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ADCY3

  • Official Full Name

    adenylate cyclase 3

  • Overview

    This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes.
  • Synonyms

    ADCY3; adenylate cyclase 3; adenylate cyclase type 3; AC3; Adenylate cyclase type III; AC-III; adenylyl cyclase 3; ATP pyrophosphate-lyase 3; adenylyl cyclase, type III; adenylate cyclase, olfactive type;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADCY3-3173H Recombinant Human ADCY3, His-tagged E.Coli or Yeast His 1144
Human ADCY3-328H Recombinant Human ADCY3 Protein, GST-tagged Wheat Germ GST
Human ADCY3-6925H Recombinant Human ADCY3 protein, His & T7-tagged E.coli His/T7 Lys501~Asn736 (Accession # O60266)
Human ADCY3-9021HCL Recombinant Human ADCY3 293 Cell Lysate HEK293 N/A
Human ADCY3-0242H Recombinant Human ADCY3 Protein (Lys501-Asn736), N-His-tagged E.coli N-His Lys501-Asn736
Human ADCY3-3312H Recombinant Human ADCY3 protein, His-GST-tagged E.coli His/GST Lys501~Asn736
Rat Adcy3-3174R Recombinant Rat Adcy3, His-tagged E.Coli or Yeast His 1144
Zebrafish ADCY3-7540Z Recombinant Zebrafish ADCY3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • ADCY3 Related Signal Pathway

ADCY3 involved in several pathways and played different roles in them. We selected most pathways ADCY3 participated on our site, such as Activation of GABAB receptors, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Adenylate cyclase activating pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of GABAB receptorsKCNJ2A;GNGT2A;KCNJ5;KCNJ12;ADCY1;ADCY7;KCNJ15;KCNJ9;ADCY6
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsPDPK1A;ADCY3;ADCY1;NETO2;CREB1;DLG4;ADCY8;AKAP9;CAMKK1B
Adenylate cyclase activating pathwayADCY9;ADCY1;ADCY3;ADCY7;ADCY6;ADCY8
Adenylate cyclase inhibitory pathwayADCY6;ADCY7;ADCY1;ADCY8;ADCY3;ADCY9
Adrenergic signaling in cardiomyocytesPPP2R2C;CACNA2D2;ATP2B4;GNAS;TPM2;CACNB3;MYL4;PRKACA;PRKACBA
Aldosterone synthesis and secretionADCY7;PRKD3;CALML5;CAMK4;HSD3B2;SCARB1;ITPR2;ADCY8;GNA11
Aquaporin-mediated transportAQP9B;MYO5B;AQP10A;GNB3A;PRKAR1AA;ADCY9;AQP3A;AQP10B;ADCY6
Bile secretionSLC22A7;ATP1A2;OSTB;ABCC3;SLC51B;GNAS;BAAT;SLCO1A6;SLC9A3

ADCY3 has several biochemical functions, for example, ATP binding, adenylate cyclase activity, calcium- and calmodulin-responsive adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY3 itself. We selected most functions ADCY3 had, and list some proteins which have the same functions with ADCY3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingUBE2J1;MKNK2B;NLRP4E;RFC5;HSP90AA1.2;MYH10;PFKFB3;NAIP7;TAP1
adenylate cyclase activityADCY3;Adcy4;ADCY9;ADCY1B;ADCY6;ADCY2B;ADCY7;ADCY1;GNAS
calcium- and calmodulin-responsive adenylate cyclase activityADCY8;ADCY3;ADCY6;ADCY1
calmodulin bindingPCDP1;SLC8A2;MYO6;PHKA2;ADD1;ATPIF1;MKNK1;RASGRF2B;CTH
metal ion bindingKAT6A;CREB5;TRIM36;FTH1A;CDKAL1;ZIC5;TEC;FGG;ACMSD

ADCY3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY3.

Dlg4

Research Area

Related articles

Sebo, P; Osicka, R; et al. Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines. EXPERT REVIEW OF VACCINES 13:1215-1227(2014).
Pravetoni, M; Pentel, PR; et al. Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (14)

Ask a question
Could personalized medicine approaches be developed based on ADCY3 expression? 07/27/2021

Yes, personalized medicine approaches could potentially be developed based on ADCY3 expression levels. Measuring ADCY3 expression could help identify patients who are more likely to respond to certain treatments and stratify patients into specific subgroups for more targeted therapies.

Could targeting ADCY3 with drugs have potential side effects? 06/30/2021

Yes, targeting ADCY3 with drugs could potentially have side effects, as cAMP signaling pathways are involved in many cellular processes. It is important to carefully evaluate potential drugs and their effects on other cellular processes to minimize any unwanted side effects.

