AKR1C4

  • Official Full Name

    aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
  • Synonyms

    AKR1C4; aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4); CHDR; aldo-keto reductase family 1 member C4; 3 alpha HSD; C11; CDR; DD4; HAKRA; MGC22581; 3-alpha-HSD1; di;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKR1C4-721H Active Recombinant Human AKR1C4 E.coli N/A
Human AKR1C4-1006H Active Recombinant Human AKR1C4 protein, His-tagged E.coli His
Human AKR1C4-414H Recombinant Human AKR1C4 Protein, GST-tagged Wheat Germ GST
Human AKR1C4-177H Recombinant Human AKR1C4 Protein, His-tagged E.coli His
Human AKR1C4-9534H Recombinant Human AKR1C4, GST-tagged E.coli GST 1-323a.a.
Human AKR1C4-218H Recombinant Human AKR1C4 protein, His-tagged E.coli His Met1-Tyr323
Human AKR1C4-29344TH Recombinant Human AKR1C4, His-tagged E.coli His 343 amino acids
Human AKR1C4-8929HCL Recombinant Human AKR1C4 293 Cell Lysate HEK293 N/A
Human AKR1C4-1269H Recombinant Human AKR1C4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKR1C4-1369HF Recombinant Full Length Human AKR1C4 Protein, GST-tagged In Vitro Cell Free System GST 323 amino acids
Human AKR1C4-0270H Recombinant Human AKR1C4 Protein (Met1-Tyr323), N-GST-tagged E.coli N-GST Met1-Tyr323
Rhesus Macaque AKR1C4-294R Recombinant Rhesus monkey AKR1C4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AKR1C4-122R Recombinant Rhesus Macaque AKR1C4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKR1C4-122R-B Recombinant Rhesus Macaque AKR1C4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKR1C4 involved in several pathways and played different roles in them. We selected most pathways AKR1C4 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Benzo(a)pyrene metabolismCYP3A4;AKR1C2;AKR1A1;AKR1C4;CYP1A1;CYP1B1;FAM84B
Bile acid and bile salt metabolismNCOA2;CYP7A1;CYP27A1;Alb;AKR1C2;CYP8B2;SCP2B;SLCO1B1;SLC27A2A
Metabolic pathwaysH6PD;RABGNT1;GMPPA;MECR;CYP19A1;AMPD3;CHSY3;PIGX;AMY1A
MetabolismISCUB;SLC5A2;ACSF3;DIO2;CEPT1A;CYP2B6;SYT5;PTGDSA;TIMMDC1
Metabolism of lipids and lipoproteinsMED21;ACOT12;APOA4A;FABP1B.1;CSNK1G2;GGTLC1;G0S2;CYP2Y3;DHCR7
Metabolism of xenobiotics by cytochrome P450GSTK1;CYP2F1;ADH2-2;CYP2S1;PRKRA;ADH2-1;AKR1C2;AKR1C4
Primary bile acid biosynthesisCH25H;BAAT;CYP8B1;ACOX2;CYP7A1A;HSD3B7;CH25HL1.2;AMACR;CYP7B1
Retinoid metabolism and transportAPOM;LRP10;CLPS;BCO2A;AKR1C6;AKR1C4;AKR1C21;LRP12;APOA4A

AKR1C4 has several biochemical functions, for example, aldo-keto reductase (NADP) activity, androsterone dehydrogenase activity, bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C4 itself. We selected most functions AKR1C4 had, and list some proteins which have the same functions with AKR1C4. You can find most of the proteins on our site.

Function Related Protein
aldo-keto reductase (NADP) activityAKR7A3;HSD11B1LA;HSD3B6;AKR1B1;AKR1B10;SPR;MIOX;AKR1C3;AKR1C21
androsterone dehydrogenase activityAKR1C4;AKR1C3;AKR1C21;AKR1C6
bile acid transmembrane transporter activitySLCO1F1;AKR1C4;SLCO1D1;SLCO1C1;SLCO2B1;SLCO1A6;SLCO1B3;SLCO1F2;SLCO1F3
chlordecone reductase activity
electron carrier activityGLRX2;COX5A;ACADS;IVD;ACAD9;P4HA2;ACAD8;GRX2;GLRX3
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorAKR1C3;AKR1C21;NDUFS7;AKR1C4;DCXR;CBR1;DHRS4;AKR1C2;AKR1C6
retinal dehydrogenase activityAldh1a7;ALDH8A1;ALDH1A3;AKR1B8;AKR1C6;AKR1C3;ALDH1A1;AKR1C4;AKR1B10

AKR1C4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C4.

  • Reviews
  • Q&As

Customer Reviews (4)

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Reviews
12/06/2022

    The AKR1C4 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.

    02/05/2021

      One notable advantage of the AKR1C4 protein is the excellent technical support provided by its manufacturer.

      10/02/2020

        Renowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.

        08/06/2016

          Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.

