trp53
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  • Official Full Name
  • transformation related protein 53
  • Synonyms
  • bbl; bfy; bhy; p44; p53; Tp53
Cat.#:TRP53-17432MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRP53 Protein
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Cat.#:Trp53-5632MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Trp53 protein, His-tagged
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Cat.#:Kit-2107Tag:
Source (Host):Species:
Product namep53 Transcription Factor Activity Assay Kit
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Cat.#:Kit-0642Tag:
Source (Host):Species:
Product namep53 Translocation Assay Kit (Cell-Based)
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Involved Pathway

Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
AKT3A; PAK2B; MAPK10; KRAS; IL1R2; MAP2K2A; MAPK8IP2; MAP2K5; HSPA8; PPP3CCB
Sphingolipid signaling pathway
RAC3; S1PR2; PTEN; RAC1; SPTLC1; PLCB4; PIK3CA; PPP2R2C; SGMS2; PRKCZ
Cell cycle
RUVBL2; SMAD3B; CCNE2; HUS1; CHEK2; TUBGCP4; YWHABL; AKAP9; DBF4; ODF2
p signaling pathway
RPRMA; SESN1; SIAH2L; CYCSB; SERPINE1; TRP53; CCNG2; CCNB2; PPM1DB; RPRM
PIK-Akt signaling pathway
PPP2R2D; MTOR; MET; ITGA2; Il2; ITGA1; NR4A1; PHLPP1; ITGA6; ITGAV
Apoptosis
IRF4; RELA; STK24; SATB1; BAX; JUN; CRADD; PRKACA; IRF6; AKT1
Wnt signaling pathway
WNT6; DKK1; RAC3A; SFRP5; CCND1; FBXW11B; CCND2A; FZD7B; DAAM1; DAAM1B
Neurotrophin signaling pathway
MAPK7; PRKCD; ATF4; BRAF; ARHGDIG; RPS6KA6; MAP3K3; PLCG1; CALM3; NFKBIB
Thyroid hormone signaling pathway
PRKACA; ACTG1; MED17; AKT1; NCOR1; EP300; HIF1A; ATP1A3; PIK3R2; DIO2
Amyotrophic lateral sclerosis (ALS)
MAPK13; MAP2K3; CASP1; CASP9; TRP53; GRIN2B; NEFM; GRIN1; BCL2L1; SLC1A2
Huntingtons disease
ATP5G3; POLR2J; NDUFB5; PPARGC1A; NDUFS2; NDUFA1; NDUFC2; DNAI1; DNAIC2; CREB3L3
Hepatitis C
IKBKE; CLDN23; MAPK9; IFNB1; PPP2CA; TBK1; CD81; OAS3; RIPK1; MAPK1
Hepatitis B
HBXIP; CCNE1; IFN-a; IFNA12; STAT5A; IRF3; IL-8; IKBKG; MAPK9; BCL2
Measles
IL6; PIK3R1; CD46; TRP53; BBC3; IFNA4; MX1; IFNGR1; RAB9B; IL2RB
HTLV-I infection
WNT3A; MSX1; PPP3CC; VCAM1; PIK3R2; TP53INP1; WNT10B; TBP; POLE2; ATF1
Herpes simplex infection
TAF5; HLA-DMB; IFNA6; HNRPKL; MHC2A; HMGN1; OAS1B; IKBKG; TNF; TAP1
Epstein-Barr virus infection
PSMD1; MAPK12; SPN; EIF2AK3; HSPA1L; EIF2AK2; XPO1; POLR3GL; PSMC2; HLA-DRB4
Pathways in cancer
MSH6; GLI3; PDGFB; FGF12; LAMA2; CASP8; WNT8B; RB1; RASSF1; GSTP1
Transcriptional misregulation in cancer
SMAD1; IGF1R; REL; MEIS1; CLSTN2; MMP3; MYCN; MLLT1; CEBPE; RUNX1
Viral carcinogenesis
HDAC7; ATP6V0D2; HLA-E; SRF; MAD1L1; HDAC1; PIK3R1; HLA-C; CCND3; GTF2H3
Proteoglycans in cancer
SOS1; NANOG; PDCD4; VTN; HSPG2; DROSHA; PLCG1; WNT9B; PIK3CG; EZR
MicroRNAs in cancer
RAF1; CCNG1; Casp3; HDAC4; HOXD10; BRCA1; BCL2; RPTOR; SPRY2; ZFPM2
Colorectal cancer
APC2; Casp3; AKT2; TGFBR2; MAPK1; BCL2; MSH2; MAPK10; FOS; PIK3CB
Pancreatic cancer
BCL2L1; SMAD4; CCND1; PIK3CD; PIK3R2; AKT1; MAP2K1; KRAS; TGFBR2; PIK3CA
Endometrial cancer
TRP53; MAP2K1; PIK3R2; ILK; CASP9; RAF1; TCF7; PIK3R5; PIK3CA; TP53
Glioma
PLCG2; SHC4; PIK3CG; ARAF; TRP53; RAF1; HRAS; KRAS; CAMK2G; CALML3
Prostate cancer
HSP90AA1; AKT2; RB1; Pdgfa&Pdgfb; MAP2K2; IKBKB; MTOR; TRP53; PIK3R2; MAPK1
Thyroid cancer
MAP2K2; CDH1; CCDC6; TRP53; CCND1; KRAS; TFG; NCOA4; RET; RXRA
Basal cell carcinoma
PTCH2; LEF1; HHIP; PTCH1; AXIN1; AXIN2; TP53; TRP53; DVL3; Fzd4
Melanoma
IGF1; FGF9; PIK3CG; FGF6; FGF3; PDGFRA; BAD; FGF1; PIK3CA; FGF19
Bladder cancer
MMP1A; CDKN2A; CXCL8; TP53; MAP2K1; NRAS; MDM2; BRAF; MAPK3; RPS6KA5
Chronic myeloid leukemia
TP53; CBL; MDM2; PIK3CB; PTPN11; GRB2; ABL1; MAPK1; TGFBR1; GAB2
Small cell lung cancer
TRP53; LAMC2; AKT2; TRAF1; RXRG; LAMA4; LAMA3; COL4A1; PTK2; BIRC2
Non-small cell lung cancer
PLCG1; TRP53; EML4; KRAS; NRAS; AKT2; CCND1; RB1; PIK3CG; PRKCA
Central carbon metabolism in cancer
ERBB2; PIK3CB; SLC16A3; G6PDX; PDGFRB; GLS2; SLC7A5; PIK3CG; FGFR3; HK3

