• Official Full Name

    aldo-keto reductase family 1, member B3 (aldose reductase)

  • Synonyms

    AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b1; Aldor1; aldose reductase; aldehyde reductase 1; aldo-keto reductase family 1, member B1 (aldose reductase);
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Mouse
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • His (Fc)
    • Avi
    • MYC
    • DDK
    Species Cat.# Product name Source (Host) Tag Price
    Mouse AKR1B3-1492M Recombinant Mouse AKR1B3 Protein Mammalian Cell His
    Mouse Akr1b3-3268M Recombinant Mouse Akr1b3, His-tagged E.Coli or Yeast His
    Mouse Akr1b3-576M Recombinant Mouse Akr1b3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse AKR1B3-435M Recombinant Mouse AKR1B3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Akr1b3-7161M Recombinant Mouse Akr1b3 Protein, His-tagged E.coli His
    Mouse AKR1B3-435M-B Recombinant Mouse AKR1B3 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    Akr1b3 involved in several pathways and played different roles in them. We selected most pathways Akr1b3 participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Akr1b3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversionsGKUP;UGP2;SORD;GUSB;UGT1A7C;RPE;KL;UGT2B7;DHDH
    Fructose and mannose metabolismPFKL;AKR1B1L;AKR1B7;SORD;PFKFB4;KHK;ALDOCA;TPI1B;C12orf5
    Galactose metabolismPFKP;G6PC3;GALT;PFKL;AKR1B7;AKR1B1;AKR1B1L;PGM2;HKDC1
    Glycerolipid metabolismAGPAT1;DGKZ;ALDH3A2A;ALDH7A1;MOGAT3A;glpK;LYCAT;DGKA;AKR1A1

    Akr1b3 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, glyceraldehyde oxidoreductase activity, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Akr1b3 itself. We selected most functions Akr1b3 had, and list some proteins which have the same functions with Akr1b3. You can find most of the proteins on our site.

    Function Related Protein
    alditol:NADP+ 1-oxidoreductase activityAKR1C3;AKR1C2;AKR1C21;AKR1B7;PRKRA;AKR7A2;Akr1b3;AKR1B8;ADH4
    glyceraldehyde oxidoreductase activityAKR1B1;Akr1b3
    oxidoreductase activityMOSC2;ETFDH;CYP2P9;OSGIN2;GPX1A;CYP2B19;GULO;GSTO2;PDPR

    Akr1b3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Akr1b3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Akr1b3.

    Got1; Prkce; Ywhae; Ywhaz; Pgls; Nphp1

    • Q&As
    • Reviews

    Q&As (13)

    Ask a question
    What factors affect the expression level of AKR1B3 protein in human body? 04/26/2023

    The expression of AKR1B3 protein in human body is influenced by many factors, including genetic factors, environmental factors, and drug effects.

    What diseases is Akr1b3 associated with? 04/10/2023

    Akr1b3 protein is often associated with metabolic diseases such as diabetes, metabolic syndrome, nonalcoholic fatty liver disease, and is also associated with cancer and neurodegenerative diseases.

    In what diseases do Akr1b3 inhibitors have potential applications? 04/09/2023

    Akr1b3 inhibitors can be used in the treatment of metabolic diseases such as diabetes and non-alcoholic fatty liver disease, and also have certain therapeutic effects on tumors.

    Whether the association of Akr1b3 protein with diabetes is related to disease progression? 12/22/2022

    Akr1b3 protein can affect the normal function of insulin signaling pathway, thus affecting glucose metabolism and insulin action, which is related to the occurrence and development of diabetes.

    What function does the Akr1b3 protein perform in the human body 08/28/2022

    Akr1b3 protein is mainly involved in the metabolism of polysaccharides, polyphenols, steroids, steroids and other substances, but also involved in antioxidant and cell proliferation regulation.

    Which type of cancer is Akr1b3 more promising? 08/17/2022

    Akr1b3 protein has potential application prospects in the treatment of prostate cancer, ovarian cancer and other monotherapy and combination chemotherapy.

    Which cell signaling pathways is Akr1b3 involved in? 02/02/2022

    Akr1b3 is involved in a variety of signaling pathways, such as AMPK, NF-κB, P53, AKT and other signaling pathways, and has various biological functions and regulatory effects.

    How does Akr1b3 play a role in neurodegenerative diseases? 11/20/2021

    Akr1b3 protein is involved in the development of neurodegenerative diseases such as Parkinson's disease through the regulation of signaling pathways such as oxidative stress, neuronal apoptosis, and NF-κB.

    Which diseases are associated with Akr1b3 mutation? 09/18/2021

    The mutation of Akr1b3 gene is associated with genetic diseases such as congenital myasthenia and muscular dystrophy.

    Is there a correlation between Akr1b3 protein and lung disease? 05/22/2021

    A study published in the International Journal of Chronic Obstructive Pulmonary Disease in 2018 investigated the role of Akr1b3 in the pathogenesis of COPD and found that it was upregulated in lung tissues of patients with COPD. The authors suggested that Akr1b3 may contribute to the development of airway inflammation, mucus hypersecretion, and airway remodeling, which are characteristic features of COPD.Another study published in the Journal of Cellular Physiology in 2019 showed that Akr1b3 was involved in the regulation of pulmonary fibrosis, a common lung disease characterized by the formation of scar tissue in the lungs. The authors found that Akr1b3 promoted the proliferation and migration of lung fibroblasts, which are key players in the development of pulmonary fibrosis.

    What about Akr1b3 protein? 11/11/2020

    Akr1b3 protein is an aldose reductase that is associated with a variety of metabolism and diseases and is widely distributed in various tissues of the human body.

    What are the methods for laboratory detection of Akr1b3 protein? 08/02/2020

    Akr1b3 protein is mainly detected by enzyme-linked immunosorbent assay, Western blotting and immunohistochemistry in laboratory.

    Does Akr1b3 have an effect on tumors? 08/06/2019

    The expression level of Akr1b3 protein in tumor cells is increased, and it is involved in many aspects of tumor growth, proliferation, invasion and metastasis, and has become a new tumor therapeutic target.

    Customer Reviews (4)

    Write a review

      Activity is specific. -


        Easy to purify in production, high purity. -


          Compared with other methods, qPCR detection is better. -


            Strong operability in the experiment. -

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