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Recombinant Human ADCY6 protein, His-tagged

Cat.No. : ADCY6-9410H
Product Overview : Recombinant Human ADCY6 (Val246~Gly435) protein was fused to His-tag at the N-terminus and expressed in E.coli.
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Description : This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita.
Source : E.coli
Species : Human
Tag : His
Form : Lyophilized from sterile 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : Predicted Molecular Mass: 25.5 kDa; Observed Molecular Mass: 26 kDa.
Protein length : Val246-Gly435
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 97%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : ADCY6
Official Symbol : ADCY6
Synonyms : AC6; LCCS8
Gene ID : 112
mRNA Refseq : NM_015270.5
Protein Refseq : NP_056085.1
MIM : 600294
UniProt ID : O43306

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What strategies can be used to target ADCY6 for drug development? 11/03/2022

Various strategies can be used to target ADCY6 for drug development, including small molecule inhibitors, antibodies, and gene therapy. High-throughput screening, virtual screening, and molecular dynamics simulations can be used to identify potential drug candidates. Additionally, studying the structure and function of ADCY6 can help identify new strategies for drug development.

Is ADCY6 involved in insulin secretion by pancreatic beta cells? 05/09/2022

Yes, ADCY6 is involved in insulin secretion by pancreatic beta cells. It regulates the cAMP signaling pathway in beta cells, which plays a critical role in insulin secretion. Mutation of ADCY6 has been associated with impaired insulin secretion and glucose metabolism, suggesting that it may be a potential therapeutic target for diabetes.

What approaches could be used to develop drugs that target ADCY6? 06/09/2021

Several approaches could be used to develop drugs that target ADCY6. One approach is to identify small molecules that bind to and activate or inhibit ADCY6. Another approach is to develop antibodies or other protein-based therapeutics that target ADCY6. Finally, gene therapy approaches could be used to modulate ADCY6 expression or activity in specific tissues.

Can ADCY6 be a potential target for the treatment of anxiety and depression? 05/13/2020

ADCY6 has been implicated in the regulation of anxiety and depression-related behavior in animal models. Inhibition of ADCY6 has been shown to reduce anxiety and depressive behaviors in mice. Therefore, ADCY6 could be a potential therapeutic target for the treatment of anxiety and depression.

How is ADCY6 function studied in cells and organisms? 01/27/2020

ADCY6 function can be studied in cells and organisms using a variety of techniques, including genetic manipulation, pharmacological inhibition, and biochemical assays. Genetic manipulation can involve the use of gene knockout or knockdown techniques to evaluate the effects of ADCY6 on cellular or organismal functions. Pharmacological inhibition can involve the use of specific inhibitors to block ADCY6 activity and assess its role in various physiological processes. Biochemical assays can be used to measure the activity and cAMP production of ADCY6 in response to different stimuli.

What are the potential clinical implications of targeting ADCY6? 07/24/2019

Targeting ADCY6 may have clinical implications for the treatment of various diseases. For example, drugs that target ADCY6 may have therapeutic benefits in the treatment of heart failure, hypertension, diabetes, and neurological disorders, among others. However, more research is needed to fully understand the potential clinical applications of targeting ADCY6.

Are there any drugs currently available that target ADCY6? 07/12/2019

There are no drugs currently available that specifically target ADCY6. However, several drugs that modulate cAMP levels, such as fosfomycin and cilostamide, indirectly affect ADCY6 activity.

Can ADCY6 be used as a diagnostic biomarker for heart disease? 05/26/2019

ADCY6 gene mutations have been associated with various forms of heart disease, and some studies suggest that genetic testing for ADCY6 mutations may be a useful diagnostic tool for identifying individuals at risk for heart disease. However, more research is needed to determine the extent to which ADCY6 can be used as a reliable biomarker for heart disease.

How could targeting ADCY6 be used in the treatment of cardiovascular disease? 08/16/2018

ADCY6 plays an important role in regulating cardiac function, and drugs that target ADCY6 could potentially be used to treat various types of cardiovascular disease. For example, drugs that activate ADCY6 may be useful in the treatment of heart failure, while drugs that inhibit ADCY6 may be useful in the treatment of arrhythmias.

How is ADCY6 expression regulated? 07/04/2018

ADCY6 expression can be regulated at the transcriptional, post-transcriptional, and post-translational levels. Transcription of ADCY6 is regulated by various transcription factors, such as CREB and NF-κB, which bind to the promoter region of the gene. Post-transcriptional regulation can occur through alternative splicing or modulation of mRNA stability. Post-translational regulation can occur through phosphorylation, acetylation, and other modifications that affect the activity and stability of the protein.

How is ADCY6 regulated? 09/24/2017

ADCY6 activity is regulated by a variety of signaling pathways. For example, it can be activated by G-protein-coupled receptors, which bind to the enzyme and stimulate its activity. ADCY6 can also be regulated by calcium, which binds to calmodulin and activates the enzyme. Additionally, various kinases and phosphatases can modulate the activity of ADCY6.

What are some potential therapeutic applications for targeting ADCY6? 02/14/2017

ADCY6 has been implicated in a variety of physiological processes, including cardiac function, blood pressure regulation, and glucose metabolism. As a result, drugs that target ADCY6 may have therapeutic benefits in the treatment of cardiovascular disease, hypertension, and type 2 diabetes, among other conditions.

What challenges need to be overcome in order to develop drugs that target ADCY6? 12/14/2015

One major challenge in developing drugs that target ADCY6 is the need to selectively target the enzyme without affecting other isoforms of ADCY or other components of the cAMP signaling pathway. Another challenge is to develop drugs that can effectively penetrate the cell membrane and reach the target tissue in sufficient concentrations. Finally, toxicity and off-target effects must be carefully evaluated to ensure safety and efficacy of any potential drugs.

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