AKR1C2

  • Official Full Name

    Aldo-keto reductase family 1 member C2

  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
  • Synonyms

    AKR1C2; AKR1C1; Aldo-keto reductase family 1 member C2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • DYKDDDDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKR1C2-456H Recombinant Human AKR1C2, His tagged E.coli His
Human AKR1C2-858H Recombinant Human AKR1C2 Protein, His-tagged E.coli His
Human AKR1C2-412H Recombinant Human AKR1C2 Protein, GST-tagged Wheat Germ GST
Human AKR1C2-18H Recombinant Human AKR1C2, MYC/DDK-tagged HEK293 Myc/DDK
Human AKR1C2-8930HCL Recombinant Human AKR1C2 293 Cell Lysate HEK293 N/A
Human AKR1C2-27158TH Recombinant Human AKR1C2 Wheat Germ N/A
Human AKR1C2-977H Recombinant Human AKR1C2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKR1C2-2895HFL Recombinant Full Length Human AKR1C2, Flag-tagged Mamanlian cells Flag
Human AKR1C2-898H Recombinant Human AKR1C2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKR1C2-27159TH Recombinant Human AKR1C2 Wheat Germ N/A
Human AKR1C2-16HF Recombinant Full Length Human AKR1C2 Protein In Vitro Cell Free System
Human AKR1C2-01H Recombinant Human AKR1C2 Protein, DYKDDDDK-tagged Human Cell DYKDDDDK
Human AKR1C2-1367HF Recombinant Full Length Human AKR1C2 Protein, GST-tagged In Vitro Cell Free System GST
Human AKR1C2-2502H Recombinant Human AKR1C2 protein, His-SUMO-tagged E.coli His-SUMO
Human AKR1C2-0452H Recombinant Human AKR1C2 Protein (Met1-Tyr323 ), Tag Free E.coli Tag Free
Rat AKR1C2-599R Recombinant Rat AKR1C2 Protein Mammalian Cell His
Rat AKR1C2-255R-B Recombinant Rat AKR1C2 Protein Pre-coupled Magnetic Beads HEK293
Rat AKR1C2-255R Recombinant Rat AKR1C2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKR1C2 involved in several pathways and played different roles in them. We selected most pathways AKR1C2 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Benzo(a)pyrene metabolismFAM84B;AKR1C4;AKR1A1;AKR1C2;CYP1B1;CYP3A4;CYP1A1
Bile acid and bile salt metabolismCYP7A1;ACOT8;CYP8B2;AKR1C21;SLC27A2A;AKR1C2;CYP27A1;SCP2B;AKR1C4
Chemical carcinogenesisCHRNA7;GSTP2;CYP3A25;CYP3A7;UGT1A7;CYP3A5;GSTM1;CYP2C18;CYP3A41B
MetabolismGDF1;SLC4A1B;NDUFAF4;CYP2AD3;AKAP5;PMVK;NFYAL;COX14;CYP3C4
Metabolism of lipids and lipoproteinsMED8;ACOT12;ACOT9;COQ7;SLC27A2;PTGR1;NEU3;DECR1;MED19
Metabolism of xenobiotics by cytochrome P450ADH2-1;GSTK1;AKR1C2;CYP2S1;PRKRA;AKR1C4;CYP2F1;ADH2-2
Steroid hormone biosynthesisCOMTB;CYP2C37;HSD17B12;CYP3A25;UGT1A2;UGT1A6;HSD17B6;UGT2A1;CYP3A7-CYP3AP1
Synthesis of bile acids and bile saltsAKR1C2;SLC27A2A;BRSK2;SCP2B

AKR1C2 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, bile acid binding, carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C2 itself. We selected most functions AKR1C2 had, and list some proteins which have the same functions with AKR1C2. You can find most of the proteins on our site.

Function Related Protein
alditol:NADP+ 1-oxidoreductase activityAKR1A1;AKR7A5;AKR1C21;AKR1B7;AKR1B8;AKR1C3;PRKRA;AKR7A2;Akr1b3
bile acid bindingSTARD5;FABP1;NR1H4;AKR1C2;PYGL;FABP10A;FABP6;PLA2G1B;AKR1C21
carboxylic acid bindingGOT1;PCK1;HIF1AN;HMGCL;AKR1C2;AKR1C21;GRHPR
ketosteroid monooxygenase activityAKR1C21;AKR1C3;AKR1C2
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorAKR1C6;AKR1C3;AKR1C4;NDUFS7;AKR1C2;AKR1C21;DHRS4;CBR1;DCXR
phenanthrene 9,10-monooxygenase activityMICAL2B;AKR1C2;AKR1C3;MICAL2;AKR1C21
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityDHDH;AKR1C2;AKR1C3;AKR1C21

AKR1C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C2.

