Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Colorectal cancer MLH1,TP53,LEF1,FOS,KRAS,BCL2,MAPK10,PIK3CA,ARAF,MSH3
    Apoptosis CASP10,PIK3R1,PIK3R3,DERL3,MYD88,BOKA,PRKAR2AA,BCAP31,BIRC7,PRKAR1AB
    Viral carcinogenesis HIST1H2BL,YWHAZ,RANBP1,PIK3R3,STAT5A,HLA-C,CREB3L1,HDAC3,RB1,YWHAE
    Non-small cell lung cancer MAP2K1,PIK3CA,FOXO3,PRKCA,MAPK1,ALK,PIK3R2,PIK3R1,RXRG,RASSF1
    HTLV-I infection DVL1,IL1R2,ELK4,HLA-DQA1,LTBR,HLA-DMA,HLA-DRB3,TNF,WNT1,FOSL1
    Epstein-Barr virus infection TBP,PRKACA,SHFM1,PSMD3,HLA-DRB4,HLA-A,YWHAB,HLA-E,CSNK2A2,TP53
    Prostate Cancer RAF1,GSTP1,RELA,INS2,MTOR,EP300,FGFR2,BRAF,GSK3B,CREB3L2
    p signaling pathway CCNG1,SERPINB5,SERPINE1,COP1,CASP3A,PPM1DA,CD82A,PTEN,CCND2A,IGF1
    Transcriptional misregulation in cancer MET,BCL2L1,IL3,SSX2,FLT1,SS18,FLI1,IL6,TAF15,PTK2

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding ZFP551,TRPS1,PAX9,EAF2,RARG,HSF2,SP1,ATF2,TFAP2E,AIRE
    copper ion binding ATP7A,LOXL5A,SNCA,ANG,CCS,HIST2H3A,TYRP1,HAMP,MT3,LOXL3B
    chaperone binding DNAJB7,PIH1D3,RNF207,HSPE1,BAG5,DNLZ,Alb,GNB5,HSPA5,PFDN4
    protein kinase binding GCSAM,PGAM1,AKAP5,PPP1CB,CDC25B,TRAF2,DLG1L,TRAP1,PDGFRB,SNAP91
    transcription factor binding IFI16,TNFRSF10A,TRIM11,HDAC8,CD34,PPP1R13BA,MECP2,NFKB1,FOXO4,TAF1
    DNA binding NKX6.1,MYCB,HOXC13,ZNF180,AGFG1,FOXB1A,NFIXB,MNDA,HOXA4A,ZFP11
    enzyme binding ITGB3,SLC12A3,TOP2B,EGFR,UGT1A1,HSPA1A,SNRPD3,CYB5A,EIF2AK3,ATF7
    chromatin binding EZH1,APITD1,CDK9,SOD3,MEIS3,PRIMPOL,RING1,WDR82,KLHDC3,TRPS1
    protein binding GPSM3,DRD1,SMC6,LARS,COMTD1,UBE2Z,NEU4,TAF10,SMARCAD1,TMEM173

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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