AKR1C2 Protein


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Official Full Name Aldo-keto reductase family 1 member C2
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms AKR1C2; AKR1C1; Aldo-keto reductase family 1 member C2
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1C2-01H Recombinant Human AKR1C2 Protein, DYKDDDDK-tagged Human Cell DYKDDDDK
    Human AKR1C2-2502H Recombinant Human AKR1C2 protein, His-SUMO-tagged E.coli His-SUMO
    Human AKR1C2-18H Recombinant Human AKR1C2, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKR1C2-27158TH Recombinant Human AKR1C2 Wheat Germ N/A
    Human AKR1C2-27159TH Recombinant Human AKR1C2 Wheat Germ N/A
    Human AKR1C2-412H Recombinant Human AKR1C2 Protein, GST-tagged Wheat Germ GST
    Human AKR1C2-456H Recombinant Human AKR1C2, His tagged E.coli His
    Human AKR1C2-858H Recombinant Human AKR1C2 Protein, His-tagged E.coli His
    Human AKR1C2-8930HCL Recombinant Human AKR1C2 293 Cell Lysate HEK293 N/A
    Human AKR1C2-898H Recombinant Human AKR1C2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AKR1C2-977H Recombinant Human AKR1C2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Rat AKR1C2-599R Recombinant Rat AKR1C2 Protein Mammalian Cell His

    AKR1C2 involved in several pathways and played different roles in them. We selected most pathways AKR1C2 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Benzo(a)pyrene metabolism CYP1B1; FAM84B; CYP1A1; CYP3A4; AKR1C2; AKR1C4; AKR1A1
    Bile acid and bile salt metabolism AKR1C2; SLC27A2; Alb; SLCO1B1; CYP7A1; SCP2B; BRSK2; NCOA2; SLC27A2A; SLC27A5
    Chemical carcinogenesis SULT1A2; GSTA1; CYP2C38; GSTT1; UGT1A3; UGT1A6B; FAM84B; CBR1; GSTM4; CYP1A1
    Metabolism GYG1A; UGT1B3; ADHFE1; APOA4B.2; CYP2F1; CYB5R3; ETFA; COL4A3BP; PDK4; CPNE6
    Metabolism of lipids and lipoproteins CYP2AD2; MED8; CSNK1G2; GDF1; ARSJ; CDK19; LBR; TPTE; FAAH2A; MED29
    Metabolism of xenobiotics by cytochrome P450 ADH2-2; AKR1C4; PRKRA; ADH2-1; GSTK1; CYP2S1; CYP2F1; AKR1C2
    Steroid hormone biosynthesis HSD3B5; HSD17B12; UGT1A6; CYP2D9; HSD17B2; SULT2ST3; CYP2C37; UGT2A2; CYP1A; HSD11B2
    Synthesis of bile acids and bile salts SLC27A2A; SCP2B; AKR1C2; BRSK2

    AKR1C2 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, bile acid binding, carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C2 itself. We selected most functions AKR1C2 had, and list some proteins which have the same functions with AKR1C2. You can find most of the proteins on our site.

    Function Related Protein
    alditol:NADP+ 1-oxidoreductase activity AKR7A2; AKR1A1; Akr1b3; AKR1C3; AKR1B1; AKR7A5; PRKRA; ADH4; AKR1C2; AKR1B8
    bile acid binding AKR1C2; FABP1; AKR1C21; PLA2G1B; PYGL; FABP6; FABP10A; STARD5; NR1H4
    carboxylic acid binding HIF1AN; HMGCL; GRHPR; PCK1; AKR1C21; AKR1C2; GOT1
    ketosteroid monooxygenase activity AKR1C3; AKR1C2; AKR1C21
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor AKR1C3; AKR1C2; AKR1C4; AKR1C21; CBR1; NDUFS7; AKR1C6; DHRS4; DCXR
    phenanthrene 9,10-monooxygenase activity AKR1C21; AKR1C2; MICAL2; MICAL2B; AKR1C3
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity AKR1C21; AKR1C2; AKR1C3; DHDH

    AKR1C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C2.


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