trp53
Share
  • Official Full Name
  • transformation related protein 53
  • Synonyms
  • bbl; bfy; bhy; p44; p53; Tp53
Cat.#:TRP53-17432MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRP53 Protein
+Inquiry
Cat.#:Trp53-5632MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Trp53 protein, His-tagged
+Inquiry
Cat.#:Kit-2107Tag:
Source (Host):Species:
Product namep53 Transcription Factor Activity Assay Kit
+Inquiry
Cat.#:Kit-0642Tag:
Source (Host):Species:
Product namep53 Translocation Assay Kit (Cell-Based)
+Inquiry

Involved Pathway

Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG6; ARR3A; FGF12A; Fasl; KCNA3; PLA2G4A; SOS1; GNA12A; PAK2; LAMTOR3
Sphingolipid signaling pathway
PIK3R5; HRAS; MAPK12; PIK3CB; DEGS2; FYN; MAP3K5; BID; SGMS2; TNF
Cell cycle
GSK3AA; KIF18A; TMPO; TUBGCP2; CCNE1; RBL1; CDK4; VRK2; NCAPH2; MCM7
p signaling pathway
GADD45BA; CASP3B; TP53I3; CASP8; CCNE2; PTENB; PMAIP1; SIAH1A; CDK1; SIAH2L
PIK-Akt signaling pathway
PTK2; IL2RG; LAMA2; INS2; ITGA4; MET; VEGFB; PPP2CB; ITGA3; IL7R
Apoptosis
IL1B2; H1F0; PRKAR1B; RIPK1; E2F1; PPP3R1B; PRKACG; HELLS; TNFRSF1A; CASP12
Wnt signaling pathway
CUL1; CAMK2B; CUL1B; SOX17; MYCB; RBX1; NKD1; TCF7L1A; CTNNBIP1; SMAD3
Neurotrophin signaling pathway
CALM1; RELA; TRAF6; FOXO3; GSK3B; NTRK1; SOS1; MAP2K7; RAP1B; PRDM4
Thyroid hormone signaling pathway
GATA4; MED13; NOTCH1; MED1; NRAS; THRB; SLC16A10; ATP1B3; MED14; ATP1B2
Amyotrophic lateral sclerosis (ALS)
GPX1; RAC1; CCS; GRIA1; GRIN2C; TNF; CASP1; PPP3CA; TNFRSF1B; APAF1
Huntingtons disease
DCTN1; PLCB1; DNAIC2; GRIN1; TBPL1; POLR2F; ITPR1; DNALC4; CASP9; UQCRQ
Hepatitis C
NRAS; TRAF2; CLDN18; SOS1; PIAS1; Ifna11; AKT2; TRADD; RAF1; IFN-a
Hepatitis B
EGR3; IFNA2; PIK3R3; STAT4; FAS; NFKB1; IFIH1; AKT1; PIK3CA; STAT6
Measles
IFNA10; TNFRSF10D; FAS; RELA; IL1A; DOK1; IFNAR2; PIK3CG; MAVS; FASLG
