ADCY6

  • Official Full Name

    adenylate cyclase 6

  • Overview

    This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.
  • Synonyms

    ADCY6; adenylate cyclase 6; adenylate cyclase type 6; AC6; ACVI; ADCY 6; ADCYB; Adenylate cyclase type VI; ATP pyrophosphate lyase 6; Ca(2+) inhibitable adenylyl cyclase; DKFZp779F075; EC 4.6.1.1; KIAA0422; adenylyl cyclase 6; ATP pyrophosphate-lyase 6; ca(2+)-inhibitable adenylyl cyclase;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADCY6-3178H Recombinant Human ADCY6, GST-tagged E.Coli or Yeast GST 1168
Human ADCY6-9409H Recombinant Human ADCY6 protein, GST-tagged E.coli GST
Human ADCY6-330H Recombinant Human ADCY6 Protein, GST-tagged Wheat Germ GST
Human ADCY6-9410H Recombinant Human ADCY6 protein, His-tagged E.coli His Val246-Gly435
Mouse Adcy6-6931M Recombinant Mouse Adcy6 protein, His & T7-tagged E.coli His/T7 Gln314~Asn501 (Accession # Q01341)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • ADCY6 Related Signal Pathway

ADCY6 involved in several pathways and played different roles in them. We selected most pathways ADCY6 participated on our site, such as Activation of GABAB receptors, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of GABAB receptorsADCY9;KCNJ5;GNGT2B;ADCY8;ADCY1;GNGT2A;ADCY3;ADCY6;KCNJ9
Adenylate cyclase activating pathwayADCY1;ADCY7;ADCY6;ADCY3;ADCY9;ADCY8
Adenylate cyclase inhibitory pathwayADCY6;ADCY1;ADCY7;ADCY8;ADCY9;ADCY3
Adrenaline,noradrenaline inhibits insulin secretionGNB5A;GNB5B;GNB3A;ADRA2C;ADRA2A;GNB3B;GNB5;ADCY6
Adrenergic signaling in cardiomyocytesCREB3L3L;CAMK2D1;KCNE1;CACNG6A;CREB3L3;MAPK14;CACNA2D2;PRKACAB;ATF6B
Aldosterone synthesis and secretionAGTR1B;PRKD1;PLCB2;CAMK2B;CYP21A1;GNAS;PRKACG;CYP11A1;LIPE
Aquaporin-mediated transportADCY6;GNB3A;ADCY1;AQP10B;ADCY3;GNB5B;GNB5;AQP10A;ADCY9
Bile secretionSLC5A1;ATP1B2;ATP1A1;SLCO1B1;ABCG2;Abcb1b;ADCY8;ATP1B4;PRKACG

ADCY6 has several biochemical functions, for example, ATP binding, adenylate cyclase activity, calcium- and calmodulin-responsive adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY6 itself. We selected most functions ADCY6 had, and list some proteins which have the same functions with ADCY6. You can find most of the proteins on our site.

Function Related Protein
ATP bindingAACS;TGFBR1A;DAPK2;TCP1;PYGL;EP400;ABCA1;KIF16B;KIF23
adenylate cyclase activityADCY9;ADCY2B;ADCY6;GNAS;ADCY1A;ADCY8;ADCY1;ADCY7;ADCY3
calcium- and calmodulin-responsive adenylate cyclase activityADCY6;ADCY3;ADCY8;ADCY1
metal ion bindingARL1;SP6;PVALB6;ZC3H12A;ZFP775;B4GALT5;ZDHHC16B;ZNF608;CSNK2B
protein bindingDHX9;DIP2A;EIF4B;ROBO1;ARL8A;GPN3;BAP1;NEIL2;PLEKHA2
protein kinase bindingTUBB3;ACVRL1;CACNB3;MS4A2;PAK2;CSPG4;DPYSL2;TRAP1;MAPK8IP2
scaffold protein bindingCACNA1H;KRT8;SHANK3;PDE4D;NOS1;NLGN4X;CACNA1G;ATP2B4;GRIN2A

ADCY6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY6.

ATXN1

Research Area

Related articles

Cunha-Reis, D; Aidil-Carvalho, MD; et al. Endogenous Inhibition of Hippocampal LTD and Depotentiation by Vasoactive Intestinal Peptide VPAC(1) Receptors. HIPPOCAMPUS 24:1353-1363(2014).
Dirix, V; Mielcarek, N; et al. Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin. MICROBES AND INFECTION 16:562-570(2014).
  • Q&As
  • Reviews

Q&As (13)

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What strategies can be used to target ADCY6 for drug development? 11/03/2022

Various strategies can be used to target ADCY6 for drug development, including small molecule inhibitors, antibodies, and gene therapy. High-throughput screening, virtual screening, and molecular dynamics simulations can be used to identify potential drug candidates. Additionally, studying the structure and function of ADCY6 can help identify new strategies for drug development.

