Angptl1

  • Official Full Name

    angiopoietin-like 1

  • Overview

    Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.
  • Synonyms

    ANGPTL1; angiopoietin-like 1; ANGPT3; angiopoietin-related protein 1; ANG3; angioarrestin; AngY; ARP1; ANG-3; angiopoietin 3; angiopoietin-3; angiopoietin Y1; angiopoietin-like protein 1; dJ595C2.2 (angiopoietin Y1); UNQ162; dJ595C2.2; KIAA0351;

  • Recombinant Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Canine
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANGPTL1-534H Recombinant Human ANGPTL1 Protein, DDK-tagged Sf9 Insect Cell DDK
Human ANGPTL1-2061H Recombinant Human ANGPTL1, Fibrinogen-like Domain, FLAG-tagged HEK293 Flag
Human ANGPTL1-7867H Recombinant Human ANGPTL1 protein, His-tagged E.coli His Phe271~Asp491 (Accession # O95841)
Human ANGPTL1-553H Recombinant Human ANGPTL1 protein, GST-tagged Wheat Germ GST
Human ANGPTL1-26572TH Recombinant Human ANGPTL1, FLAG-tagged HEK293 FLAG 295 amino acids
Human ANGPTL1-1086HF Recombinant Full Length Human ANGPTL1 Protein, GST-tagged In Vitro Cell Free System GST 24-491 amino acids
Human ANGPTL1-0212H Recombinant Human ANGPTL1 Protein (Phe271-Asp491), His-tagged E.coli His Phe271-Asp491
Mouse Angptl1-7868M Recombinant Mouse Angptl1 protein, His-tagged E.coli His Phe270~Asp490 (Accession # Q640P2)
Mouse ANGPTL1-1637M Recombinant Mouse ANGPTL1 Protein Mammalian Cell His
Mouse Angptl1-1704M Recombinant Mouse Angiopoietin-like 1 Mammalian cells N/A
Mouse ANGPTL1-529M-B Recombinant Mouse ANGPTL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ANGPTL1-529M Recombinant Mouse ANGPTL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Angptl1-10521M-B Recombinant Mouse Angptl1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Angptl1-10521M Recombinant Mouse Angptl1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Angptl1-7869R Recombinant Rat Angptl1 protein, His & T7-tagged E.coli His/T7 Arg36~Leu297 (Accession # D4A593)
Canine ANGPTL1-162C Recombinant Canine ANGPTL1 protein(Glu197-Asp491), hFc-tagged HEK293 N-hFc Glu197-Asp491
Canine ANGPTL1-001CCL Recombinant Canine ANGPTL1 cell lysate Human Cell N/A
Chicken ANGPTL1-5043C Recombinant Chicken ANGPTL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Angptl1 involved in several pathways and played different roles in them. We selected most pathways Angptl1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Angptl1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

Angptl1 has several biochemical functions, for example, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Angptl1 itself. We selected most functions Angptl1 had, and list some proteins which have the same functions with Angptl1. You can find most of the proteins on our site.

Function Related Protein
receptor bindingFGF12A;NOS2;INSL3;PTK2B;SRI;PVRL1;STOML2;MYO1C;GSDMA2

Angptl1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Angptl1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Angptl1.

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Can ANGPTL1 be targeted for therapeutic purposes? 11/16/2022

Targeting ANGPTL1 for therapeutic purposes is an area of ongoing research. Due to its involvement in angiogenesis and adipogenesis, regulating ANGPTL1 levels or activity could have potential therapeutic implications in conditions such as cancer, obesity, and metabolic disorders. Developing specific ANGPTL1-targeted therapies, such as antibodies or small molecules, could provide potential treatment options. However, more research is necessary to fully understand the therapeutic potential of targeting ANGPTL1.

How is ANGPTL1 involved in adipogenesis? 09/07/2021

ANGPTL1 plays a role in adipogenesis, the process of fat cell development. It promotes the differentiation of preadipocytes, which are precursor cells for fat cells, into mature adipocytes. ANGPTL1 accomplishes this by binding to the α5β1 integrin receptor on preadipocytes. This interaction activates downstream signaling pathways that induce adipocyte differentiation and lipid accumulation.