HTLV-I infection
AKT1; HLA-DPB1; WNT8A; CCND3; TBP; TBPL2; APC; FOS; VCAM1; FZD2
Herpes simplex infection
C3A.2; IFNA5; IL1B; SRSF4; IRF3; IFNA4; HLA-C; SFRS9; PPP1CC; SRSF7
Epstein-Barr virus infection
CD40; NFKB2; HDAC5; GSK3B; HLA-DRA; HSPA1B; MAP2K7; PIK3CD; HLA-DQA1; CCNA1
Pathways in cancer
IL6; BAD; SMO; MAX; MAPK8; FASLG; FGFR1; CSF3R; RELA; KRAS
Transcriptional misregulation in cancer
MAX; SIN3A; HOXA11; SS18; Itgam&Itgb2; GZMB; ELK4; HDAC2; CD14; SMAD1
Viral carcinogenesis
SNW1; HDAC11; MAD1L1; H2BFWT; HDAC9; RAC1; SCIN; HIST1H4H; RBL2; HLA-B
Proteoglycans in cancer
THBS1; FLNA; PTCH1; TGFB2; WNT16; TIMP3; FZD7; WNT9A; ACTB; PLAUR
MicroRNAs in cancer
HRAS; SPRY2; STMN1; SOCS1; SIRT1; FOXP1; Pdgfa&Pdgfb; IRS2; ROCK1; BAK1
Colorectal cancer
BAD; KRAS; PIK3CA; BIRC5; GSK3B; TGFBR1; PIK3R1; MAPK3; BCL2; AXIN2
Pancreatic cancer
PIK3CG; PLD1; RAC2; PIK3CD; MAPK9; IKBKG; TGFB1; RALB; TRP53; IKBKB
Endometrial cancer
APC2; PIK3R1; NRAS; CTNNA3; BAD; ARAF; CTNNA2; APC; PIK3CB; AXIN1
Glioma
TGFA; PIK3CB; TP53; AKT2; MAPK3; HRAS; BRAF; PDGFA; PIK3R1; PIK3CA
Prostate cancer
PDGFD; PIK3CD; HSP90B1; LEF1; INS; CCND1; CREB5; FOXA1; RELA; NFKB1
Thyroid cancer
BRAF; TFG; PAX8; CCND1; CDH1; NCOA4; MAPK3; MAP2K1; RET; RXRB
Basal cell carcinoma
AXIN1; DVL3; WNT9B; WNT2; LEF1; TRP53; BMP4; PTCH1; SETD6; Fzd4
Melanoma
PIK3R2; BAD; PDGFRB; PIK3CD; FGF6; FGF8; FGF22; MDM2; MET; IGF1R
Bladder cancer
VEGFA; MAPK1; BRAF; TRP53; CDKN2A; DAPK2; CDH1; E2F3; HBEGF; CCND1
Chronic myeloid leukemia
TGFBR2; IKBKB; PIK3R2; BCR; SMAD4; PIK3R1; TRP53; AKT1; RAF1; CRK
Small cell lung cancer
FN1; LAMB2; TP53; APAF1; PIK3CA; TRAF6; PIK3R1; LAMA1; PTEN; LAMC2
Non-small cell lung cancer
RAF1; RASSF1; AKT1; PIK3R3; TGFA; BAD; FOXO3; PRKCG; RXRG; PIK3CD
Central carbon metabolism in cancer
HK1; SLC2A1; SLC16A3; PIK3CD; MAP2K1; AKT2; PTEN; PIK3R2; SIRT6; PFKM

