AKR1C2
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Official Full Name
Aldo-keto reductase family 1 member C2 -
Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. -
Synonyms
AKR1C2;AKR1C1;Aldo-keto reductase family 1 member C2
Recombinant Proteins
- Human
- Rat
- HEK293
- Wheat Germ
- E.coli
- Mammalian Cells
- Human Cells
- In Vitro Cell Free System
- DDK
- Myc
- GST
- His
- Non
- Flag
- SUMO
- Avi
- Fc
Involved Pathway
AKR1C2 involved in several pathways and played different roles in them. We selected most pathways AKR1C2 participated on our site, such as Benzo(a)pyrene metabolism,Bile acid and bile salt metabolism,Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile acid and bile salt metabolism | Alb,ACOT8,SLCO1B1,CYP46A1,AKR1C4,CYP8B2,NCOA2,SLC27A2,SLC27A5,AKR1C6 |
| Synthesis of bile acids and bile salts | SCP2B,SLC27A2A,BRSK2 |
| Metabolism of xenobiotics by cytochrome P450 | ADH2-2,PRKRA,CYP2F1,AKR1C4,ADH2-1,CYP2S1,GSTK1 |
| Steroid hormone biosynthesis | HSD17B12,HSD17B8,HSD17B1,UGT1A4,CYP19A1A,HSD3B2,UGT1A2,HSD17B12B,CYP3A25,CYP3A7-CYP3AP1 |
| Metabolism | ABHD3,COX6B1,CPNE1,APOC2,FAAH2,LYPLA1,CYP2B6,CERS3B,PDK2,HIBADH |
| Chemical carcinogenesis | CYP3A7,CYP2C70,UGT2A2,UGT1A6A,HSD11B1,ADH7,CYP2A6,CYP2C39,ARNT,NAT1 |
| Benzo(a)pyrene metabolism | AKR1C4,CYP1B1,CYP1A1,CYP3A4,FAM84B,AKR1A1 |
| Metabolism of lipids and lipoproteins | ARSD,ECI1,MED8,APOBB.1,CHAT,COQ6,MED31,ACOT11A,HSD17B11,PLD6 |
Protein Function
AKR1C2 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity,bile acid binding,carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C2 itself. We selected most functions AKR1C2 had, and list some proteins which have the same functions with AKR1C2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alditol:NADP+ 1-oxidoreductase activity | AKR7A5,AKR1B8,PRKRA,AKR1A1,Akr1b3,AKR1C3,AKR1C21,AKR1B1,AKR7A2,AKR1B7 |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | DHRS4,AKR1C6,AKR1C4,AKR1C3,DCXR,CBR1,AKR1C21,NDUFS7 |
| ketosteroid monooxygenase activity | AKR1C21,AKR1C3 |
| phenanthrene 9,10-monooxygenase activity | AKR1C3,MICAL2B,MICAL2,AKR1C21 |
| carboxylic acid binding | GOT1,PCK1,HIF1AN,AKR1C21,GRHPR,HMGCL |
| bile acid binding | PLA2G1B,FABP6,FABP10A,AKR1C21,NR1H4,PYGL,STARD5,FABP1 |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | DHDH,AKR1C3,AKR1C21 |
Interacting Protein
AKR1C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C2.
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