AKR1C4 involved in several pathways and played different roles in them. We selected most pathways AKR1C4 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Benzo(a)pyrene metabolism |
FAM84B; CYP1B1; AKR1C4; CYP1A1; AKR1A1; AKR1C2; CYP3A4 |
| Bile acid and bile salt metabolism |
ACOT8; SLC27A5; SCP2B; SLC27A2A; CYP46A1; BRSK2; CYP8B2; AKR1C6; AKR1C2; SLC27A2 |
| Metabolic pathways |
B4GALT7; FUT9; CCBL2; PDXK; AMY1A; GMPPAB; ST6GAL2A; GALCA; SCP2A; GAL3ST1A |
| Metabolism |
GYG1A; SLC35D2; ADA; INSIG2; SLC6A8; PPM1L; SLC25A15B; CYP2A7; COX11; CYP2K19 |
| Metabolism of lipids and lipoproteins |
GPAT2; SLCO1B1; CYP4T8; SLC44A5B; CDK19; FABP9; MED25; MED6; DPEP2; ACOT6 |
| Metabolism of xenobiotics by cytochrome P450 |
CYP2F1; AKR1C2; AKR1C4; ADH2-2; PRKRA; CYP2S1; GSTK1; ADH2-1 |
| Primary bile acid biosynthesis |
HSD3B7; BAAT; CYP7A1A; CH25H; CYP8B1; CH25HL1.2; AKR1D1; AMACR; CYP46A1.4; CYP46A1.1 |
| Retinoid metabolism and transport |
BCO2; RBP4; APOC2; RBP1; APOM; BCO2A; LRP10; AKR1C21; LRP12; BCO2L |
AKR1C4 has several biochemical functions, for example, aldo-keto reductase (NADP) activity, androsterone dehydrogenase activity, bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C4 itself. We selected most functions AKR1C4 had, and list some proteins which have the same functions with AKR1C4. You can find most of the proteins on our site.
| Function |
Related Protein |
| aldo-keto reductase (NADP) activity |
AKR1C3; HSD11B1LA; AKR1C21; KCNAB1; HSD3B6; AKR1B1; AKR1C4; SPR; HSD3B5; MIOX |
| androsterone dehydrogenase activity |
AKR1C21; AKR1C6; AKR1C3; AKR1C4 |
| bile acid transmembrane transporter activity |
SLCO1A2; SLCO2B1; SLCO1B3; SLCO1D1; SLCO1B1; SLCO1F4; SLCO1A4; SLCO1A5; SLCO1A6; AKR1C4 |
| chlordecone reductase activity |
AKR1C4 |
| electron carrier activity |
XDH; ACADL; PTGES2; MAOB; CYCSB; GLRX3; HAAO; GCDHB; UGDH; AKR7A3 |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
AKR1C4; DHRS4; AKR1C2; CBR1; AKR1C6; DCXR; NDUFS7; AKR1C21; AKR1C3 |
| retinal dehydrogenase activity |
Aldh1a7; AKR1B8; AKR1B10; ALDH1A1; ALDH1A3; AKR1C3; AKR1C4; AKR1C6; ALDH8A1 |
AKR1C4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C4.
