AKR1C4

  • Official Full Name

    aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
  • Synonyms

    AKR1C4;aldo-keto reductase family 1, member C4 (chlordecone reductase;3-alpha hydroxysteroid dehydrogenase, type I;dihydrodiol dehydrogenase 4);CHDR;aldo-keto reductase family 1 member C4;3 alpha HSD;C11;CDR;DD4;HAKRA;MGC22581;3-alpha-HSD1;di

Recombinant Proteins

  • Human
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
AKR1C4-1006H Active Recombinant Human AKR1C4 protein, His-tagged E.coli Human His 1-323 a.a.
AKR1C4-721H Active Recombinant Human AKR1C4 E.coli Human Non 1-323 a.a.
AKR1C4-177H Recombinant Human AKR1C4 Protein, His-tagged E.coli Human His
AKR1C4-218H Recombinant Human AKR1C4 protein, His-tagged E.coli Human His Met1-Tyr323
AKR1C4-29344TH Recombinant Human AKR1C4, His-tagged E.coli Human His 343 amino acids
AKR1C4-294R Recombinant Rhesus monkey AKR1C4 Protein, His-tagged Mammalian Cells Rhesus macaque His
AKR1C4-414H Recombinant Human AKR1C4 Protein, GST-tagged Wheat Germ Human GST
AKR1C4-8929HCL Recombinant Human AKR1C4 293 Cell Lysate HEK293 Human Non
AKR1C4-0270H Recombinant Human AKR1C4 Protein (Met1-Tyr323), N-GST-tagged E.coli Human GST Met1-Tyr323
AKR1C4-122R Recombinant Rhesus Macaque AKR1C4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
AKR1C4-122R-B Recombinant Rhesus Macaque AKR1C4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
AKR1C4-1269H Recombinant Human AKR1C4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
AKR1C4-1369HF Recombinant Full Length Human AKR1C4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 323 amino acids

    Involved Pathway

    AKR1C4 involved in several pathways and played different roles in them. We selected most pathways AKR1C4 participated on our site, such as Benzo(a)pyrene metabolism,Bile acid and bile salt metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways PDHA1A,CYP3A41A,PLA2G3,PLB1,AOX4,OXSR1,ALDH6A1,DAO.1,ALAS2,ATP6V1G3
    Bile acid and bile salt metabolism AKR1C6,CYP8B2,SLCO1B1,CYP7A1,CYP46A1,ACOT8,SCP2B,SLC27A2A,AKR1C2,NCOA2
    Benzo(a)pyrene metabolism CYP1A1,CYP3A4,CYP1B1,FAM84B,AKR1C2,AKR1A1
    Metabolism PPARGC1B,COX4I1,CHKA,NAALAD2,CYB5R3,GDF1,CYP2U1,PNP5B,CRYM,SLC25A32
    Retinoid metabolism and transport LRP10,BCO2L,BCO2A,RBP2A,AKR1C6,BCO2,RBP1,APOA4A,AKR1C21,LRP12
    Primary bile acid biosynthesis CH25H,BRSK2,HSD17B4,CYP46A1,CYP46A1.1,CYP46A1.4,SLC27A5,HSD3B7,CYP8B1,CYP46A1.2
    Metabolism of lipids and lipoproteins CYP4F11,ARV1,ARSD,FAM213B,FAAH2B,CYP24A1,SLC25A20,CDK19,AWAT2,ARSF
    Metabolism of xenobiotics by cytochrome P450 CYP2S1,ADH2-2,GSTK1,PRKRA,ADH2-1,CYP2F1,AKR1C2

    Protein Function

    AKR1C4 has several biochemical functions, for example, aldo-keto reductase (NADP) activity,androsterone dehydrogenase activity,bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C4 itself. We selected most functions AKR1C4 had, and list some proteins which have the same functions with AKR1C4. You can find most of the proteins on our site.

    Function Related Protein
    retinal dehydrogenase activity AKR1C6,ALDH1A1,AKR1B8,Aldh1a7,AKR1B10,AKR1C3,ALDH1A3,ALDH8A1
    androsterone dehydrogenase activity AKR1C6,AKR1C21,AKR1C3
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor AKR1C2,DCXR,CBR1,AKR1C6,AKR1C21,NDUFS7,DHRS4,AKR1C3
    electron carrier activity UGDH,ACADS,FDX1L,FDX1,DHRS3,SDHB,LOXL2,AKR7A2,SDHD,NDUFV2
    aldo-keto reductase (NADP) activity KCNAB2,SDR42E1,AKR1C3,CYB5A,AKR1C21,HSD11B1LA,AKR1B1,KCNAB1,HSD3B6,AKR1B10
    bile acid transmembrane transporter activity SLCO1A5,SLCO1A6,SLCO1F1,SLCO1B3,SLCO1B1,SLCO1F3,SLCO1A2,SLCO1C1,SLCO1B2,SLCO1D1

    Interacting Protein

    AKR1C4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C4.

    Resources

    References

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