Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MicroRNAs in cancer Pdgfa&Pdgfb,DNMT3B,ST14,SHC1,PRKCE,RASSF1,NFKB1,ATM,GLS,CCNE1
    Colorectal cancer MSH2,KRAS,CASP9,TP53,Casp3,AXIN2,TGFB3,SMAD2,PIK3CD,CYCS
    Non-small cell lung cancer PRKCG,AKT1,FOXO3,SOS1,PIK3CG,AKT2,ARAF,ERBB2,ALK,PIK3R3
    Cell cycle CCNB3,MPEG1,ODF2B,MCM6L,LIN52,CCNE1,MYCA,ODF2,SET,CENPH
    Pathways in cancer WNT6,GNAQ,F2R,PDGFRB,FGF18,ITGAV,LPAR2,AKT2,TGFB1,BID
    Chronic myeloid leukemia PIK3R3,TGFBR2,TGFB1,AKT2,CRKL,SHC2,RUNX1,PIK3CB,BCR,CDK6
    HTLV-I infection POLE,TRP53INP1,XBP1,WNT3A,HLA-DMA,SFPI1,TERT,HLA-DQB1,HLA-B,CCND2
    Prostate Cancer CCNE1,PDGFA,NKX3,CREB3L1,IGF1R,INS,PIK3CB,PDGFRA,HSP90AB1,MAPK3
    Endometrial cancer APC2,TCF7,CASP9,PIK3CA,CDH1,PIK3R5,APC,CTNNA2,HRAS,MAP2K2

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein phosphatase 2A binding PPP2R4,BCL2,AKT1,SPHK1,ENSA,HMGCR,MASTL,STRN4,FOXO1,CTTNBP2NL
    ATP binding DDX11,ATP2C1,BMPR1AB,DNAH14,CDKL2,MYH3,MCCC2,GK2,BAT1,TEX14
    sequence-specific DNA binding HOXA7,HNF1B,ELF2A,BCL11B,POU2F2,FOXN2,ZNF215,NKX3.2,FOXI3B,NKX3.3
    chaperone binding DNAJA2L,DNAJB2,UBL4,BAG4,DNAJB1,TG,AHSA1,CLU,BAG5,SOD1
    protein self-association CBR2,TTN,PCSK9,AGTR1B,AGTR1A,SLC9A3R1,L1CAM,CCL5,AGXT,TP53
    transcription regulatory region DNA binding CITED1,KLF11,MEF2C,SNCA,NKX3,FOXC2,GABPA,TFAP2A,ZNF174,PAX8
    core promoter sequence-specific DNA binding RORA,MEOX1,MLL1,SOX4,GATA3,MYOCD,PROX1,ZNF750,THRAP3,KLF10
    chromatin binding SMC3,NFATC2,NOC3L,ZEB1,SIX1,GLI3,APBB1,BEND6,RNF20,HMGB3B
    double-stranded DNA binding ZNF638,DMC1,SP1,SETMAR,SAFB,PNKP,GTF2H4,MTERF3,NTHL1,PYDC3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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