Protein Function

Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NME2; PKM; NLRP4E; TRIB3; SRC; ACTBL2; ABCC10; UBE2E2; ADRBK2; TNNI3K
Function DNA binding
Related Protein PPP1R10; MAFBA; POLR2C; EF1; HIST2H3C; HOXB6A; PHC2B; HIST1H2BL; CEBPG; ZNF621
Function MDM2/MDM4 family protein binding
Related Protein TRP53; PSME3; PPARA; RFWD3; CDKN2A; CDK5RAP3; CAV1
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein EP300; GATA3; SFPI1; H2AFZ; STAT5A; RREB1; GATA1; TP53; NR4A2; IRF7
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein TBX5; XBP1; ZNF812; MNT; ALX4; DBP; HMX3; ZBTB11; ATF5; SKINT8
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein RUNX2; FLI1; FOXD4L1; POU5F1; PLAGX; FOXH1; ZNF202; FOXN1; FOXR2; JUNBB
Function RNA polymerase II transcription factor binding
Related Protein PITX2; ANKRD1; GSC; TP53; TBX6; KLF4; GFI1B; ZFPM2; TRPS1; ZFPM2A
Function chaperone binding
Related Protein UBL4A; BAX; AHSA1; DNAJB5; HSCB; DNAJB2; TBCA; SLC25A17; TFRC; DNAJA3A
Function chromatin binding
Related Protein IFT74; SP110; GLI1; KDM6B; MCMBP; ATF5; SMAD2; ANKRD2; ING2; ATXN7
Function copper ion binding
Related Protein SCO2; F8; SLC11A2; MT3; HEPHL1A; LOXL2B; CCC2; AOC1; S100U; RNF7
Function core promoter sequence-specific DNA binding
Related Protein H2AFY; GATA3; SIRT1; THRAP3; SOHLH2; SOHLH1; SOX9; ZFP932; MYOCD; ATF4
Function damaged DNA binding
Related Protein TP63; FANCG; HMGB1; APEX1; ERCC1; POLI; XRCC6; MPG; XPC; RAD18
Function double-stranded DNA binding
Related Protein NKX2-8; SP1; RAD51L1; TP63; MEN1; MTERF3; MTERF; YBX1; MRE11A; APTX
Function enzyme binding
Related Protein CYB5A; IL6R; GSTM7; RAD9; Il6ra; CRB2; TOP2A; ERN1; ACAT1; CBS
Function histone acetyltransferase binding
Related Protein MTF1; MEF2A; FOXP3; TRIP4; CITED2; TRP53; CEBPB; HIF1A; PCNA; CREB1
Function histone deacetylase regulator activity
Related Protein MAPK8; NCOR1; TRP53; TP53
Function identical protein binding
Related Protein HNRNPC; DLC; SNCA; HOOK3; MCPH1; CST3; IFI16; STK10; AHCY; PITX2
Function metal ion binding
Related Protein GDPD4; ZKSCAN3; ZIC6; ZNF493; DPEP3; CLCA2; COL2A1; NSF; ZC3H8; ATP5S
Function p53 binding
Related Protein TP53RK; PTTG1IP; AAAS; SMYD2; TRIAP1; NTRK3; ZNF385B; ZMAT4; KDM1A; SETD7
Function protease binding
Related Protein CAST; TIMP2A; NFRKB; ALPI; CCBE1; ITGA3; SERPINA1A; FURIN; HSPD1; CNTNAP2
