ARHGEF12

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 12

  • Overview

    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12; rho guanine nucleotide exchange factor 12; KIAA0382; LARG; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine exchange factor (GEF) 12; Similar to Mouse Lsc oncogene;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF12-781H Recombinant Human ARHGEF12 protein, GST-tagged Wheat Germ GST
Human ARHGEF12-8734HCL Recombinant Human ARHGEF12 293 Cell Lysate HEK293 N/A
Human ARHGEF12-391H Recombinant Human ARHGEF12 protein, His-tagged E.coli His 367-558aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ARHGEF12 involved in several pathways and played different roles in them. We selected most pathways ARHGEF12 participated on our site, such as Vascular smooth muscle contraction, Axon guidance, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Vascular smooth muscle contractionMYH11;CALM2A;GUCY1A3;GNA11A;ADCY2B;GNA11;PLCB1;PPP1CAA;PLA2G4C
Axon guidancePHB;EFNA4;COL4A5;EPHA10;PAK7;EFNB1;DUSP6;COL4A3;RHOC
Platelet activationTLN1;ITPR1;PLCG2;PRKG1;PIK3CA;GP6;GP1BB;ITGB3;ITGB1
Regulation of actin cytoskeletonMYL5;MSNA;ITGA1;PPP1CA;GSNB;MYL1;PDGFRB;PPP1CAB;NRAS
TuberculosisCASP9;MRC2;LBP;IL1B;HLA-DQA1;CAMK2B;IFNB1;CALM1;IFNGR1
Pathways in cancerLPAR5;BMP2;GNB4;WNT9A;FGFR1;MAPK1;FZD7;GNG2;HRAS
Proteoglycans in cancerCAV2;TWIST1;MET;ROCK2;WNT7B;ITGAV;TLR2;PIK3R1;CBL

ARHGEF12 has several biochemical functions, for example, G-protein coupled receptor binding, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF12 itself. We selected most functions ARHGEF12 had, and list some proteins which have the same functions with ARHGEF12. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingPSAPL1;ITGB4;GNAI2B;SAA1;GNA15.1;GNA11A;PSAP;NMS;ADORA1
GTPase activator activityTBC1D10C;PGAM5;RGS12B;TBC1D14;ASAP2;OPHN1;ARHGAP1;GIT2B;ARHGAP42A
Rho guanyl-nucleotide exchange factor activityARHGEF10L;ARHGEF7;ARHGEF17;VAV2;ARHGEF1B;PLEKHG7;VAV3;DOCK9;FGD5
protein bindingCLEC4G;DISC1;AKTIP;MBD4;Trf;CEP120;ARPIN;FBXO5;SCG2

ARHGEF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF12.

IGF1R; RHOA; Lpar1; ORF; ABCA1; q7db74_eco57; Lpar2; o68742_yerpe; hmsH; ARRB2

Research Area

Related articles

Majumdar, M; Seasholtz, TM; et al. A Rho exchange factor mediates thrombin and G alpha(12)-induced cytoskeletal responses. JOURNAL OF BIOLOGICAL CHEMISTRY 274:26815-26821(1999).
  • Q&As
  • Reviews

Q&As (17)

Ask a question
Are there any animal models available to study ARHGEF12 function? 01/09/2023

Yes, animal models such as mice have been used to study ARHGEF12 function. Knockout mouse models, where the ARHGEF12 gene is disrupted or deleted, have been generated to investigate the physiological and behavioral consequences of its loss. These models can provide insights into the role of ARHGEF12 in development, neurological processes, and disease.

Can targeting ARHGEF12 have therapeutic potential? 01/29/2022

Yes, targeting ARHGEF12 has the potential for therapeutic intervention. Since dysregulation of ARHGEF12 contributes to cancer progression and metastasis, inhibiting its activity could impede these processes. Furthermore, understanding the role of ARHGEF12 in other diseases, such as cardiovascular disorders, may pave the way for developing novel therapeutic strategies.

Are there any known interacting proteins or molecular partners of ARHGEF12? 01/01/2022

Yes, ARHGEF12 can interact with a variety of proteins and molecules. For example, it can interact with certain Rho GTPases, such as RhoA and Rac1, to regulate their activation. ARHGEF12 can also associate with other signaling proteins, adaptor molecules, and cytoskeletal components to mediate its cellular functions.

Are there any diseases or disorders associated with dysregulation of ARHGEF12 expression or activity? 08/17/2021

Yes, dysregulation of ARHGEF12 has been implicated in several diseases. For example, alterations in ARHGEF12 expression have been observed in certain cancers, such as breast, lung, and colorectal cancers. Dysregulation of ARHGEF12 can contribute to tumor progression and metastasis by promoting cellular processes like migration and invasion.

Can ARHGEF12 be targeted for therapeutic purposes? 03/15/2021

The potential therapeutic targeting of ARHGEF12 is an area of ongoing research. Since ARHGEF12 is involved in various cellular processes and implicated in certain diseases, it represents a potential target for therapeutic intervention. However, further investigation is needed to understand its precise role in disease mechanisms and develop effective therapeutic strategies.

Can ARHGEF12 be regulated by post-translational modifications? 05/25/2020

Yes, post-translational modifications can regulate the activity and function of ARHGEF12. For instance, phosphorylation of specific sites on ARHGEF12 can modulate its activity and interaction with other proteins. Other post-translational modifications, such as acetylation, methylation, and ubiquitination, may also play a role in regulating ARHGEF12. These modifications can impact its stability, localization, and interaction with signaling partners.

How does ARHGEF12 regulate Rho GTPases? 10/15/2019

ARHGEF12 facilitates the exchange of GDP (guanosine diphosphate) for GTP (guanosine triphosphate) on Rho GTPases. This GTP binding leads to the activation of Rho GTPases, allowing them to interact with downstream effectors and regulate cytoskeletal dynamics and other cellular functions.

