Recombinant Mouse Akr1b3 Protein, MYC/DDK-tagged

• Cat.No.: Akr1b3-576M
• Product Overview: Purified recombinant protein of full-length mouse aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 35.7 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) [ Mus musculus (house mouse) ]
• Official Symbol: Akr1b3
• Synonyms: Akr1b3; aldo-keto reductase family 1, member B3 (aldose reductase); AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b1; Aldor1; aldo-keto reductase family 1 member B1; aldehyde reductase 1; aldo-keto reductase family 1 member B3; aldo-keto reductase family 1, member B1 (aldose reductase); aldose reductase; EC 1.1.1.21; EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54
• Gene ID: 11677
• mRNA Refseq: NM_009658
• Protein Refseq: NP_033788
• UniProt ID: P45376

Reviews

03/15/2023

Akr1b3 have been widely recognized and used in research in related fields.

04/30/2022

Experimental results using Akr1b3 are accurate and reliable, and the data are highly scientific.

05/30/2021

Akr1b3 production process is stable and reliable, with high batch repeatability.

05/16/2021

The protein performed the expected biological effects in the experiment.

Q&As

What factors affect the expression level of AKR1B3 protein in human body?

The expression of AKR1B3 protein in human body is influenced by many factors, including genetic factors, environmental factors, and drug effects.

What diseases is Akr1b3 associated with?

Akr1b3 protein is often associated with metabolic diseases such as diabetes, metabolic syndrome, nonalcoholic fatty liver disease, and is also associated with cancer and neurodegenerative diseases.

In what diseases do Akr1b3 inhibitors have potential applications?

Akr1b3 inhibitors can be used in the treatment of metabolic diseases such as diabetes and non-alcoholic fatty liver disease, and also have certain therapeutic effects on tumors.

Whether the association of Akr1b3 protein with diabetes is related to disease progression?

Akr1b3 protein can affect the normal function of insulin signaling pathway, thus affecting glucose metabolism and insulin action, which is related to the occurrence and development of diabetes.

What function does the Akr1b3 protein perform in the human body

Akr1b3 protein is mainly involved in the metabolism of polysaccharides, polyphenols, steroids, steroids and other substances, but also involved in antioxidant and cell proliferation regulation.

Which type of cancer is Akr1b3 more promising?

Akr1b3 protein has potential application prospects in the treatment of prostate cancer, ovarian cancer and other monotherapy and combination chemotherapy.

Which cell signaling pathways is Akr1b3 involved in?

Akr1b3 is involved in a variety of signaling pathways, such as AMPK, NF-κB, P53, AKT and other signaling pathways, and has various biological functions and regulatory effects.

How does Akr1b3 play a role in neurodegenerative diseases?

Akr1b3 protein is involved in the development of neurodegenerative diseases such as Parkinson's disease through the regulation of signaling pathways such as oxidative stress, neuronal apoptosis, and NF-κB.

Which diseases are associated with Akr1b3 mutation?

The mutation of Akr1b3 gene is associated with genetic diseases such as congenital myasthenia and muscular dystrophy.

Is there a correlation between Akr1b3 protein and lung disease?

A study published in the International Journal of Chronic Obstructive Pulmonary Disease in 2018 investigated the role of Akr1b3 in the pathogenesis of COPD and found that it was upregulated in lung tissues of patients with COPD. The authors suggested that Akr1b3 may contribute to the development of airway inflammation, mucus hypersecretion, and airway remodeling, which are characteristic features of COPD.Another study published in the Journal of Cellular Physiology in 2019 showed that Akr1b3 was involved in the regulation of pulmonary fibrosis, a common lung disease characterized by the formation of scar tissue in the lungs. The authors found that Akr1b3 promoted the proliferation and migration of lung fibroblasts, which are key players in the development of pulmonary fibrosis.

What about Akr1b3 protein?

Akr1b3 protein is an aldose reductase that is associated with a variety of metabolism and diseases and is widely distributed in various tissues of the human body.

What are the methods for laboratory detection of Akr1b3 protein?

Akr1b3 protein is mainly detected by enzyme-linked immunosorbent assay, Western blotting and immunohistochemistry in laboratory.

Does Akr1b3 have an effect on tumors?

The expression level of Akr1b3 protein in tumor cells is increased, and it is involved in many aspects of tumor growth, proliferation, invasion and metastasis, and has become a new tumor therapeutic target.