Can ANGPTL1 affect glucose metabolism? 12/11/2020

Yes, ANGPTL1 has been implicated in the regulation of glucose metabolism. Studies have shown that ANGPTL1 expression is upregulated in response to insulin and high glucose levels. It has been suggested that ANGPTL1 may contribute to insulin sensitivity and glucose homeostasis by enhancing insulin signaling pathways and glucose uptake in specific tissues. However, the precise mechanisms through which ANGPTL1 affects glucose metabolism are still under investigation.

Can ANGPTL1 be used as a biomarker for any diseases? 08/26/2018

ANGPTL1 has been investigated as a potential biomarker for various diseases. For example, elevated levels of ANGPTL1 have been observed in the plasma of patients with certain types of cancer, such as colorectal cancer, ovarian cancer, and pancreatic cancer. It has also been suggested as a biomarker for kidney diseases, where increased levels of ANGPTL1 have been associated with renal function decline.

Are there any therapeutic implications of ANGPTL1? 08/14/2018

The inhibition or manipulation of ANGPTL1 has been considered as a potential therapeutic strategy in various contexts. In diseases where excessive angiogenesis is detrimental, such as cancer, inhibiting ANGPTL1 could potentially be utilized to restrict tumor vascularization and growth. Conversely, in conditions where promoting angiogenesis is beneficial, such as tissue repair and wound healing, boosting ANGPTL1 activity might be beneficial.

Is ANGPTL1 associated with any diseases or conditions? 11/18/2017

ANGPTL1 has been studied in relation to several diseases and conditions. Studies have suggested that it may be involved in the pathogenesis of cancers, such as breast cancer and liver cancer, where it can promote tumor growth and metastasis by stimulating angiogenesis. Furthermore, ANGPTL1 expression has been found to be altered in obesity and metabolic disorders, suggesting a potential role in metabolic regulation. However, more research is needed to fully understand the role of ANGPTL1 in these diseases and conditions.

Are there any known genetic variations or mutations in the ANGPTL1 gene? 04/23/2017

Genetic variations and mutations in the ANGPTL1 gene have been reported in various studies. Some genetic variants have been associated with altered ANGPTL1 expression levels or activity and have been linked to certain diseases or conditions. For example, single nucleotide polymorphisms (SNPs) in the ANGPTL1 gene have been associated with coronary artery disease and susceptibility to gestational diabetes mellitus.

Are there any known inhibitors or activators of ANGPTL1? 07/29/2016

Currently, there is limited information available on specific inhibitors or activators of ANGPTL1. Research in this area is still ongoing. However, modulating the expression of ANGPTL1 may be possible through various factors, such as growth factors, cytokines, or signaling pathways that can regulate the expression of angiopoietin-like proteins. Further studies are needed to identify potential regulators of ANGPTL1 activity.

How is ANGPTL1 involved in angiogenesis? 05/16/2016

ANGPTL1 is known to inhibit angiogenesis, the process of forming new blood vessels. It can interfere with the activity of angiogenic factors like vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), thus suppressing blood vessel formation. ANGPTL1 can compete with angiopoietins, which are crucial for blood vessel development, for binding to their receptors, Tie2 and Tie1. By doing so, ANGPTL1 disrupts the angiopoietin-Tie signaling pathway, inhibiting angiogenesis.

Can ANGPTL1 be used as a diagnostic marker for certain diseases? 03/18/2016

It is not currently known if ANGPTL1 can be used as a diagnostic marker for specific diseases. However, studies have indicated its potential as a biomarker in certain conditions. For instance, increased levels of ANGPTL1 have been associated with adverse vascular outcomes in patients with coronary artery disease. Nevertheless, further research is needed to validate ANGPTL1 as a reliable diagnostic marker for specific diseases.

Customer Reviews (5)

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Reviews
03/25/2023

    One of the primary advantages of the ANGPTL1 protein is its versatility in various trial applications.

    10/28/2019

      As a researcher utilizing the ANGPTL1 protein in my trials, I have been highly impressed with its numerous advantages that significantly contribute to the success of my experimental endeavors.

      10/16/2018

        It can be effectively employed in in vitro and in vivo studies, offering insights into the intricate mechanisms underlying angiogenesis, lipid metabolism, and cardiovascular diseases.

        05/12/2017

          Its purity and consistency enable accurate and precise data analysis, ensuring the integrity of my research outcomes.

          10/29/2016

            the ANGPTL1 protein's exceptional quality, reliability, and the manufacturer's unparalleled technical support make it a prime choice for researchers seeking to delve into the intricacies of angiogenesis, vascular development, and related fields.

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