Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bladder cancer NRAS,MMP1,CDH1,CCND1,MDM2,IL-8,HBEGF,MMP1A,MAP2K1,E2F2
    Cell cycle NEK6,GINS4,E2F3,YWHAB,ANAPC11,MCM4,CDC27,CDK11B,GORASP2,MCM6
    Prostate Cancer AKT1,PIK3CD,PTEN,MAP4K1,PIK3R1,NOXA1,HRAS,TGFA,PIK3R2,TCF7
    Wnt signaling pathway WNT4,DKK1,RHOAA,CTNNBIP1,CAMK2D1,RAC3A,MAPK8,SFRP1,WNT10B,PRKCG
    Huntingtons disease COX6C,UQCRQ,SDHA,NDUFB2,NDUFAB1,UQCRC1,DNALC1,POLR2K,VDAC2,COX6B1
    Hepatitis C AKT2,IFNA6,NFKBIA,IFNA4,IFNA12,IFNA7,RAF1,CLDN3,IFNA8,TRAF6
    Herpes simplex infection SRSF2,MAPK8A,TRAF2,PKZ,IFNA17,MAPK8,MAPK10,PPP1CB,FAS,CD74
    Thyroid hormone signaling pathway PLCE1,DIO2,MAPK3,RXRA,HIF1A,PLCZ1,NOTCH3,TBC1D4,PLCB4,DIO1
    Non-small cell lung cancer ARAF,PLCG1,CASP9,RARB,PLCG2,PIK3CB,MAP2K1,PIK3CD,MAPK3,EML4

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PIP4K2A,ABCA13,AK4,BMPR1BB,OAS1B,CSNK1G2A,UHMK1,PRKD3,CSF1R,BSK146
    chaperone binding FGB,AHSA1,TSACC,DNAJB2,AMFR,BAG3,CDKN1B,CLU,BAG5,UBL4A
    sequence-specific DNA binding FOXO3A,ZNF394,MNX2B,BARHL1A,HOXD3A,HOXA13A,THRA,SP5,AHR2,EVE1
    protein self-association DVL2,ABCD3,AGTR1A,TNFAIP3,S100A7A,PTH1R,ZKSCAN17,CTSC,TMEM190,SLC2A1
    enzyme binding TSPYL1,HMGA1-RS1,DNMT3L,GOLPH3,RPA3,SIRT3,APBA3,Txn1,LAMP1,CBX1
    transcription regulatory region DNA binding NKX2-1,HOXA13,WNT5A,NKX2,NFE2L2,FOXM1,RFX3,IKZF2,ATF4,ZNF217
    RNA polymerase II transcription factor binding GATA5,WWP2,ATF4,ZFPM1,ZFPM2,PITX2,GATA2A,SPI1,TBX3,TBX20
    core promoter sequence-specific DNA binding PDX1,MTA1,MYOCD,KLF10,CREM,TOP1,SOX1,PPARG,NR1D1,ATF4
    protein heterodimerization activity HMG20B,SYT16,TIRAP,MYH7,HMG20A,H2AFB1,AGTR1A,CHRAC1,BAX,AHR

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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