Recombinant Rat Adcy3, His-tagged

• Cat.No.: Adcy3-3174R
• Product Overview: Adenylate cyclase type 3 (Adcy3), partial

Specification

• Description: enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate .
• Source: E. Coli or Yeast
• Species: Rat
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 1144
• Purity: >90%
• Notes: Small volumes of Adcy3 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Adcy3 adenylate cyclase 3 [ Rattus norvegicus ]
• Official Symbol: Adcy3
• Synonyms: ADCY3; adenylate cyclase 3; adenylate cyclase type 3; AC3; AC-III; adenylyl cyclase 3; ATP pyrophosphate-lyase 3; type III adenylyl cyclase; adenylate cyclase type III; adenylate cyclase, olfactive type
• Gene ID: 64508
• mRNA Refseq: NM_130779
• Protein Refseq: NP_570135
• Pathway: Activation of GABAB receptors, organism-specific biosystem; Adenylate cyclase activating pathway, organism-specific biosystem; Adenylate cyclase inhibitory pathway, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion,
• Function: ATP binding; adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding; nucleotide binding

Q&As

Could personalized medicine approaches be developed based on ADCY3 expression?

Yes, personalized medicine approaches could potentially be developed based on ADCY3 expression levels. Measuring ADCY3 expression could help identify patients who are more likely to respond to certain treatments and stratify patients into specific subgroups for more targeted therapies.

Could targeting ADCY3 with drugs have potential side effects?

Yes, targeting ADCY3 with drugs could potentially have side effects, as cAMP signaling pathways are involved in many cellular processes. It is important to carefully evaluate potential drugs and their effects on other cellular processes to minimize any unwanted side effects.

Could ADCY3 research lead to the development of new drugs?

Yes, ADCY3 research could lead to the development of new drugs that target cAMP signaling in a more specific and effective way than currently available treatments. This could lead to better outcomes for patients with diseases related to metabolism and energy regulation.

How can ADCY3 protein be used in diagnostics?

ADCY3 protein may be used as a diagnostic biomarker, as its expression may be altered in certain disease states. For example, decreased ADCY3 expression has been observed in patients with polycystic ovary syndrome (PCOS), a common endocrine disorder in women. Detecting changes in ADCY3 expression levels in patient samples could be used to diagnose or monitor PCOS.

Can ADCY3 protein be used as a therapeutic agent?

ADCY3 protein is unlikely to be used as a therapeutic agent itself, as it is a large protein that would be difficult to deliver to cells in vivo. Instead, drugs that modulate ADCY3 activity or other components of the cAMP signaling pathway may be developed as therapies for various diseases.

What are some potential applications of ADCY3 protein in medicine?

ADCY3 protein has potential applications in medicine for the treatment of diseases related to metabolism and energy regulation, such as type 2 diabetes and obesity. Understanding the role of ADCY3 in these diseases could lead to the development of new drug targets and treatments.

How can ADCY3 protein be used in drug discovery?

ADCY3 protein can be used as a target for developing drugs that modulate cAMP signaling. High-throughput screening methods can be used to identify compounds that interact with ADCY3 or other components of the cAMP signaling pathway. These compounds can then be optimized through medicinal chemistry to create more potent and selective drugs.

What is the potential impact of targeting ADCY3 protein in drug development?

Targeting ADCY3 protein or other components of the cAMP signaling pathway has the potential to lead to the development of new therapies for a variety of diseases, including metabolic disorders, cardiovascular diseases, and neurological disorders. By modulating cAMP signaling, these drugs may be able to improve various cellular processes and signaling pathways, leading to improved health outcomes for patients. Additionally, targeting ADCY3 or other components of the cAMP signaling pathway may offer a more personalized approach to treating patients with these diseases.

Can ADCY3 protein be used in gene therapy?

ADCY3 protein is unlikely to be used in gene therapy, as it is a large protein that would be difficult to deliver to cells in vivo. However, gene therapy approaches that target the ADCY3 gene or other components of the cAMP signaling pathway may be developed in the future.

What role does ADCY3 protein play in metabolic disorders?

ADCY3 protein has been implicated in the regulation of energy metabolism and the development of metabolic disorders such as obesity and type 2 diabetes. Studies have shown that decreased ADCY3 expression or activity is associated with obesity and insulin resistance, while increased ADCY3 expression or activity is associated with improved glucose homeostasis and insulin signaling. These findings suggest that targeting ADCY3 or other components of the cAMP signaling pathway may be useful for treating metabolic disorders.

How does ADCY3 protein modulate cAMP signaling?

ADCY3 protein is an enzyme that catalyzes the conversion of ATP to cAMP, a second messenger molecule involved in a variety of cellular processes. This activity is stimulated by G protein-coupled receptors (GPCRs), which activate ADCY3 through interactions with G proteins and other signaling proteins. The resulting increase in cAMP levels can then activate downstream effectors, including protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC), which mediate various cellular responses.

Can ADCY3 protein be used as a diagnostic marker for diseases?

Yes, ADCY3 protein expression levels could potentially be used as a diagnostic marker for diseases such as type 2 diabetes and obesity. This could help with early detection and better monitoring of these conditions.

What are some potential applications of ADCY3 protein?

ADCY3 protein has potential applications in drug discovery, personalized medicine, and diagnostics. It can be used as a target for developing drugs that modulate cAMP signaling, which could be useful for treating a variety of diseases such as metabolic disorders, cardiovascular diseases and neurological disorders. Additionally, knowledge of ADCY3 expression and activity could be used to develop personalized medicine approaches for treating patients with these diseases. ADCY3 protein could also be used as a diagnostic biomarker, as its expression may be altered in certain disease states.

Are there any current FDA-approved drugs that target ADCY3?

There are currently no FDA-approved drugs that directly target ADCY3. However, several drugs that indirectly modulate cAMP signaling have been approved for use in various diseases, such as asthma, heart failure, and glaucoma.