Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis PRKACB,CREB3L2,H2BFWT,TBPL1,HIST1H4H,HIST1H4M,HLA-A,NFKB2,YWHAE,MAPKAPK2
    Endometrial cancer PIK3CD,TP53,LEF1,AXIN1,ARAF,PIK3R3,MAP2K1,BAD,GSK3B,PIK3CG
    Herpes simplex infection STAT1,BMA2,HLA-B,IFNA5,PER3,CCL5,IL12A,C3A.2,PPP1CB,TBPL1
    Melanoma NRAS,HGF,Fgf15,FGF20,PDGFA,FGF7,FGF5,PDGFC,FGF6,FGF10
    Cell cycle HDAC2,MYCA,CEP135,NIPBL,CDK6,ORC4,CDC25B,FGFR1OP,CLIP1,VRK2
    Epstein-Barr virus infection NFKBIA,POLR2I,RAN,POLR3C,Fcer2a,FCER2,PRKACB,SHFM1,CD44,AKT1
    HTLV-I infection DVL2,TRP53INP1,FZD10,PDGFA,PIK3R2,HLA-DMA,PPP3CA,PRKACB,KAT2A,CRTC3
    Pathways in cancer WNT8B,CBL,BIRC3,TRAF5,PRKACA,MITF,CXCL12,FGF8,STK4,FGF3
    Hepatitis C OAS1B,RAF1,TBK1,CLDN15,RXRA,MAPK10,IFNA13,CLDN2,AKT1,SCARB1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    p53 binding ZFP385C,USP10,SETD8,TP53,TAF3,TP63,TP53BP1,GSK3B,TP53RK,CHD8
    RNA polymerase II transcription factor binding T,MKX,TOX2,SMAD4,NFATC1,GATA5,CREBBP,TP53,TRPS1,GATA1A
    DNA binding SSH2,H2AFY,HOXC5A,BHLHA15,BRIP1,ZNF763,SPRTN,CDX1B,POLR2I,POU3F2A
    protein phosphatase 2A binding SHC1,AKT1,MASTL,STRN4,CPD,ENSAA,PPP2R4,EIF4EBP1,FOXO1,SPHK1
    copper ion binding DBH,COX17,LOXL3B,F5,CUTC,TYRP1B,P2RX2,ABHD1,CP,POLR1B
    MDM2/MDM4 family protein binding PSME3,CAV1,PPARA,RFWD3,CDKN2A,CDK5RAP3
    chaperone binding AHSA1,DLST,ST13,TSACC,ATP1A3,INS1,HYOU1,BAG4,CDKN1B,GNB5
    protein kinase binding DPYSL2,KIF11,ELP2,SHC1,FER,MAG,PTPN23,SMAD1,MEF2A,SFN
    damaged DNA binding PCNA,RAD23A,XPA,RPA2,RUVBL2,H2AFX,EP300,FEN1,REV1,DCLRE1A

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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