DRA; SKP2; TBPL1; TLR2-1
    Epstein-Barr virus infection TAB1; TRAF2; NUP214; POLR2A; PSMD4; PIK3CA; GTF2E2; SKP2; PLCG1; POLR2C
    Pathways in cancer PLCB2; FOS; BMP2; FGF4; TGFA; ARNT2; RAD51; RASSF1; NFKB2; SOS1
    Transcriptional misregulation in cancer ATF1; EWSR1; LMO2; ELANE; KDM6A; CLSTN2; HDAC2; PROM1; Itgam&Itgb2; NFKBIZ
    Viral carcinogenesis HIST1H4L; HDAC4; GSN; TBP; STAT3; HPN; PIK3CB; RBL2; CCND2; VDAC3
    Proteoglycans in cancer CD44; IL12B; ROCK1; CAMK2D; SDC2; FZD1; SMO; Ctsl; RPS6KB1; COL21A1
    MicroRNAs in cancer IRS2; NOTCH1; NOTCH3; WNT3A; ZEB1; IKBKB; ERBB3; TIMP3; SOX4; PTGS2
    Colorectal cancer TGFB2; TGFBR1; MSH6; BIRC5; ARAF; SMAD2; RHOA; MAPK8; MLH1; SMAD3
    Pancreatic cancer PIK3CB; BRCA2; TRP53; TGFB3; TP53; SMAD3; PLD1; RAC3; ARAF; RB1
    Endometrial cancer AKT1; KRAS; RAF1; BAD; SOS1; CTNNA2; PDPK1; APC; MLH1; PIK3CD
    Glioma Pdgfa&Pdgfb; SOS1; ARAF; SHC4; TP53; PIK3CB; PDGFRB; PIK3CG; AKT1; KRAS
    Prostate cancer PDGFB; NFKB1; TCF7; IGF1; NDRG1; TCF7L2; FGFR1; MDM2; IGF1R; PDGFRB
    Thyroid cancer RXRA; HRAS; TFG; KRAS; NTRK1; TCF7; TPM3; NCOA4; CCND1; PAX8
    Basal cell carcinoma FZD1; PTCH1; WNT10B; WNT5A; TP53; LEF1; APC; DVL2; FZD3; TCF7L2
    Melanoma PDGFA; FGF16; MAP2K1; HGF; FGF5; Fgf15; Pdgfa&Pdgfb; FGF21; MDM2; PIK3R1
    Bladder cancer MMP2; THBS1; FGFR3; KRAS; SRC; IL-8; NRAS; CDK4; UPK3A; HBEGF
    Chronic myeloid leukemia PTPN11; GAB2; AKT1; PIK3R1; MECOM; BCL2L1; SOS1; PIK3CD; STAT5B; MAPK1
    Small cell lung cancer COL4A1; LAMA1; ITGAV; TRAF2; PTGS2; FHIT; LAMB4; LAMA2; ITGA2B; PTEN
    Non-small cell lung cancer PIK3CD; RB1; FHIT; TGFA; PRKCG; PRKCB; MAP2K1; PLCG2; STK4; PDPK1
    Central carbon metabolism in cancer LDHA; PIK3R3; PDGFRA; HRAS; MAP2K2; PKM2; MAPK1; FGFR3; G6PDX; PDHA2

    Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZNF286A; CCDC79; POLR2I; HNF1BB; KDM5D; OLIG2; FOXF2A; NR5A1; PAX1; ATOH8
    MDM2/MDM4 family protein binding CDKN2A; TRP53; PSME3; CDK5RAP3; CAV1; PPARA; RFWD3
    RNA polymerase II core promoter sequence-specific DNA binding RREB1; SUZ12; RUNX2; HEYL; SMAD5; H3F3B; SMYD3; PAX6; TRP53; RUVBL2
    RNA polymerase II regulatory region sequence-specific DNA binding GLIS1; AIRE; POU3F4; MEF2A; TFAP2C; TFAP2E; BHLHA15; NHLH2; ZFY2; BCL6
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXK1; POU5F1; ELF3; HIF1AB; SP4; PEG3; SIM1; FOXE1; SOX30; FOXO3A
    RNA polymerase II transcription factor binding ANKRD1; GATA1A; NFATC1; GATA2B; DHX9; GATA2; GATA5; Ar; SMAD4; XBP1
    chaperone binding USP13; DNAJA3A; AMFR; DNAJB5; BAX; HYOU1; TBCD; ATP1A1; DNAJA2L; TBCC
    chromatin binding NKAP; NPM2; SETD7; BRD2; KDM5A; NUPR1; TRIM37; UXT; HMGB2B; PHF21B
    copper ion binding DCT; ATP7A; ABHD1; AOC3; IL1A; COX17; ATOX1; ABP1; S100A13; PARK7
    core promoter sequence-specific DNA binding SOX4; ATF4; REST; ZFP750; NFYA; PRMT5; MYOCD; PDX1; SIRT1; ZFHX3
    damaged DNA binding RAD18; RAD23AA; NEIL2; APEX1; RPA2; CREBBP; FANCG; ERCC3; TRP53; MGMT
    double-stranded DNA binding GATA1A; XRCC6; HLF; SATB1; RAD51; HMGB2; NEIL3; TP63; AFF3; MTERFD2
    enzyme binding UGT1A6A; TSPAN17; HMOX1; HOXA9; TGFB1; AXIN1; Il6ra; MAPK8; APOA1; NOP14
    histone acetyltransferase binding MTF1; PCNA; MEF2A; SP1; ETS1; FOXP3; KAT2B; NR4A3; CREB1; EID1
    histone deacetylase regulator activity TP53; NCOR1; MAPK8; TRP53
    identical protein binding VCP; ST13; GBP5; KHDC1A; TRA@; DYNLT1B; HOOK1; SMURF2; C1QTNF6; LECT2
    metal ion binding ACAP3; GTSF1L; ASAP2B; ZNF19; BMPR1BB; ZNF766; ZNF608; FURIN; TAF1B; LMX1BB
    p53 binding CREBBP; TP73; SMARCB1; EP300; AAAS; SETD7; TRP63; DUSP26; TP63; TAF1
    protease binding SERPINA1E; BRCA2; DVL3; SERPINA1D; BCL10; A2M; HSPA6; SERPINB6; ANXA2; SERPINA1
    protein C-terminus binding DYNLL1; EP300; CTBP1; PEX26; SCLT1; VPS36; HSPB7; RBFOX1; VGLL2; SNX17
    protein N-terminus binding ID1; NCOR2; MNAT1; RPS21; CSNK2A2; ERCC3; CSNK2A1; YWHAQ; TRP53; DCN
    protein binding CSF2; ETS2; PSMB3; GAGE8; SEMA4D; NUDT2; ING5; NR1H2; GIMAP5; HBZ
    protein heterodimerization activity SMAD3; SOS1; P4HB; MAP3K7; NAE1; HIST1H3C; HIST1H4F; PPP1CBL; LIMK2; H2AFB2
    protein kinase binding PIWIL1; MAPT; MAG; EEF1A2; TBL2; CCNB3; SUFU; PTPRR; EEF1A1; TOM1L1
    protein phosphatase 2A binding PPP2R4; RPS6KB1; ARPP19; PPP2R2A; MASTL; FOXO1; ENSA; SPHK1; SHC1; PTPN1
    protein phosphatase binding TP53; EIF2AK3; PPARG; CTNNB1; JUP; DLG4; ANAPC4; SKAP1; Itga10&Itgb1; FLT4
    protein self-association TRIM32; ABCD3; LDB1; AGA; MALT1; EPB49; AXIN1; CCDC88C; RYR2; TP53
    receptor tyrosine kinase binding PIK3R2; ANGPT4; PCNA; MYOC; PLCG1; SHC4; LRP4; GNB2L1; ZFP259; HYAL2
    sequence-specific DNA binding ZNF500; TAF2; NR6A1; ZSCAN16; RXRGA; ZKSCAN14; MKXB; HSFX1; MSXE; EVX2
    transcription cofactor binding TRP53; FOXO3; CHD6; KLF4
    transcription factor activity, sequence-specific DNA binding MXD1; CBFA2T2; YY1; ZNF41; HOXD3; LMX1B; E4F1; ZFP354A; TFAM; KLF9
    transcription factor binding NKX2; JUNB; NAB2; PAXBP1; ID1; POU5F1; TFDP2; STAT3; SUFU; SORBS3
    transcription regulatory region DNA binding KLF17; FOXA2; ARID4A; AIRE; ASH2L; JUND; TBP; MTERF3; SALL1A; NR1H3
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PLAG1; SOX12; MEOX1; MEIS1; ETV4; JUN; GATA2; ZFP292; TCF12; POU4F1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GATA2B; MYOG; MAFG; FEZF2; OVOL2; PKNOX1; CTCF; GATA2A; MAFBB; GATA4
    ubiquitin protein ligase binding MDM2; USP13; SNCAIP; NPLOC4; RAD18; UBE2G2; UBE2G1B; UBOX5; MAP1LC3C; GABARAPL1

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40; atp; Mdm2

    Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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