Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis HPN,PIK3R1,PMAIP1,MRPS18B,HIST1H4N,HDAC8,HIST1H2BM,HIST1H2BD,PRKACA,RELA
    Apoptosis HIST1H1A,STK24B,NTRK1,PPP3R2,PPP3R1B,BAXB,MAP3K14,PIK3R5,PRKAR2AA,CRADD
    Herpes simplex infection IFNGR1,PPP1CB,CYCS,Ccl12,EIF2AK2,IFNGR2,HMGN1,MHC1UEA,HLA-DOB,TLR3
    Melanoma FGF16,Pdgfa&Pdgfb,FGFR1,CCND1,PIK3R1,FGF14,HGF,CDH1,PIK3R3,FGF21
    MAPK signaling pathway CACNA2D4,HSPA1A,CACNG2A,Fasl,RPS6KA3,NLK1,MAP2K4,FGF1A,MAPK8IP3,RAF1A
    Cell cycle ORC3,CLSPN,TUBG1,E2F4,CCND2,POLD3,SETA,E2F2,GADD45AB,YWHABL
    Pancreatic cancer TGFBR1,PIK3CA,TGFBR2,MAPK3,RELA,RAD51,ARHGEF6,MAPK1,RAC2,AKT2
    Endometrial cancer MAP2K1,AKT1,PIK3R2,NRAS,APC,CCND1,PIK3CA,PDPK1,MAP2K2,ILK
    Transcriptional misregulation in cancer ETV4,HIST1H3A,TGFBR2,FCGR1,HOXA10,TAF15,ATM,IL1R2,KDM6A,IGFBP3

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MRAP,GGA2,TGM1,ATP6V0C,TPM1,RAVER2,MC5R,PHYHD1,PSMD10,NPBWR2
    DNA binding TAF1L,ZNF358,THAP7,SOX32,ZNF35,GM239,NR6A1,ISX,ONECUT3,ZNF227
    sequence-specific DNA binding NKX2-8,HOXC9A,NFYBA,RARAA,PAX3A,IRX3A,BPTF,RX2,SFPI1,HOXC3A
    RNA polymerase II transcription factor activity, sequence-specific DNA binding TAL1,SP3,TFDP1A,CC2D1B,CC2D1A,FOXD4L1,FLI1B,FOXJ1B,FOXO1,FOXJ1
    p53 binding HSPD1,RNF20,ZMAT3,BRD4,SETD7,AXIN1,TAF1,TRIAP1,CDKN2AIP,CDKN2A
    transcription factor activity, sequence-specific DNA binding TEAD3,NR5A5,L3MBTL4,ZNF157,SMAD6A,MYRFL,ZNF71,NKX3,TLX2,SKINT8
    RNA polymerase II core promoter sequence-specific DNA binding SP1,SPI1,H3F3B,RUVBL2,TCF7L2,SOX3,PAX8,FOS,TP53,ZNF277
    core promoter sequence-specific DNA binding ZFP750,ATF4,TOP1,ESR2,NRF1,PRMT5,RORA,MLL1,SOX1,CREM
    double-stranded DNA binding HNRNPDL,RAD51D,HMGB3,FEV,MTERFD3,NEIL3,RAD51AP1,FEN1,USF1,DDX11

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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