|Official Full Name||aminolevulinate, delta-, synthase 2|
|Background||The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.|
|Synonyms||ALAS2; aminolevulinate, delta-, synthase 2; aminolevulinate, delta , synthase 2 (sideroblastic/hypochromic anemia) , ASB; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; sideroblastic/hypochromic anemia; 5-aminolevulinic acid synthase; ALAS E; ALASE; ANH1; Delta aminolevulinate synthase; FLJ93603; OTTMUSP00000020679; XLSA; 5 @aminolevulinate synthase erythroid specific; 5 aminolevulinic acid synthase 2; 5-aminolevulinate synthase 2; 5-aminolevulinate synthase; Alas 2; ALAS; ALAS, erythroid; Aminolevulinic acid synthase 2, erythroid; ASB; Delta ALA synthase 2; Delta ALA synthetase; Delta aminolevulinate synthase 2; Erythroid specific ALAS; OTTHUMP00000023388; OTTHUMP00000023389; RP23-338A17.1; XLDPP; OTTHUMP00000204081; delta-ALA synthase 2; delta-ALA synthetase; 5-aminolevulinic acid synthase 2; delta-aminolevulinate synthase 2; XLEPP; ALAS-E|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ALAS2 involved in several pathways and played different roles in them. We selected most pathways ALAS2 participated on our site, such as Glycine, serine and threonine metabolism, Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Glycine, serine and threonine metabolism||PGAM2; PHGDH; AGXTA; ALAS2; ALAS1; SHMT2; GLYCTK; SRR; DAO.2; CBSA|
|Porphyrin and chlorophyll metabolism||UGT2A2; HMOX2A; UGT1A6B; HMOX2; BLVRB; UGT2A3; HCCSA.1; UGT2B7; ALAS2; PPOX|
|Metabolic pathways||GALCA; CYP3A41B; SQLE; PLA2G4C; PIGA; SRM; GAPDHS; CYP2C18; FAM213B; CYP8B1|
ALAS2 has several biochemical functions, for example, 5-aminolevulinate synthase activity, coenzyme binding, glycine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAS2 itself. We selected most functions ALAS2 had, and list some proteins which have the same functions with ALAS2. You can find most of the proteins on our site.
|5-aminolevulinate synthase activity||ALAS1; ALAS2|
|coenzyme binding||HMGCR; ATAT1; TDH2; NDUFA9A; WWOX; HMGCRA; ACAT1; HMGCRB; NDUFA9; TDH|
|glycine binding||GLRA2; GNMT; SIX2A; GRIN2B; GRIN3A; GSS; GLDC; GLRA4A; SRR; GRIN3B|
|protein binding||GDF5; DACT2; TTC25; POC1B; KDM1A; ALKBH6; USHBP1; NCOR1; FFAR2; LRRFIP1|
|pyridoxal phosphate binding||HINT2; GAD1; GOT1; GPT2L; PYGMA; GOT2A; GAD2; PROSC; LOC650128; AGXT2L2|
ALAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAS2.