ABCD4
-
Official Full Name
ATP-binding cassette, sub-family D (ALD), member 4 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. -
Synonyms
ABCD4;ATP-binding cassette, sub-family D (ALD), member 4;P70R;P79R;ABC41;MAHCJ;PMP69;PXMP1L;EST352188
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Mus musculus
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- His
- T7
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ABCD4 involved in several pathways and played different roles in them. We selected most pathways ABCD4 participated on our site, such as ABC transporters,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | ANI_1_2390104,NOS2B,GSTK1,XDH,ACOX2,EPHX2,PEX11C,ACSL1B,FAR1,ECH1 |
| ABC transporters | ABCB10,ABCC12,ABCB11,ABCB1LB,ABCA13,ABCC9,ABCC6,ABCG8,ABCG3,ABCB9 |
Protein Function
ABCD4 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCD4 itself. We selected most functions ABCD4 had, and list some proteins which have the same functions with ABCD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAP2K2B,MKNK2A,AURKB,LANCL2,CHD4A,PLK4,NAGK,TTF2,ACTR8,NLRP3 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC9,SFRP5,ABCA6,ABCG2,DPY19L2,ABCB1A,ABCB8,ABCB5,ABCC3,Abca2 |
Interacting Protein
ABCD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCD4.
DLEU1;XRCC6;PEA15;SARAF
Resources
Related Services
Related Products
References
- Deme, JC; Hancock, MA; et al. Purification and interaction analyses of two human lysosomal vitamin B-12 transporters: LMBD1 and ABCD4. MOLECULAR MEMBRANE BIOLOGY 31:250-261(2014).
- Lee, A; Asahina, K; et al. Role of NH2-terminal hydrophobic motif in the subcellular localization of ATP-binding cassette protein subfamily D: Common features in eukaryotic organisms. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 453:612-618(2014).
