Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteoglycans in cancer TFAP4,AKT2,MAPK13,FAS,PPP1R12C,KRAS,WNT6,MET,ITGA5,TIMP3
    Wnt signaling pathway PPP3CCA,ROCK2,RHOAB,PRKACA,CER1,RHOAC,WNT7A,BAMBI,MMP7,FZD7A
    Amyotrophic lateral sclerosis (ALS) MAP2K6,CYCS,BAX,NOS1,BID,PPP3R2,PPP3CB,Casp3,GRIN2A,DAXX
    Hepatitis C MAPK1,EIF2AK4,TRAF2,CLDN8,IFNA8,IFNB1,IKBKB,PIK3CD,CLDN20,PPARA
    Endometrial cancer PIK3CG,KRAS,HRAS,AKT1,TCF7L2,APC,MAP2K1,MAPK3,NRAS,AKT2
    Apoptosis CDKN2A,CAPN1A,PPP3R1B,BCL2L11,PIK3R2,HIST1H1A,ATM,PPP3CCB,IRF2A,IRF4A
    Viral carcinogenesis PMAIP1,NFKB1,IL6ST,HIST1H2BJ,HIST1H2BG,HDAC7A,GTF2H2C_2,H2BFWT,UBE3A,HIST1H2BO
    Pathways in cancer CCNE1,RUNX1,FGF16,KITLG,GNG12,IKBKG,FGF14,MLH1,RAC1,RBX1
    Bladder cancer CCND1,MAP2K1,MAP2K2,RPS6KA5,MMP9,MAPK1,TP53,DAPK2,MMP1,BRAF

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    core promoter sequence-specific DNA binding SOX4,ZNF750,H2AFY,SP1,NR1D2,TP53,ZFP750,SOHLH2,RORA,NR4A3
    RNA polymerase II transcription factor binding TP53,TOX2,XBP1,GATA2B,KLF4,GSK3B,ID4,DHX9,TBX20,ZGLP1
    transcription regulatory region DNA binding PRDM5,TP53,SOX17,XRCC6,SERPINB1A,KLF17,SALL3,SOX5,Arid4b,SNCA
    RNA polymerase II core promoter sequence-specific DNA binding STAT5A,H2AFY,EP300,SMAD1,GATA6,H2AFZ,SMYD3,ZNF277,SP3,H3F3A
    copper ion binding SOD3A,F8,POLR1B,S100A5,PAM,METTL17,PARK7,LOXL2B,PRND,PRNP
    ubiquitin protein ligase binding TANK,CUL9,USP25,TOLLIP,PER1,SLC25A5,UBXN1,RNF40,USP13,UBE2B
    MDM2/MDM4 family protein binding PSME3,PPARA,CAV1,CDK5RAP3,CDKN2A,RFWD3
    protein phosphatase 2A binding FOXO1,SMG5,EIF4EBP1,SMG7,PPP2R2A,CPD,ANKLE2,RPS6KB1,MASTL,PPME1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DLX5,CREB3,PPARA,HLTF,ETV1,SOX1,SMAD1,NRL,TRP63,PITX3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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