• Official Full Name
  • Williams Beuren syndrome chromosome region 22
  • Background
  • This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found.
  • Synonyms
  • WBSCR22; Williams Beuren syndrome chromosome region 22; uncharacterized methyltransferase WBSCR22; MGC2022; MGC5140; MGC19709; PP3381; WBMT; HASJ4442; HUSSY 3; HUSSY3; WBS22_HUMAN; Williams Beuren candidate region putative methyltransferase; Williams Beuren syndrome chromosome region 22 protein; Williams-Beuren syndrome chromosomal region 22 protein; Williams-Beuren candidate region putative methyltransferase; HUSSY-3
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WBSCR22 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WBSCR22
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WBSCR22
Source (Host):Species:Human
Product nameRecombinant Human WBSCR22 293 Cell Lysate

Protein Function

WBSCR22 has several biochemical functions, for example, methyltransferase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WBSCR22 itself. We selected most functions WBSCR22 had, and list some proteins which have the same functions with WBSCR22. You can find most of the proteins on our site.
Related Protein
Function methyltransferase activity
Related Protein NSUN5; SETDB1A; C2orf56; EHMT1B; PRMT3; GART; TPMT.1; TRMT10C; TOMT; FAM86C
Function poly(A) RNA binding
Related Protein KIF1C; C1orf35; RBM6; EIF4E; EXOSC10; MRPL9; MACF1; ZNF622; NAP1L1; C14orf166

Interacting Protein

WBSCR22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WBSCR22 here. Most of them are supplied by our site. Hope this information will be useful for your research of WBSCR22.
FOS; PRKAB1; OAS1; VCP; PKN1; gltX; ssrna_ag; NPM1; Rpl35

WBSCR22 Related Articles

Verges, L; Molina, O; et al. Deletions and duplications of the 22q11.2 region in spermatozoa from DiGeorge/velocardiofacial fathers. MOLECULAR CYTOGENETICS 7:-(2014).
Gimelli, S; Chrast, J; et al. A t(7;12) Balanced Translocation With Breakpoints Overlapping Those of the Williams-Beuren and 12q14 Microdeletion Syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 152A:1285-1294(2010).