Protein Function

Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCB6A; SNRK; NAT1; TRIP13; PIP5K1B; DDX19A; RAD50; PLK4; SMC1AL; PRKD1
Function DNA binding
Related Protein MIER3; FUS; SPHK1; SMUG1; JUNB; VEPH1; NR2F1A; EME1; KIF22; RORCA
Function MDM2/MDM4 family protein binding
Related Protein PPARA; PSME3; TRP53; RFWD3; CDKN2A; CAV1; CDK5RAP3
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein RUNX2; ZNF277; H3F3A; STAT5A; NR4A2; ZFP335; SPI1; TCF7L2; YAP1; SOX3
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein MYOD1; SOHLH1; GATA2B; MNT; MEF2D; CREB3L4; POU3F4; ATF3; ZBTB16A; PLAGL1
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein POU5F1; SOX9B; PAX6; HIF1AL2; FOXB1; RUNX3; TP73; PAX6A; ELF5; SOX30
Function RNA polymerase II transcription factor binding
Related Protein GFI1B; Ar; MIXL1; GATA1; PITX2; ID4; WWP2; TBX3; GSC; GATA3
Function chaperone binding
Related Protein DNAJA1; C1orf182; ATP1A2; AHSA1L; HSPA5; TP53; CTSC; SERPINA7; TFRC; TSACC
Function chromatin binding
Related Protein EP300; TFAM; UBTFL; NFATC3; SOD3; APBB1; JUB; PHF13; CTBP2; PROP1
Function copper ion binding
Related Protein PAM; ATP7B; LOXL2; MT3; SNAI3; SLC11A2; S100U; POLR1B; IL1A; CUTC
Function core promoter sequence-specific DNA binding
Related Protein CHD2; ZFP750; SOX1; ZNF750; ZFHX3; SOX9; MLL1; CREM; RORA; PROX1
Function damaged DNA binding
Related Protein POLI; TDG; XRCC5; GTF2H3; TP63; TP53BP1; CREBBP; TRP63; H2AFX; RAD23B
Function double-stranded DNA binding
Related Protein MCM10; CGGBP1; TARDBP; HMGB1; ZNF638; KLF6; RAD51; HNRNPDL; MTERF; RAD51D
Function enzyme binding
Related Protein BIRC5; NLRP1; RCOR3; BCHE; HIST1H2AD; PTPLAD2; KDM4C; SIRT3; PTPN1; PRKCE
Function histone acetyltransferase binding
Related Protein MTF1; KAT2B; EPAS1; SP1; MEF2A; ZBTB7A; CITED2; TAF7L; TP53; EID1
Function histone deacetylase regulator activity
Related Protein NCOR1; MAPK8; TP53; TRP53
Function identical protein binding
Related Protein CEP57L1; CEP72; CHEK2; DVL2; RGMB; WRNIP1; HCFC1; MAP3K13; CSK; COL18A1
Function metal ion binding
Related Protein CBFA2T3; ZFP82; Acsm2a; Trf; ZIC5; ZKSCAN4; ALPPL2; ADNP2; TERT; GALNTL6
Function p53 binding
Related Protein TRP53; CDKN2A; KDM1A; MAPKAPK5; TRIM24; SMARCB1; MDM2; SMARCA4; TP73; TP53BP1
Function protease binding
Related Protein ITGA3; COMP; FN1; SELL; BCL10; CHL1; MBP; DPP4; SERPINB3; INS
Function protein C-terminus binding
Related Protein CLIC6; TAX1BP3; SNF8; HOMER3; HIC2; MSH2; FOXN3; PRDX3; KPNA3; ERCC4
Function protein N-terminus binding
Related Protein DCTN4; TRP53; NCOA1; MYO7A; MECP2; RPA2; VWF; HAX1; ALOX5AP; THAP7
Function protein binding
Related Protein BEX1; TNFRSF14; USP18; FADD; CCP110; HSP90AB1; HAND1; DHX58; RNF6; HSPBAP1
Function protein heterodimerization activity
Related Protein KCNH5; TYRO3; SRY; KCNIP1; SMC4; USF2; ITGB1; BCL2; FLOT1; BAXB
Function protein kinase binding
Related Protein SFN; CDC25B; MAPK8IP2; TP53; XBP1; HNRNPA0; CCNT2A; PXN; KCNH1; RAD9
Function protein phosphatase 2A binding
Related Protein RPS6KB1; STRN4; EIF4EBP1; SHC1; ARPP19; GRIN3A; SMG7; TRP53; IGBP1; SPHK1
Function protein phosphatase binding
Related Protein ROS1; FLT4; PARD3; CDH2; TRAF3; STAT3; TRAF2; JAK3; CDH5; MVP
Function protein self-association
Related Protein ADAM8; CBR2; TP53; TMEM190; ZKSCAN17; SHANK3; BCL10; SVIP; LDB1; TTN
Function receptor tyrosine kinase binding
Related Protein PTPN2; ANGPT1; SQSTM1; GAS6; HYAL2; DNAJA3; FIZ1; NRG3; SOCS5; PITPNM3
Function sequence-specific DNA binding
Related Protein POU3F3B; HOXB3A; RXRAA; OTPB; FEV; MEOX1; VSX1; FOXE3; GATA1A; HOXD13A
Function transcription cofactor binding
Related Protein CHD6; TRP53; FOXO3; KLF4
Function transcription factor activity, sequence-specific DNA binding
Related Protein RFXAP; PURBA; CTNNB1; ZNF12; FLI1; PDX1; ALX1; SCAND1; FOXQ1A; FOXC1A
Function transcription factor binding
Related Protein NLRP3; HDAC8; PPP1R13BB; APBB2; DIP2B; TP73; REST; HMGB1; HHEX; CCND1
Function transcription regulatory region DNA binding
Related Protein GLI1; TP63; WNT1; ZNF567; RBBP5; NKX3; RREB1; RCOR1; ZNF821; CARM1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein FOSB; MITF; BARHL2; NFIA; SRF; CREB3L1; E2F4; NFKB2; TRP63; GATA1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ALX4; MAFBA; LMO2; PKNOX1; AIRE; GATA1; BARX1; FEZF2; TBX5; FOXF1
Function ubiquitin protein ligase binding
Related Protein TRAF4; POLR2A; PA2G4; UBE2J2; UBE2J1; ARRB1; CUL3A; RPA3; YWHAE; HSPA9

Interacting Protein

Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.
lt_sv40; atp; Mdm2

Trp53 Related Articles

Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).