Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis IL1B2,CASP10,PPP3CCA,RIPK1L,STK26,FAS,AKT3A,FADD,TRADD,TNFRSF10B
    Epstein-Barr virus infection PSMD13,CD38,MAP2K6,POLR2J2,HLA-DRA,TRAF6,POLR3B,PSMC2,NEDD4,HSPA1L
    Sphingolipid signaling pathway RHOA,GNA12,MAPK8,SPTLC1,SPTLC3,PPP2R5B,MAPK11,PIK3CD,SGPP2,PRKCG
    Pancreatic cancer RAD51,PIK3CA,MAPK1,STAT3,MAPK10,ERBB2,BCL2L1,CASP9,NFKB1,ARHGEF6
    HTLV-I infection PPP3CA,WNT8B,IL2RB,CCNB2,CD3D,CDC23,PIK3R3,SFPI1,CD40,ETS1
    Wnt signaling pathway NLK1,PLCB1,FBXW11B,GSK3B,FBXW11A,SOST,MAPK9,CAMK2D1,RHOAA,WNT8A
    Cell cycle SSNA1,TMEM188,KAT5,CDCA8,NUMA1,SKP2,ARF1,CEP152,DKC1,YWHAQ
    MAPK signaling pathway PRKACG,HSPB1,TRAF6,PTPRR,HSPA1L,AKT1,FGF1,MEF2CA,AKT3A,PRKACAB
    Herpes simplex infection TLR3,SKP1,IFNPHI1,TNFRSF14,HCFC1B,TAF13,TLR2-2,TLR9,SRSF4,SRSF6A

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein phosphatase 2A binding MAPT,BCL2,SMG7,ARPP19,STRN4,FOXO1,GRIN3A,ENSAA,STRN,ANKLE2
    sequence-specific DNA binding MSXB,ISL2A,HOXD12,CREB3L3L,BATF,MAFGA,FOXL1,TRIM24,MTPN,MAFBB
    DNA binding TBX22,ZNF763,TBX5B,NR1I3,SPZ1,HIST1H2AG,TOX2,HMGA1,HOXD10A,HOPX
    protein C-terminus binding SDC1,OPRL1,DAB2,DLG1,NEFL,IFT52,RAD51,CDC20,ERCC1,VPS4A
    histone deacetylase regulator activity TP53,MAPK8,NCOR1
    protein phosphatase binding PIK3R1,CDKN1B,DLG3,MVP,KAT2A,STAT6,NEK2,JAK3,RPA2,MAPK14
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding FOXA1,NFKB2,NUCKS1,GATA3,GLI2,SMAD4,SIX2,SIX1,EGR1,SOX12
    protein self-association SLC2A1,S100A7A,SLC9A3R1,ABCD3,DYRK1A,AGTR1A,PROSAPIP1,PTH1R,MDH2,AXIN1
    protein heterodimerization activity HEXA,TLX1,BAX,SPNA1,TAF8,Bcl2a1b,ZFP423,ZBTB1,POLA2,CEBPE

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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