Could ADCY3 research lead to the development of new drugs? 01/15/2021

Yes, ADCY3 research could lead to the development of new drugs that target cAMP signaling in a more specific and effective way than currently available treatments. This could lead to better outcomes for patients with diseases related to metabolism and energy regulation.

How can ADCY3 protein be used in diagnostics? 10/26/2020

ADCY3 protein may be used as a diagnostic biomarker, as its expression may be altered in certain disease states. For example, decreased ADCY3 expression has been observed in patients with polycystic ovary syndrome (PCOS), a common endocrine disorder in women. Detecting changes in ADCY3 expression levels in patient samples could be used to diagnose or monitor PCOS.

Can ADCY3 protein be used as a therapeutic agent? 02/07/2020

ADCY3 protein is unlikely to be used as a therapeutic agent itself, as it is a large protein that would be difficult to deliver to cells in vivo. Instead, drugs that modulate ADCY3 activity or other components of the cAMP signaling pathway may be developed as therapies for various diseases.

What are some potential applications of ADCY3 protein in medicine? 09/19/2019

ADCY3 protein has potential applications in medicine for the treatment of diseases related to metabolism and energy regulation, such as type 2 diabetes and obesity. Understanding the role of ADCY3 in these diseases could lead to the development of new drug targets and treatments.

How can ADCY3 protein be used in drug discovery? 08/02/2019

ADCY3 protein can be used as a target for developing drugs that modulate cAMP signaling. High-throughput screening methods can be used to identify compounds that interact with ADCY3 or other components of the cAMP signaling pathway. These compounds can then be optimized through medicinal chemistry to create more potent and selective drugs.

What is the potential impact of targeting ADCY3 protein in drug development? 05/26/2019

Targeting ADCY3 protein or other components of the cAMP signaling pathway has the potential to lead to the development of new therapies for a variety of diseases, including metabolic disorders, cardiovascular diseases, and neurological disorders. By modulating cAMP signaling, these drugs may be able to improve various cellular processes and signaling pathways, leading to improved health outcomes for patients. Additionally, targeting ADCY3 or other components of the cAMP signaling pathway may offer a more personalized approach to treating patients with these diseases.

Can ADCY3 protein be used in gene therapy? 11/16/2018

ADCY3 protein is unlikely to be used in gene therapy, as it is a large protein that would be difficult to deliver to cells in vivo. However, gene therapy approaches that target the ADCY3 gene or other components of the cAMP signaling pathway may be developed in the future.

What role does ADCY3 protein play in metabolic disorders? 11/09/2018

ADCY3 protein has been implicated in the regulation of energy metabolism and the development of metabolic disorders such as obesity and type 2 diabetes. Studies have shown that decreased ADCY3 expression or activity is associated with obesity and insulin resistance, while increased ADCY3 expression or activity is associated with improved glucose homeostasis and insulin signaling. These findings suggest that targeting ADCY3 or other components of the cAMP signaling pathway may be useful for treating metabolic disorders.

How does ADCY3 protein modulate cAMP signaling? 08/25/2018

ADCY3 protein is an enzyme that catalyzes the conversion of ATP to cAMP, a second messenger molecule involved in a variety of cellular processes. This activity is stimulated by G protein-coupled receptors (GPCRs), which activate ADCY3 through interactions with G proteins and other signaling proteins. The resulting increase in cAMP levels can then activate downstream effectors, including protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC), which mediate various cellular responses.

Can ADCY3 protein be used as a diagnostic marker for diseases? 01/16/2018

Yes, ADCY3 protein expression levels could potentially be used as a diagnostic marker for diseases such as type 2 diabetes and obesity. This could help with early detection and better monitoring of these conditions.

What are some potential applications of ADCY3 protein? 07/17/2015

ADCY3 protein has potential applications in drug discovery, personalized medicine, and diagnostics. It can be used as a target for developing drugs that modulate cAMP signaling, which could be useful for treating a variety of diseases such as metabolic disorders, cardiovascular diseases and neurological disorders. Additionally, knowledge of ADCY3 expression and activity could be used to develop personalized medicine approaches for treating patients with these diseases. ADCY3 protein could also be used as a diagnostic biomarker, as its expression may be altered in certain disease states.

Are there any current FDA-approved drugs that target ADCY3? 01/10/2015

There are currently no FDA-approved drugs that directly target ADCY3. However, several drugs that indirectly modulate cAMP signaling have been approved for use in various diseases, such as asthma, heart failure, and glaucoma.

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