akr1d1 Protein, aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

akr1d1

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akr1d1

Official Full Name aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
Background The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.
Synonyms AKR1D1; aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); SRD5B1; 3-oxo-5-beta-steroid 4-dehydrogenase; 3o5bred; AK1D1_HUMAN; aldo keto reductase family 1 member D1 (delta 4 3 ketosteroid 5 beta reductase); Aldo keto reductase family 1 member D1; Aldo-keto reductase family 1 member D1; CBAS2; Delta(4) 3 ketosteroid 5 beta reductase; Delta(4) 3 oxosteroid 5 beta reductase; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase; steroid 5 beta reductasebeta polypeptide 1 (3 oxo 5 beta steroid delta 4 dehydrogenase beta 1); steroid 5 beta reductase; OTTHUMP00000208643; OTTHUMP00000208644; OTTHUMP00000208645; steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydro
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1D1-1674H Recombinant Human Aldo-Keto Reductase Family 1, Member D1 (Delta 4-3-Ketosteroid-5-Beta-Reductase), His-tagged Human His
    Human AKR1D1-28H Recombinant Human AKR1D1 protein E.coli N/A
    Human AKR1D1-3463H Recombinant Human AKR1D1 protein, His-tagged E.coli His
    Human AKR1D1-417H Recombinant Human AKR1D1 Protein, GST-tagged Wheat Germ GST
    Human AKR1D1-8928HCL Recombinant Human AKR1D1 293 Cell Lysate HEK293 N/A
    Mouse AKR1D1-1504M Recombinant Mouse AKR1D1 Protein Mammalian Cell His
    Rat AKR1D1-601R Recombinant Rat AKR1D1 Protein Mammalian Cell His
    Chicken AKR1D1-4802C Recombinant Chicken AKR1D1 Mammalian Cell His

    akr1d1 involved in several pathways and played different roles in them. We selected most pathways akr1d1 participated on our site, such as Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with akr1d1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Primary bile acid biosynthesis CYP46A1.4; SCP2; CYP46A1.3; AKR1C4; ACOX2; BAAT; SCP2A; CH25HL1.2; CH25HL2; HSD17B4
    Steroid hormone biosynthesis HSD17B12A; HSD3B5; UGT2A3; CYP19A1A; COMTB; SULT2B1; UGT1A6B; UGT1A3; STS; CYP2C38
    Metabolic pathways HMGCR; THTPA; MGAT3A; ITPA; ITPK1; HMGCRB; CDS2; COX6B2; CSAD; PGAM1

    akr1d1 has several biochemical functions, for example, delta4-3-oxosteroid 5beta-reductase activity, steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by akr1d1 itself. We selected most functions akr1d1 had, and list some proteins which have the same functions with akr1d1. You can find most of the proteins on our site.

    Function Related Protein
    delta4-3-oxosteroid 5beta-reductase activity AKR1D1; AKR1C3
    steroid binding UGT1A1; ESRRG; PAQR7B; ESRRGA; GPR30; HSD11B2; HSD3B4; PAQR7; PGRMC1; FAM84B

    akr1d1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with akr1d1 here. Most of them are supplied by our site. Hope this information will be useful for your research of akr1d1.

    Yanagi, T; Mizuochi, T; et al. Distinguishing primary from secondary Delta(4)-3-oxosteroid 5 beta-reductase (SRD5B1, AKR1D1) deficiency by urinary steroid analysis. CLINICAL ENDOCRINOLOGY 82:346-351(2015).
    Yang, F; He, YQ; et al. All-trans retinoic acid regulates hepatic bile acid homeostasis. BIOCHEMICAL PHARMACOLOGY 91:483-489(2014).

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