Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection TBP,MAP3K7,MDM2,RBPJ,YWHAZ,EIF2AK3,POLR2A,GSK3B,POLR3D,PIK3R3
    p signaling pathway BBC3,TP53I3,RRM2,CYCSB,FAS,ZMAT3,SESN2,CYCS,SFN,RPRMA
    Bladder cancer SRC,KRAS,CDKN2A,THBS1,DAPK1,E2F3,ERBB2,CCND1,MYC,E2F1
    Central carbon metabolism in cancer TP53,PIK3CB,HKDC1,PIK3CG,MAPK1,C12orf5,SLC7A5,PDGFRB,NRAS,PKM2
    Wnt signaling pathway TLE3A,FOSL1A,CXXC4,WNT11,PLCB1,BAMBI,DVL1B,DVL3A,FBXW11,WNT5B
    Neurotrophin signaling pathway CAMK2G,BDNF,CALML5,SORT1,SHC3,MAPK11,IRAK1,RPS6KA1,TP73,MAP3K1
    Glioma SHC1,CAMK2A,MAPK3,GRB2,SHC2,RAF1,CALML3,BRAF,PDGFB,CALM2
    Hepatitis B BIRC5,HRAS,IFNA12,IL-8,DDB2,IFNA6,BCL2,FOS,MAVS,STAT1
    Cell cycle CEP152,CENPJ,TUBB4B,ANAPC4,TUBGCP3,STAG1,NEK7,NEK2,PCNA,TMEM188

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding AEBP1,BARX2,ZNF711,ARHGAP35,EGR1,ZBTB12.2,GLIS1,ZFP583,SP1,MEF2C
    histone deacetylase regulator activity MAPK8,TP53,NCOR1
    transcription factor binding NKX3,IFI203,IFT172,JUNBB,KEAP1,REST,GCM1,SP100,PAXBP1,BRD7
    identical protein binding FTL,CCDC109A,SOD1,C14orf166,GRB7,EED,JMJD6,KCTD17,CALHM1,MCIN
    transcription regulatory region DNA binding YY1,REST,MTERF3,ZNF831,TRP63,HNF1A,JUN,BCOR,MTERFD1,SALL4
    receptor tyrosine kinase binding GAS6,NRG1,NRG3,FNTA,TP53,LRP4,ANGPT4,PCNA,PITPNM3,SHC4
    core promoter sequence-specific DNA binding TP53,SOX4,NR4A3,ZFP932,CRY1,TOP1,SOX9,MEOX1,RORA,MYOCD
    transcription cofactor binding CHD6,FOXO3,KLF4
    transcription factor activity, sequence-specific DNA binding IKZF1,SP140,UBN2,PFDN1,NFE2L2A,GRHL2,TBX16,CDX1B,SOLH,FOXP2

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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