AKR1C2 Protein


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Official Full Name Aldo-keto reductase family 1 member C2
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms AKR1C2; AKR1C1; Aldo-keto reductase family 1 member C2
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • In Vitro Cell Free System
    • Mamanlian cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1C2-18H Recombinant Human AKR1C2, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human AKR1C2-412H Recombinant Human AKR1C2 Protein, GST-tagged Wheat Germ GST Inquiry
    Human AKR1C2-456H Recombinant Human AKR1C2, His tagged E.coli His Inquiry
    Human AKR1C2-858H Recombinant Human AKR1C2 Protein, His-tagged E.coli His Inquiry
    Rat AKR1C2-599R Recombinant Rat AKR1C2 Protein Mammalian Cell His Inquiry
    Human AKR1C2-8930HCL Recombinant Human AKR1C2 293 Cell Lysate HEK293 N/A Inquiry
    Human AKR1C2-01H Recombinant Human AKR1C2 Protein, DYKDDDDK-tagged Human Cell DYKDDDDK Inquiry
    Human AKR1C2-1367HF Recombinant Full Length Human AKR1C2 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human AKR1C2-16HF Recombinant Full Length Human AKR1C2 Protein In Vitro Cell Free System Inquiry
    Human AKR1C2-2502H Recombinant Human AKR1C2 protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Human AKR1C2-2895HFL Recombinant Full Length Human AKR1C2, Flag-tagged Mamanlian cells Flag Inquiry
    Human AKR1C2-27158TH Recombinant Human AKR1C2 Wheat Germ N/A Inquiry
    Human AKR1C2-27159TH Recombinant Human AKR1C2 Wheat Germ N/A Inquiry
    Human AKR1C2-898H Recombinant Human AKR1C2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human AKR1C2-977H Recombinant Human AKR1C2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry

    AKR1C2 involved in several pathways and played different roles in them. We selected most pathways AKR1C2 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Benzo(a)pyrene metabolism CYP1A1; AKR1A1; AKR1C4; AKR1C2; CYP3A4; CYP1B1; FAM84B
    Bile acid and bile salt metabolism SLC27A2; CYP8B2; BRSK2; CYP46A1; SLC27A5; SLC27A2A; AKR1C6; AKR1C21; AKR1C4; CYP7A1
    Chemical carcinogenesis CBR1; GSTM2; UGT2B15; CYP2C55; GSTT1; MGST1; CYP2C19; GSTA4; MGST2; CYP2C54
    Metabolism CYP26A1; CHKB; CHKA; GYG1A; CYP27A1; SUMF2; CYP4B1; STAB2; CYP8B2; SACM1LB
    Metabolism of lipids and lipoproteins APOA5; SGMS2; SIN3B; ESRRA; INSIG2; MED6; SUMF2; GLTPA; CDK19; ACOT9
    Metabolism of xenobiotics by cytochrome P450 ADH2-1; PRKRA; ADH2-2; AKR1C2; CYP2F1; AKR1C4; GSTK1; CYP2S1
    Steroid hormone biosynthesis SULT2ST3; CYP2C39; HSD3B6; UGT5G1; CYP19A1A; SULT1E1; CYP7A1A; HSD11B2; UGT2A1; UGT2A2
    Synthesis of bile acids and bile salts SLC27A2A; AKR1C2; SCP2B; BRSK2

    AKR1C2 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, bile acid binding, carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C2 itself. We selected most functions AKR1C2 had, and list some proteins which have the same functions with AKR1C2. You can find most of the proteins on our site.

    Function Related Protein
    alditol:NADP+ 1-oxidoreductase activity AKR1C21; AKR1B7; Akr1b3; AKR1B1; AKR7A2; PRKRA; AKR1C3; AKR1A1; AKR1C2; ADH4
    bile acid binding PLA2G1B; FABP10A; FABP1; STARD5; PYGL; FABP6; AKR1C2; AKR1C21; NR1H4
    carboxylic acid binding GRHPR; GOT1; AKR1C21; HIF1AN; PCK1; HMGCL; AKR1C2
    ketosteroid monooxygenase activity AKR1C2; AKR1C3; AKR1C21
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor DCXR; AKR1C21; CBR1; AKR1C2; DHRS4; NDUFS7; AKR1C6; AKR1C4; AKR1C3
    phenanthrene 9,10-monooxygenase activity MICAL2B; MICAL2; AKR1C2; AKR1C21; AKR1C3
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity AKR1C3; AKR1C21; DHDH; AKR1C2

    AKR1C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C2.


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