Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection CLOCKB,IFNA5,HLA-DOB,TAF3,GLTSCR2,EIF2AK3,PPP1CA,MCRS1,IFNB,HLA-DOA
    Sphingolipid signaling pathway TRADD,MAPK10,NRAS,PPP2CB,PPP2R5E,RAF1,GAB2,KRAS,PPP2R5A,MAP2K2
    Neurotrophin signaling pathway MAGED1,BAX,MAPK3,CALML3,NGFR,NGF,PSEN2,PDPK1,NFKBIB,RPS6KA3
    MAPK signaling pathway PPP3CCA,PPM1BA,MAP4K1,GRB2A,RAC3B,PTPRR,PDGFRA,CACNB4A,HSP70,PDGFAB
    Non-small cell lung cancer GRB2,PRKCG,MAP2K2,HRAS,RXRG,RXRB,CCND1,PDPK1,PIK3CD,EML4
    PIK-Akt signaling pathway CCND2,YWHAH,ITGB3,FGF10,NRAS,TCL1B1,ITGA6,RAF1,IL2RB,GNB1
    Transcriptional misregulation in cancer SSX1,ETV6,KLF3,TMPRSS2,TRAF1,WHSC1,GOLPH3L,GOLPH3,HOXA9,CCNT2
    MicroRNAs in cancer EP300,TNXB,RAF1,SHC1,ABCC1,IRS1,THBS1,CCNE1,EZH2,CCNE2
    Small cell lung cancer ITGB1,RB1,SKP2,LAMB2,IKBKG,ITGA3,RXRB,LAMC1,PIK3CG,NFKBIA

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TFAM,NFIA,SOX12,FOSB,NOBOX,RFX4,SREBF1,ESRRA,SOX2,ARNT2
    transcription factor binding ARHGEF2,PPID,PITX2,PPRC1,PPP1R13L,SP1,SIRT1,UBE2I,JUND,DIP2C
    histone acetyltransferase binding TAF7,CREB1,KAT2B,TP53,MYOCD,HIF1A,TRIP4,TRIM68,PAX6,FOXP3
    core promoter sequence-specific DNA binding THRAP3,ATF4,PRMT5,REST,NRIP1,C1orf51,NRF1,SP1,CREM,NR1D2
    metal ion binding FOXP1B,ZNF41,NME7,ZNF189,BCL11AA,ZNF488,DAGLB,ZBTB1,ZUFSP,CYP7A1A
    transcription regulatory region DNA binding ZNF831,KDM1A,RFX3,SALL3B,CREB3L2,KLF11,RFX6,WNT5A,ATMIN,ARID4A
    ubiquitin protein ligase binding WASH1,PER3,NLK,GPI,MAP1LC3C,TRIOBP,TMBIM6,SCN5A,UBE2T,WFS1
    histone deacetylase regulator activity MAPK8,NCOR1,TP53
    protein N-terminus binding SLC6A3,ERCC6,SDCBP,ERCC2,HESX1,SUV39H1,NCOA3,RPA2,ZWINT,APTX

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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