AKR1C4 Protein


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Official Full Name aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms AKR1C4; aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4); CHDR; aldo-keto reductase family 1 member C4; 3 alpha HSD; C11; CDR; DD4; HAKRA; MGC22581; 3-alpha-HSD1; di
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1C4-1269H Recombinant Human AKR1C4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AKR1C4-177H Recombinant Human AKR1C4 Protein, His-tagged E.coli His
    Human AKR1C4-218H Recombinant Human AKR1C4, His-tagged E.coli His
    Human AKR1C4-29344TH Recombinant Human AKR1C4, His-tagged E.coli His
    Human AKR1C4-414H Recombinant Human AKR1C4 Protein, GST-tagged Wheat Germ GST
    Human AKR1C4-721H Recombinant Human AKR1C4 E.coli N/A
    Human AKR1C4-8929HCL Recombinant Human AKR1C4 293 Cell Lysate HEK293 N/A
    Human AKR1C4-9534H Recombinant Human AKR1C4, GST-tagged E.coli GST
    Rhesus Macaque AKR1C4-294R Recombinant Rhesus monkey AKR1C4 Protein, His-tagged Mammalian Cell His
    Human AKR1C4-1006H Recombinant Human AKR1C4 protein, His-tagged E.coli His

    AKR1C4 involved in several pathways and played different roles in them. We selected most pathways AKR1C4 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Benzo(a)pyrene metabolism AKR1A1; FAM84B; CYP1A1; CYP3A4; AKR1C2; AKR1C4; CYP1B1
    Bile acid and bile salt metabolism AKR1C4; SLC27A2; Alb; SLC27A5; AKR1C6; AKR1C21; AKR1C2; SLCO1B1; ACOT8; BRSK2
    Metabolic pathways CYP2P9; LIPCA; DHODH; GOT2A; AGMAT; ACSL1A; PIK3C2G; PIP5K1C; C1GALT1; MTMR1
    Metabolism of lipids and lipoproteins CYP4F11; NEU4; FABP9; NFYBB; ALOX5B.3; ACOT11; MED23; CPNE7; APOA4B.2; CERS4A
    Metabolism of xenobiotics by cytochrome P450 GSTK1; AKR1C4; PRKRA; ADH2-2; ADH2-1; AKR1C2; CYP2S1; CYP2F1
    Primary bile acid biosynthesis CYP46A1.2; HSD3B7; BRSK2; HSD17B4; CYP8B1; CH25HL1.2; CYP39A1; ACOX2; CYP46A1.3; CYP46A1
    Retinoid metabolism and transport APOC2; LRP10; APOA4B.1; RBP2A; BCO2; APOA4B.2; AKR1C4; APOM; BCO2A; LRP12

    AKR1C4 has several biochemical functions, for example, aldo-keto reductase (NADP) activity, androsterone dehydrogenase activity, bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C4 itself. We selected most functions AKR1C4 had, and list some proteins which have the same functions with AKR1C4. You can find most of the proteins on our site.

    Function Related Protein
    aldo-keto reductase (NADP) activity KCNAB2; HSD11B1LA; SDR16C6; HSD3B5; KCNAB1; AKR1B1; AKR1C21; MIOX; SPR; AKR1C3
    androsterone dehydrogenase activity AKR1C4; AKR1C6; AKR1C3; AKR1C21
    bile acid transmembrane transporter activity SLCO1B3; SLCO2B1; SLCO1F2; SLCO1A4; SLCO1A5; SLCO1D1; SLCO1F1; SLCO1A6; SLCO1A2; AKR1C4
    chlordecone reductase activity AKR1C4
    electron carrier activity ALDH4A1; FDX1B; GCDHB; GRXCR1; NQO2; GRX2; ETFB; AKR1C4; ACAD8; TSTA3
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor AKR1C4; CBR1; DCXR; NDUFS7; DHRS4; AKR1C6; AKR1C3; AKR1C2; AKR1C21
    retinal dehydrogenase activity ALDH1A3; AKR1C4; Aldh1a7; ALDH1A1; AKR1B8; ALDH8A1; AKR1B10; AKR1C3; AKR1C6

    AKR1C4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C4.

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