LAMTOR5

  • Q&As
  • Reviews

Q&As (23)

Ask a question
Are there any inhibitors or activators of AKR1C2? 03/23/2023

Several compounds have been identified as inhibitors or activators of AKR1C2. For example, non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin can inhibit AKR1C2 activity, while certain steroid analogs can activate or inhibit the enzyme.

Are there any ongoing clinical trials targeting AKR1C2? 03/10/2023

As of now, there are no registered clinical trials specifically targeting AKR1C2. However, preclinical studies and in vitro experiments are exploring the potential of AKR1C2 as a therapeutic target. It is important to keep an eye on the latest research developments and clinical trial databases for updates on AKR1C2-targeted interventions.

Is AKR1C2 involved in any other biological processes besides metabolism? 02/13/2023

While AKR1C2 is primarily known for its metabolic roles, emerging research suggests it may have additional functions. Some studies suggest potential involvement of AKR1C2 in cell proliferation, differentiation, and apoptosis, indicating a broader role in cellular processes beyond its enzymatic activity. Further investigation is necessary to fully understand its non-metabolic functions.

Where is AKR1C2 found? 04/18/2022

AKR1C2 is found in various tissues throughout the body, including the liver, adrenal gland, and placenta. It is also present in certain cancer cell lines, where it may contribute to tumor progression and drug resistance.

Is AKR1C2 involved in drug metabolism? 04/16/2022

Yes, AKR1C2 is involved in the metabolism of various drugs and xenobiotics. It functions as a detoxification enzyme, converting reactive carbonyl compounds into less toxic and more water-soluble alcohols. AKR1C2's activity can influence drug efficacy and toxicity, and variations in its expression may affect individual responses to certain medications.

Can AKR1C2 polymorphisms affect its function? 02/16/2022

Polymorphisms, or variations, in the AKR1C2 gene can influence its function and enzymatic activity. Some polymorphisms have been associated with altered substrate preferences and catalytic efficiencies, potentially affecting steroid hormone metabolism. These genetic variations may contribute to interindividual differences in hormone-related phenotypes and disease susceptibilities.

What are the physiological roles of AKR1C2? 01/05/2022

AKR1C2 plays crucial roles in steroid hormone metabolism, regulating their bioavailability and activity. It also participates in the detoxification of harmful compounds and the regulation of prostaglandin levels, thereby influencing inflammatory and reproductive processes.

Are there any genetic variations in AKR1C2? 09/29/2021

Yes, genetic variations in AKR1C2 have been identified. Some polymorphisms in the AKR1C2 gene have been associated with altered enzyme activity and metabolic profiles, potentially affecting susceptibility to certain diseases and drug responses.

Does AKR1C2 have a role in drug resistance? 03/06/2021

AKR1C2 has been implicated in drug resistance, particularly in hormone-dependent cancers. Its upregulation in response to therapy can lead to the inactivation of drugs or the conversion of inactive hormones into their active forms, promoting tumor growth and reducing treatment effectiveness. Inhibiting or downregulating AKR1C2 expression may help overcome drug resistance in these contexts.

What substrates does AKR1C2 act upon? 02/09/2021

AKR1C2 acts upon a wide range of substrates, including steroid hormones such as testosterone and progesterone, prostaglandins, and other endogenous and exogenous compounds.

Can AKR1C2 be targeted for therapeutic interventions? 05/29/2020

Yes, AKR1C2 is considered a potential target for therapeutic interventions, particularly in cancer treatment. Inhibiting AKR1C2 activity may help overcome drug resistance and reduce tumor growth in hormone-dependent cancers. Additionally, targeting AKR1C2's involvement in prostaglandin metabolism may have implications in inflammatory disorders.

Can AKR1C2 be used as a diagnostic marker for any diseases? 04/18/2020

AKR1C2 has been investigated as a potential diagnostic marker for certain diseases, particularly hormone-dependent cancers. Its overexpression in tumors might serve as an indicator of disease progression and response to hormone-based therapies. However, further research is needed to establish its diagnostic utility.

