Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HTLV-I infection TGFB2,RANBP1,NFKB1,WNT8A,CRTC2,POLE2,ATF3,ATF4,RAN,PDGFA
    Prostate Cancer NOXA1,TCF7L2,MAPK1,FOXA1,MTOR,MAPK3,INSRR,MAP2K1,GSTP1,CREB3L1
    Chronic myeloid leukemia TGFBR1,RB1,PTPN11,PIK3R3,TGFB1,BAD,PIK3CD,SHC1,STAT5A,KRAS
    Huntingtons disease NDUFV1,SDHC,MT-ATP6,SLC25A6,CASP9,ATP5O,COX8C,UQCRC1,POLR2J2,NDUFA9
    Hepatitis B TLR3,MAP2K4,DDX58,BCL2,STAT3,CCND1,CASP12,MAPK8,AKT2,STAT4
    Small cell lung cancer RXRB,LAMA3,FN1,CKS2,CCND1,PIK3R5,PIK3R1,SKP2,IKBKB,AKT1
    Transcriptional misregulation in cancer ID2,TP53,SMAD1,HIST1H3H,IGFBP3,PTCRA,Aff1,RXRA,RELA,DEFA3
    Wnt signaling pathway FBXW11A,RUVBL1,PPP3R1,FZD3A,ROCK2A,CAMK2B,PRKCBB,BAMBIB,CXXC4,WNT7AA
    Pancreatic cancer NFKB1,PIK3CB,RAC2,RAC1,CDC42,PIK3CD,AKT1,TGFA,RAF1,PIK3R3

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor activity, sequence-specific DNA binding ETV2,PHB,PEG3,TFDP2,TFDP3,FOXM1,ELF2B,SOX9A,SIM1B,SIX1A
    transcription factor binding PARK7,TRIB1,RELA,PIAS2,HHEX,RNF222,IFI203,PDX1,TP73,SOST
    transcription regulatory region DNA binding FOXI1,HDAC1,STAT3,CITED1,ZBTB14,FOXH1,SMARCA2,FOXA3,TCF7,SOX2
    p53 binding PTTG1IP,ZNF385B,EHMT2,DUSP26,BRD7,RFWD3,TP53BP1,BANP,TP63,TRP63
    protein phosphatase binding PPP6R1,GNB2L1,SHOC2,EIF2AK3,MAP2K7,HSF4,FGF19,PPARG,STAT6,RPA3
    protein N-terminus binding PEX19,KCNIP2,STX5,MEN1,ERCC2,VPS25,HAX1,DCN,NFE2,SMARCA4
    RNA polymerase II core promoter sequence-specific DNA binding H2AFY,ZFP335,SFPI1,SUZ12,RREB1,MAZ,NR4A2,IRF7,TFAP2A,TBR1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ETV5,GATA1,CREB3L4,BARHL1B,MAFB,GATA2A,SRF,SOHLH2,CREB3L3,HOXD8
    protein kinase binding SPDYE2,CNPPD1,GDF3,NBEA,CDK5,DVL1,THY1,BCL2L14,CEP152,KIF20A

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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