Function protein C-terminus binding
Related Protein SP1; ATP2A2; VGLL2; PRDX3; CALCOCO1; DGKZ; MAP3K7; ERCC1; MYO1C; PQBP1
Function protein N-terminus binding
Related Protein PEX19; ATM; GLRX; MNAT1; NIPBL; PIAS3; TDRD7; RBPJ; SCT; EIF5A
Function protein binding
Related Protein PDLIM7; DAPK1; NCBP1; NGF; PLEKHO1; FAM86C; ENTPD1; PIWIL1; MALT1; TJP2
Function protein heterodimerization activity
Related Protein MYF6; H2AFB1; CHRNA5; RALGAPA2; TRP53; TXLNG; HIST1H4H; BCL2A; HIST1H4F; CXCL13
Function protein kinase binding
Related Protein MSH2; PRKAG3; FGF19; TEX14; BCAR1; MAP3K1; GATA6; SPDYE2; NEK9; KCNQ3
Function protein phosphatase 2A binding
Related Protein CTTNBP2NL; EIF4EBP1; STRN4; SMG7; MAPT; ENSA; FOXO1; MASTL; CPD; TP53
Function protein phosphatase binding
Related Protein CDKN1B; NEK2; ANAPC4; PPME1; PPP1R3C; VCP; PPP6R1; STAT6; SHOC2; ITPR1
Function protein self-association
Related Protein AGTR1B; MALT1; TRP53; CNTN2; ZNF496; CBR2; LDB1; AGXT; ABCD3; ZKSCAN17
Function receptor tyrosine kinase binding
Related Protein PCNA; Flt3l; ZFP259; CPNE3; GAS6; GNB2L1; DOCK4; FLT3LG; ANGPT2; TP53
Function sequence-specific DNA binding
Related Protein NFIL3-2; ZBTB33; POU5F1; HOXB7A; HSF4; PBX2; GZF1; NR1D1; SIX4; PPARA
Function transcription cofactor binding
Related Protein FOXO3; KLF4; CHD6; TRP53
Function transcription factor activity, sequence-specific DNA binding
Related Protein TCEAL1; HOXA3A; IKZF2; TSC22D4; NFE2; ZNF548; SALL1; NR1D1; GATA2A; ZNF287
Function transcription factor binding
Related Protein TRERF1; PPARGC1A; MDFIC; HES3; KAT2A; FLNA; LMO4; SMARCD3; MLXIPL; MECP2
Function transcription regulatory region DNA binding
Related Protein ZFHX3; BASP1; TAF7; BCL11B; TBX21; WNT5A; TP73; PAX2; KLF2A; NFKB1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HIF1A; ZIC1; NOBOX; NFKB2; SREBF1; FOXL2; MTF1; SOX1; MZF1; TFAP4
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein STAG1; CSRNP2; MYOG; MAF; ZGLP1; MYOD1; ATF1; ESRRG; TP53; ETV5
Function ubiquitin protein ligase binding
Related Protein TRAF5; TRIB1; UBE2J1; WASH; GSK3B; RRAGA; GABARAPL2; HM13; UBE2S; UBE2Z

Interacting Protein

Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.
lt_sv40; atp; Mdm2

Trp53 Related Articles

Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).