          Q&As (11)

          Ask a question
          Are there any ongoing clinical trials targeting AKR1C4? 12/04/2021

          Currently, there are limited ongoing clinical trials specifically targeting AKR1C4. However, there are studies investigating the role of AKR1C4 in cancer and drug metabolism, which may indirectly contribute to the development of targeted therapies. Ongoing research may uncover additional therapeutic opportunities for AKR1C4 and lead to the initiation of clinical trials in the future.

          Are there any known drug interactions or adverse effects associated with AKR1C4 inhibitors? 11/13/2021

          While AKR1C4 inhibitors have shown potential therapeutic benefits, they may also have interactions with other medications. This is particularly relevant in the context of drug metabolism, as AKR1C4 plays a role in the clearance of certain drugs. Therefore, the use of AKR1C4 inhibitors in combination with other medications should be carefully evaluated to avoid potential adverse effects or altered drug concentrations in the body. Additionally, the specific side effects or toxicity profiles of AKR1C4 inhibitors may vary depending on the compound used and further studies are needed to fully understand their safety profile.

          What are the tissue distribution and cellular localization of AKR1C4? 10/21/2021

          AKR1C4 is expressed in various tissues, including the liver, kidney, prostate, breast, and lung. It is found in both the cytoplasm and nucleus of cells. The specific cellular localization of AKR1C4 can vary depending on the cell type and its specific functions within that cell.

          Can targeting AKR1C4 have therapeutic implications? 02/02/2021

          Targeting AKR1C4 has emerged as a potential therapeutic strategy in certain conditions. Inhibition of AKR1C4 activity may be explored for the treatment of hormone-dependent cancers, such as prostate cancer. Additionally, modulating AKR1C4 activity may have implications for conditions involving inflammation and immune responses. However, further research is needed to fully understand its therapeutic potential.

          Is AKR1C4 used as a biomarker for any diseases or conditions? 02/19/2020

          Currently, AKR1C4 is not widely used as a biomarker for specific diseases or conditions. However, its expression and activity levels have been investigated in various studies as a potential biomarker for certain cancers and inflammatory disorders. Further research is needed to determine its clinical utility as a biomarker.

          Is AKR1C4 involved in any genetic disorders? 01/24/2020

          Yes, mutations in the AKR1C4 gene have been associated with a rare genetic disorder called congenital adrenal hyperplasia (CAH). CAH is characterized by impaired steroid hormone production and can manifest as ambiguous genitalia in affected individuals.

          What are the potential therapeutic applications of targeting AKR1C4? 09/25/2018

          Targeting AKR1C4 has shown potential therapeutic applications in various fields. In cancer treatment, inhibiting AKR1C4 can potentially enhance the efficacy of chemotherapy drugs by preventing their inactivation. AKR1C4 inhibitors may also be useful in the treatment of hormone-related cancers such as breast and prostate cancers, as the enzyme is involved in the metabolism of sex hormones. Additionally, targeting AKR1C4 may be explored in the development of therapies for endometriosis, neuroinflammatory conditions, and hypertension, based on its involvement in these diseases.

          Are there any known genetic variations or polymorphisms in AKR1C4? 06/24/2017

          Yes, several genetic variations and polymorphisms in AKR1C4 have been identified. Some of these variations have been associated with altered enzyme activity and drug metabolism. Certain polymorphisms may also impact the susceptibility to certain diseases or influence the response to specific medications. However, more research is needed to fully understand the functional impact of these genetic variations.

          Are there any specific inhibitors or activators of AKR1C4? 02/19/2017

          Several compounds have been identified as inhibitors or activators of AKR1C4. For example, various nonsteroidal anti-inflammatory drugs (NSAIDs) such as flufenamic acid and its analogs have been shown to inhibit AKR1C4 activity. On the other hand, some compounds like resveratrol and certain phytoestrogens can activate AKR1C4. However, the specificity and selectivity of these compounds towards AKR1C4 and their potential therapeutic applications require further investigation.

          Does AKR1C4 have any physiological or pathophysiological roles outside of cancer and drug metabolism? 05/27/2016

          Yes, AKR1C4 is involved in various physiological and pathophysiological processes outside of cancer and drug metabolism. It plays a role in the regulation of blood pressure by metabolizing important vasoactive compounds called prostaglandins. AKR1C4 is also implicated in endometriosis, a gynecological disorder characterized by the growth of endometrial tissue outside the uterus. Additionally, recent studies have suggested a potential role for AKR1C4 in neuroinflammation and neurological disorders.

          How is AKR1C4 related to drug metabolism? 03/22/2016

          AKR1C4 is involved in the metabolism of various drugs and xenobiotics. It can catalyze the reduction or oxidation of certain compounds, influencing their pharmacological properties and elimination from the body. AKR1C4 plays a role in the metabolism of nonsteroidal anti-inflammatory drugs (NSAIDs), anti-inflammatory corticosteroids, and some antipsychotic medications.

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