What are the potential implications of AKR1C2 inhibition in cancer treatment? 07/24/2019

Inhibiting AKR1C2 in hormone-dependent cancers may have several implications. It can potentially increase the efficacy of hormone-based therapies by preventing the conversion of inactive hormones back into their active forms, thus reducing tumor growth. AKR1C2 inhibition may also help overcome drug resistance, as some cancer cell lines have been shown to upregulate AKR1C2 expression as a mechanism of resistance.

What are the different isoforms of AKR1C2? 03/02/2019

AKR1C2 is a member of the AKR1C subfamily, which includes three isoforms: AKR1C1, AKR1C2, and AKR1C3. These isoforms share a high degree of sequence homology and exhibit similar catalytic activities. However, they may have differential expression patterns and substrate preferences in specific tissues or cell types.

Can AKR1C2 be targeted for the development of novel therapeutics? 12/29/2018

AKR1C2 has attracted attention as a potential target for drug development, particularly in the field of cancer treatment. Inhibiting AKR1C2 activity may enhance the effectiveness of hormone-based therapies and help overcome drug resistance in hormone-dependent cancers, such as prostate and breast cancer. Furthermore, the modulation of AKR1C2's involvement in other biological processes may hold therapeutic potential for a range of disorders.

Are there any known mutations or dysregulation of the AKR1C2 gene in diseases? 11/12/2018

Some studies have reported genetic alterations and dysregulation of the AKR1C2 gene in certain diseases. For example, alterations in the AKR1C2 gene have been linked to the development of endometriosis and ovarian cancer. However, the full extent of AKR1C2 gene abnormalities in diseases is still under investigation.

Is AKR1C2 associated with any endocrine disorders? 09/20/2018

AKR1C2 dysregulation has been linked to various endocrine disorders. For example, it has been implicated in polycystic ovary syndrome (PCOS), a common endocrine disorder characterized by hormonal imbalances. Increased AKR1C2 expression and aberrant steroid metabolism in PCOS patients have been reported. However, further research is necessary to fully understand the exact mechanisms and implications of AKR1C2 in endocrine disorders.

What implications does AKR1C2 have in cancer? 05/15/2018

AKR1C2 has been implicated in cancer progression and drug resistance. Its overexpression has been observed in various cancers, including breast, prostate, and lung cancers, and it may contribute to the development of hormone-dependent tumors and resistance to chemotherapy drugs.

Are there any known drug-drug interactions involving AKR1C2? 01/28/2018

The involvement of AKR1C2 in drug metabolism suggests the potential for drug-drug interactions. However, specific drug interactions mediated by AKR1C2 have not been extensively studied or documented. Further research is needed to determine the extent of AKR1C2's impact on drug interactions.

Is AKR1C2 a target for drug development? 10/22/2017

Yes, AKR1C2 has drawn interest as a potential drug target due to its involvement in cancer and drug metabolism. Inhibitors of AKR1C2 are being explored as potential anticancer agents, particularly for tumors that rely on hormone signaling pathways.

What are the structural characteristics of AKR1C2 protein? 11/01/2016

AKR1C2 belongs to the AKR superfamily, characterized by a conserved Rossmann fold domain. It has a molecular weight of approximately 37 kDa and consists of 323 amino acids. AKR1C2 contains a coenzyme-binding site and catalytic residues essential for its reductase activity.

How is AKR1C2 regulated in the body? 09/08/2016

The regulation of AKR1C2 expression can be influenced by various factors, including hormonal signals, transcriptional regulators, epigenetic modifications, and post-translational modifications. For example, AKR1C2 expression is induced by androgens and glucocorticoids and can be suppressed by estrogen signaling. Transcription factors like AR (androgen receptor) and GR (glucocorticoid receptor) bind to specific regulatory regions of the AKR1C2 gene, modulating its expression.

Does AKR1C2 have any association with neurological disorders? 06/08/2016

AKR1C2's expression has been detected in the brain, and studies suggest its involvement in neurosteroid metabolism. However, the precise role of AKR1C2 in neurological disorders is not yet well understood. It has been implicated in conditions such as Alzheimer's disease and Parkinson's disease, but more research is needed to establish its significance in these disorders.

Customer Reviews (4)

Write a review
Reviews
03/16/2023

    Their dedicated team of experts is prompt, knowledgeable, and readily available to tackle any hurdles or concerns I may encounter.

    11/19/2021

      By harnessing the power of the AKR1C2 protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.

      12/26/2019

        Used in protein electron microscopy structure analysis.Great.

        09/21/2017

          The AKR1C2 protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.

          Ask a Question for All AKR1C2 Products

          Required fields are marked with *

          My Review for All AKR1C2 Products

          Required fields are marked with *

          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends