Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pancreatic cancer RAC1,RAC3,AKT1,MAPK10,RAF1,VEGFA,PLD1,MAPK9,RAC2,PIK3R1
    Proteoglycans in cancer VTN,RHOA,PPP1CA,SDC4,FZD5,ARHGEF1,WNT6,ITGA2,CBLC,WNT1
    Melanoma CCND1,RB1,PTEN,TP53,MAP2K2,FGF7,IGF1R,FGF19,FGF3,FGF5
    Huntingtons disease POLR2E,NDUFA12,GNAQ,COX4I1,DNAH6,DNAL1,HTT,ATP5D,GRIN2B,ATP5O
    Non-small cell lung cancer ERBB2,FHIT,FOXO3,PIK3CB,PIK3CD,RAF1,PIK3R5,MAPK3,RXRA,PIK3R1
    Epstein-Barr virus infection PRKACB,POLR2J,MAP3K14,Fcer2a,TNFAIP3,CD38,PIK3R5,MAPK12,HDAC4,TRAF5
    Herpes simplex infection IL12B,SRSF1,CFP,HLA-DMA,HLA-F,CLOCK,HCFC1B,NFKBIB,CUL1A,IFNA17
    Bladder cancer MYC,RASSF1,MMP9,HBEGF,DAPK3,CXCL8,E2F3,IL-8,MMP1,UPK3A
    Basal cell carcinoma FZD2,STK36,DVL1,FZD9,FZD8,GLI2,WNT11,WNT3A,SMO,FZD7

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    damaged DNA binding NEIL3,RAD1,RAD23AB,H2AFX,CRY-DASH,XRCC5,RAD18,MPG,PCNA,PNKP
    protein phosphatase 2A binding MAPT,PPME1,STRN4,SHC1,GRIN3A,BCL2,IGBP1,EIF4EBP1,SPHK1,PTPN1
    protein self-association RYR2,TNFAIP3,AGTR1A,CBR2,MALT1,SVIP,CTSC,ZFP639,ZNF496,SLC9A3R1
    protein C-terminus binding ERCC1,SNX17,TJP2,YWHAQ,DBNL,YWHAB,RAD51,SAE1,ATXN2,TAE1
    sequence-specific DNA binding GATAD2AB,BPTF,DLX4B,USF2,RHOXF2,E2F1,POU5F3,HOXC6B,FOXI1,DLX4A
    enzyme binding HSPA1A,UGT1A6B,PHKG2,CYP2C19,PEX5,CAD,FOXO4,SLPI,MSH3,NOTCH3
    transcription factor binding PURA,DNAJA3,HDAC7,RB1,PSMD10,SUMO1,SLC26A5,MYBBP1A,CEBPG,SNF8
    DNA binding ZNF501,ALX3,ZNF157,HOXB13A,GTF2F2B,LIG3,PC,ZNF488,NKX2.2A,ZFP553
    metal ion binding ZYMND12,GPR39,EIF2S2,TGM2A,B3GAT3,ZSCAN12,MARCH4,ZZEF1,ANKMY2A,SAP30

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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