akr1c4 Protein, aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

akr1c4

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akr1c4

Official Full Name aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms AKR1C4; aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4); CHDR; aldo-keto reductase family 1 member C4; 3 alpha HSD; C11; CDR; DD4; HAKRA; MGC22581; 3-alpha-HSD1; di
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1C4-1006H Recombinant Human AKR1C4 protein, His-tagged E.coli His
    Human AKR1C4-177H Recombinant Human AKR1C4 Protein, His-tagged E.coli His
    Human AKR1C4-218H Recombinant Human AKR1C4, His-tagged E.coli His
    Human AKR1C4-29344TH Recombinant Human AKR1C4, His-tagged E.coli His
    Human AKR1C4-414H Recombinant Human AKR1C4 Protein, GST-tagged Wheat Germ GST
    Human AKR1C4-721H Recombinant Human AKR1C4 E.coli N/A
    Human AKR1C4-8929HCL Recombinant Human AKR1C4 293 Cell Lysate HEK293 N/A
    Human AKR1C4-9534H Recombinant Human AKR1C4, GST-tagged E.coli GST
    Rhesus Macaque AKR1C4-294R Recombinant Rhesus monkey AKR1C4 Protein, His-tagged Mammalian Cell His

    akr1c4 involved in several pathways and played different roles in them. We selected most pathways akr1c4 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with akr1c4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Benzo(a)pyrene metabolism CYP1B1; AKR1C4; FAM84B; AKR1C2; CYP1A1; CYP3A4; AKR1A1
    Bile acid and bile salt metabolism SLC27A2; AKR1C21; ACOT8; CYP46A1; SLCO1B1; CYP8B2; CYP27A1; AKR1C4; SLC27A2A; NCOA2
    Metabolic pathways SPHK2; HMGCS2; GBE1; AOX2P; IDO1; OGDH; CDS1; PLCB4; PAPSS1; ACSL3A
    Metabolism NOSTRIN; ARF3; CKB; PAICS; SLC25A27; TPTE; COX7C; MED29; B3GNT1; SACM1L
    Metabolism of lipids and lipoproteins PHOSPHO1; NFYBB; ALOX5AP; FABP1B.1; APOC2; CYP2AD3; CPNE7; PNPLA8; COL4A3BP; GPAT2
    Metabolism of xenobiotics by cytochrome P450 CYP2F1; ADH2-2; GSTK1; CYP2S1; AKR1C2; PRKRA; AKR1C4; ADH2-1
    Primary bile acid biosynthesis BRSK2; CYP46A1.3; ACOX2; CYP46A1; CYP8B1; CH25HL2; CH25HL1.2; HSD3B7; AMACR; CYP46A1.4
    Retinoid metabolism and transport RBP1; CLPS; LRP12; APOA4B.2; APOA4A; AKR1C21; RBP4; RBP2A; BCO2A; BCO2L

    akr1c4 has several biochemical functions, for example, aldo-keto reductase (NADP) activity, androsterone dehydrogenase activity, bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by akr1c4 itself. We selected most functions akr1c4 had, and list some proteins which have the same functions with akr1c4. You can find most of the proteins on our site.

    Function Related Protein
    aldo-keto reductase (NADP) activity CYB5A; HSD11B1LA; SDR16C6; AKR1B10; SPR; HSD3B5; MIOX; HSD3B6; SDR42E1; AKR7A3
    androsterone dehydrogenase activity AKR1C3; AKR1C4; AKR1C6; AKR1C21
    bile acid transmembrane transporter activity AKR1C4; SLCO1F4; SLCO1F1; SLCO1A4; SLCO2B1; SLCO1B3; SLCO1A6; SLCO1A5; SLCO1B2; SLCO1A2
    chlordecone reductase activity AKR1C4
    electron carrier activity ALDH2; ME1; FDX1L; CYP19A1; QDPR; ACOX3; CYBA; ACAD11; GRX2; AIFM1
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor AKR1C6; CBR1; AKR1C4; DCXR; AKR1C3; AKR1C21; AKR1C2; NDUFS7; DHRS4
    retinal dehydrogenase activity AKR1B8; ALDH8A1; AKR1B10; AKR1C6; ALDH1A3; ALDH1A1; AKR1C3; Aldh1a7; AKR1C4

    akr1c4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with akr1c4 here. Most of them are supplied by our site. Hope this information will be useful for your research of akr1c4.

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