Is ADCY6 involved in insulin secretion by pancreatic beta cells? 05/09/2022

Yes, ADCY6 is involved in insulin secretion by pancreatic beta cells. It regulates the cAMP signaling pathway in beta cells, which plays a critical role in insulin secretion. Mutation of ADCY6 has been associated with impaired insulin secretion and glucose metabolism, suggesting that it may be a potential therapeutic target for diabetes.

What approaches could be used to develop drugs that target ADCY6? 06/09/2021

Several approaches could be used to develop drugs that target ADCY6. One approach is to identify small molecules that bind to and activate or inhibit ADCY6. Another approach is to develop antibodies or other protein-based therapeutics that target ADCY6. Finally, gene therapy approaches could be used to modulate ADCY6 expression or activity in specific tissues.

Can ADCY6 be a potential target for the treatment of anxiety and depression? 05/13/2020

ADCY6 has been implicated in the regulation of anxiety and depression-related behavior in animal models. Inhibition of ADCY6 has been shown to reduce anxiety and depressive behaviors in mice. Therefore, ADCY6 could be a potential therapeutic target for the treatment of anxiety and depression.

How is ADCY6 function studied in cells and organisms? 01/27/2020

ADCY6 function can be studied in cells and organisms using a variety of techniques, including genetic manipulation, pharmacological inhibition, and biochemical assays. Genetic manipulation can involve the use of gene knockout or knockdown techniques to evaluate the effects of ADCY6 on cellular or organismal functions. Pharmacological inhibition can involve the use of specific inhibitors to block ADCY6 activity and assess its role in various physiological processes. Biochemical assays can be used to measure the activity and cAMP production of ADCY6 in response to different stimuli.

What are the potential clinical implications of targeting ADCY6? 07/24/2019

Targeting ADCY6 may have clinical implications for the treatment of various diseases. For example, drugs that target ADCY6 may have therapeutic benefits in the treatment of heart failure, hypertension, diabetes, and neurological disorders, among others. However, more research is needed to fully understand the potential clinical applications of targeting ADCY6.

Are there any drugs currently available that target ADCY6? 07/12/2019

There are no drugs currently available that specifically target ADCY6. However, several drugs that modulate cAMP levels, such as fosfomycin and cilostamide, indirectly affect ADCY6 activity.

Can ADCY6 be used as a diagnostic biomarker for heart disease? 05/26/2019

ADCY6 gene mutations have been associated with various forms of heart disease, and some studies suggest that genetic testing for ADCY6 mutations may be a useful diagnostic tool for identifying individuals at risk for heart disease. However, more research is needed to determine the extent to which ADCY6 can be used as a reliable biomarker for heart disease.

How could targeting ADCY6 be used in the treatment of cardiovascular disease? 08/16/2018

ADCY6 plays an important role in regulating cardiac function, and drugs that target ADCY6 could potentially be used to treat various types of cardiovascular disease. For example, drugs that activate ADCY6 may be useful in the treatment of heart failure, while drugs that inhibit ADCY6 may be useful in the treatment of arrhythmias.

How is ADCY6 expression regulated? 07/04/2018

ADCY6 expression can be regulated at the transcriptional, post-transcriptional, and post-translational levels. Transcription of ADCY6 is regulated by various transcription factors, such as CREB and NF-κB, which bind to the promoter region of the gene. Post-transcriptional regulation can occur through alternative splicing or modulation of mRNA stability. Post-translational regulation can occur through phosphorylation, acetylation, and other modifications that affect the activity and stability of the protein.

How is ADCY6 regulated? 09/24/2017

ADCY6 activity is regulated by a variety of signaling pathways. For example, it can be activated by G-protein-coupled receptors, which bind to the enzyme and stimulate its activity. ADCY6 can also be regulated by calcium, which binds to calmodulin and activates the enzyme. Additionally, various kinases and phosphatases can modulate the activity of ADCY6.

What are some potential therapeutic applications for targeting ADCY6? 02/14/2017

ADCY6 has been implicated in a variety of physiological processes, including cardiac function, blood pressure regulation, and glucose metabolism. As a result, drugs that target ADCY6 may have therapeutic benefits in the treatment of cardiovascular disease, hypertension, and type 2 diabetes, among other conditions.

What challenges need to be overcome in order to develop drugs that target ADCY6? 12/14/2015

One major challenge in developing drugs that target ADCY6 is the need to selectively target the enzyme without affecting other isoforms of ADCY or other components of the cAMP signaling pathway. Another challenge is to develop drugs that can effectively penetrate the cell membrane and reach the target tissue in sufficient concentrations. Finally, toxicity and off-target effects must be carefully evaluated to ensure safety and efficacy of any potential drugs.

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