Are there any drugs or compounds that target ARHGEF12? 07/18/2019

Currently, there are no specific drugs or compounds that directly target ARHGEF12. However, there are drugs that indirectly modulate the activity or downstream effects of Rho GTPases, which can indirectly affect ARHGEF12 signaling. For example, inhibitors of Rho-associated protein kinases (ROCKs), which are downstream effectors of RhoA, can impact the cellular processes influenced by ARHGEF12. Additionally, compounds targeting other pathways that intersect with ARHGEF12-mediated signaling, such as inhibitors of signaling pathways associated with cancer metastasis, may indirectly affect ARHGEF12 activity.

Is ARHGEF12 involved in neuronal development or synaptic plasticity? 07/04/2019

Yes, ARHGEF12 plays a role in neuronal development and synaptic plasticity. It has been found to be involved in the regulation of dendritic spine morphology, synapse formation, and axon guidance. Disruptions in ARHGEF12 function can impact these processes, potentially leading to neurological disorders.

Are there any known genetic mutations or variations in the ARHGEF12 gene? 06/08/2019

Yes, genetic variations and mutations have been identified in the ARHGEF12 gene. Some of these variations have been associated with certain diseases or disorders. For example, a specific mutation in the ARHGEF12 gene has been linked to familial juvenile myoclonic epilepsy (JME), a type of seizure disorder.

How does ARHGEF12 contribute to cancer progression? 05/29/2019

ARHGEF12 can contribute to cancer progression through its effects on cell migration, invasion, and metastasis. Dysregulation of ARHGEF12 can lead to aberrant cytoskeletal remodeling, promoting the invasive behavior of cancer cells. In addition, studies have shown that ARHGEF12-mediated signaling can activate downstream pathways involved in cell survival, proliferation, and angiogenesis, which are important for tumor growth and metastasis. These findings suggest that ARHGEF12 may be a potential therapeutic target for inhibiting cancer progression.

Are there any known inhibitors or activators of ARHGEF12? 03/06/2019

Yes, a few compounds have been identified as regulators of ARHGEF12 activity. For instance, Ipatasertib, a small molecule inhibitor, can inhibit the activity of ARHGEF12. Additionally, ARHGEF12 can be activated by various signals, including protein kinases like PKD1, which phosphorylates and activates ARHGEF12, leading to Rho GTPase activation.

Does ARHGEF12 have any known roles in immune responses? 02/13/2019

While ARHGEF12's role in immune responses is less well-studied compared to other cellular processes, emerging evidence suggests its involvement in immune cell migration and activation. ARHGEF12 has been shown to regulate cytoskeletal remodeling in immune cells, which can impact their ability to migrate and respond to stimuli. Further research is needed to fully elucidate its role in immune responses.

Has ARHGEF12 been implicated in any human diseases? 10/13/2018

Yes, ARHGEF12 has been implicated in several human diseases and disorders. For instance, mutations or variations in the ARHGEF12 gene have been associated with familial juvenile myoclonic epilepsy (JME). ARHGEF12 has also been implicated in the progression of certain types of cancer, including colorectal cancer and breast cancer. Its dysregulation has been linked to aberrant cytoskeletal dynamics and invasive behavior in cancer cells.

How is ARHGEF12 involved in cytoskeletal remodeling? 06/08/2018

ARHGEF12 plays a crucial role in cytoskeletal remodeling through its activation of Rho GTPases, particularly RhoA and Rac1. ARHGEF12 acts as a guanine nucleotide exchange factor (GEF), facilitating the exchange of GDP (inactive form) for GTP (active form) on Rho GTPases. This activation leads to downstream signaling cascades that regulate actin polymerization, cell adhesion, and cell migration. By modulating the activity of Rho GTPases, ARHGEF12 can influence the organization and dynamics of the cytoskeleton.

Are there any ongoing clinical trials involving ARHGEF12? 05/07/2018

As of now, there are no ongoing clinical trials specifically targeting ARHGEF12. However, this may change in the future as more research uncovers its potential therapeutic relevance in diseases such as epilepsy and cancer. It is always recommended to regularly check clinical trial databases for updates on ARHGEF12-related trials.

Is ARHGEF12 expressed in all tissues? 02/21/2016

ARHGEF12 is broadly expressed in various tissues and cell types. Its expression levels can vary depending on the specific tissue and developmental stage. Higher expression levels of ARHGEF12 are often detected in tissues with high actin remodeling, such as the brain, heart, skeletal muscle, and immune cells. However, it is important to note that expression patterns can vary depending on the specific physiological or pathological context.

Customer Reviews (8)

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Reviews
07/26/2022

    ARHGEF12 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.

    04/23/2019

      Their knowledgeable and responsive team of experts is readily available to provide guidance, troubleshooting assistance, and answer any inquiries or concerns I may have.

      01/05/2019

        They ensure a reliable and consistent supply of ARHGEF12 protein, minimizing any potential disruptions in my experimental workflow.

        03/07/2018

          The ARHGEF12 protein offers exceptional quality that meets the rigorous demands of experimental research.

          01/28/2018

            Whether it involves experimental design, protocol optimization, or data analysis, their expertise can help me navigate through complexities, saving valuable time and resources.

            01/22/2017

              They ensure a reliable and consistent supply of ARHGEF12 protein, minimizing any potential disruptions in my experimental workflow.

              05/12/2016

                ARHGEF12 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.

                03/11/2016

                  It exhibits exceptional performance in ELISA assays, making it an excellent choice for researchers studying angiopoietins, angiogenesis, or vascular biology.

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