Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway DKK1,FZD3A,NKD2,RAC3B,BAMBIB,CAMK2D1,LEF1,PPP3CCA,SFRP1A,WNT11
    Proteoglycans in cancer SOS1,MAP2K2,ITGB3,PPP1R12A,CAV1,ELK1,PDPK1,HSPG2,PIK3CB,PIK3R1
    Colorectal cancer PIK3R2,DCC,PIK3CG,MAPK9,MAPK10,BRAF,Casp3,FOS,LEF1,PIK3R1
    MicroRNAs in cancer GLS2,PIK3CA,CCNG1,BCL2L2,IGF2BP1,PRKCE,TPM1,HRAS,ROCK1,Abcb1b
    Thyroid hormone signaling pathway SLC9A1,ITGB3,PFKFB2,PDPK1,ACTG1,GATA4,SLC16A10,RCAN2,ATP1B3,RXRB
    Basal cell carcinoma WNT10B,DVL3,FZD2,AXIN1,SUFU,WNT16,WNT9B,SETD6,STK36,FZD3
    Cell cycle CEP290,TFDP2,CENPH,NSL1,RAD9B,CDC25A,CTDNEP1A,SMAD3,MCM6L,GINS2
    Hepatitis B STAT2,TGFB2,MAPK9,IFNA8,IFNA21,TLR3,RB1,IFNA7,Ifna11,APAF1
    Small cell lung cancer PTK2,RELA,AKT2,ITGA3,LAMC1,NFKBIA,MAX,CASP9,RXRA,CCNE1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    damaged DNA binding RPA2,APTX,BRCA1,RAD1,HMGB2,ERCC3,RAD23A,GTF2H3,DCLRE1C,TP73
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GRHL3,STAG2,TP53,MSGN1,LEF1,MAFBB,PPARG,FEZF2,NHLH1,ETV5
    double-stranded DNA binding FEV,EGFR,ZNF638,TDG,PIN4,MTERF2,PNKP,MTERFD2,TP73,RAD51L1
    core promoter sequence-specific DNA binding PRMT5,NRF1,ESR2,GATA3,MLL1,MYOCD,SOHLH2,ZFP750,SIRT1,MEOX1
    enzyme binding KPNB1,RPA2,CPSF1,LDB1,THRB,CYP2A4,CLSTN2,CTNNB1,PICK1,CD40
    protein kinase binding FBXO5,XBP1,PDPK1,CLTC,PTPN1,SPDYE2,MAP2K3,CD36,CCNL1,ITGB1BP1
    histone deacetylase regulator activity NCOR1,TP53,MAPK8
    protein heterodimerization activity ADRB1,HIST1H2BN,GRIN2A,MID1,POLA2,CHRNA3,KCNA3,HIST1H2AL,ALX1,H2AFY2
    protein binding SCLY,YWHAB,TTC9C,RPL7,STX4,MAP2,CAMK2D,PEX11A,PAAF1,HIST1H2AK

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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