Akr1b3
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Official Full Name
aldo-keto reductase family 1, member B3 (aldose reductase)
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Synonyms
AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b1; Aldor1; aldose reductase; aldehyde reductase 1; aldo-keto reductase family 1, member B1 (aldose reductase);
Species | Cat.# | Product name | Source (Host) | Tag | Price |
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Mouse | AKR1B3-1492M | Recombinant Mouse AKR1B3 Protein | Mammalian Cell | His |
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Mouse | Akr1b3-3268M | Recombinant Mouse Akr1b3, His-tagged | E.Coli or Yeast | His |
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Mouse | Akr1b3-576M | Recombinant Mouse Akr1b3 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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Mouse | AKR1B3-435M | Recombinant Mouse AKR1B3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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Mouse | Akr1b3-7161M | Recombinant Mouse Akr1b3 Protein, His-tagged | E.coli | His |
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Mouse | AKR1B3-435M-B | Recombinant Mouse AKR1B3 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
Akr1b3 involved in several pathways and played different roles in them. We selected most pathways Akr1b3 participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Akr1b3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pentose and glucuronate interconversions | GKUP;UGP2;SORD;GUSB;UGT1A7C;RPE;KL;UGT2B7;DHDH |
Fructose and mannose metabolism | PFKL;AKR1B1L;AKR1B7;SORD;PFKFB4;KHK;ALDOCA;TPI1B;C12orf5 |
Galactose metabolism | PFKP;G6PC3;GALT;PFKL;AKR1B7;AKR1B1;AKR1B1L;PGM2;HKDC1 |
Glycerolipid metabolism | AGPAT1;DGKZ;ALDH3A2A;ALDH7A1;MOGAT3A;glpK;LYCAT;DGKA;AKR1A1 |
Metabolic pathways | PMM1;SC5DL;DGAT1A;DGAT1;ATP6V1G2;REV3L;MLYCD;ALDH2;MTHFR |
Akr1b3 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, glyceraldehyde oxidoreductase activity, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Akr1b3 itself. We selected most functions Akr1b3 had, and list some proteins which have the same functions with Akr1b3. You can find most of the proteins on our site.
Function | Related Protein |
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alditol:NADP+ 1-oxidoreductase activity | AKR1C3;AKR1C2;AKR1C21;AKR1B7;PRKRA;AKR7A2;Akr1b3;AKR1B8;ADH4 |
glyceraldehyde oxidoreductase activity | AKR1B1;Akr1b3 |
oxidoreductase activity | MOSC2;ETFDH;CYP2P9;OSGIN2;GPX1A;CYP2B19;GULO;GSTO2;PDPR |
Akr1b3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Akr1b3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Akr1b3.
Got1; Prkce; Ywhae; Ywhaz; Pgls; Nphp1
- Q&As
- Reviews
Q&As (13)
Ask a questionThe expression of AKR1B3 protein in human body is influenced by many factors, including genetic factors, environmental factors, and drug effects.
Akr1b3 protein is often associated with metabolic diseases such as diabetes, metabolic syndrome, nonalcoholic fatty liver disease, and is also associated with cancer and neurodegenerative diseases.
Akr1b3 inhibitors can be used in the treatment of metabolic diseases such as diabetes and non-alcoholic fatty liver disease, and also have certain therapeutic effects on tumors.
Akr1b3 protein can affect the normal function of insulin signaling pathway, thus affecting glucose metabolism and insulin action, which is related to the occurrence and development of diabetes.
Akr1b3 protein is mainly involved in the metabolism of polysaccharides, polyphenols, steroids, steroids and other substances, but also involved in antioxidant and cell proliferation regulation.
Akr1b3 protein has potential application prospects in the treatment of prostate cancer, ovarian cancer and other monotherapy and combination chemotherapy.
Akr1b3 is involved in a variety of signaling pathways, such as AMPK, NF-κB, P53, AKT and other signaling pathways, and has various biological functions and regulatory effects.
Akr1b3 protein is involved in the development of neurodegenerative diseases such as Parkinson's disease through the regulation of signaling pathways such as oxidative stress, neuronal apoptosis, and NF-κB.
The mutation of Akr1b3 gene is associated with genetic diseases such as congenital myasthenia and muscular dystrophy.
A study published in the International Journal of Chronic Obstructive Pulmonary Disease in 2018 investigated the role of Akr1b3 in the pathogenesis of COPD and found that it was upregulated in lung tissues of patients with COPD. The authors suggested that Akr1b3 may contribute to the development of airway inflammation, mucus hypersecretion, and airway remodeling, which are characteristic features of COPD.Another study published in the Journal of Cellular Physiology in 2019 showed that Akr1b3 was involved in the regulation of pulmonary fibrosis, a common lung disease characterized by the formation of scar tissue in the lungs. The authors found that Akr1b3 promoted the proliferation and migration of lung fibroblasts, which are key players in the development of pulmonary fibrosis.
Akr1b3 protein is an aldose reductase that is associated with a variety of metabolism and diseases and is widely distributed in various tissues of the human body.
Akr1b3 protein is mainly detected by enzyme-linked immunosorbent assay, Western blotting and immunohistochemistry in laboratory.
The expression level of Akr1b3 protein in tumor cells is increased, and it is involved in many aspects of tumor growth, proliferation, invasion and metastasis, and has become a new tumor therapeutic target.
Customer Reviews (4)
Write a reviewActivity is specific. -
Easy to purify in production, high purity. -
Compared with other methods, qPCR detection is better. -
Strong operability in the experiment. -
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