ARHGEF12
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 12 -
Overview
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGEF12;Rho guanine nucleotide exchange factor (GEF) 12;rho guanine nucleotide exchange factor 12;KIAA0382;LARG;leukemia-associated rho guanine nucleotide exchange factor;Leukemia-associated RhoGEF;PRO2792;Rho guanine exchange factor (GEF) 12;Similar to Mouse Lsc oncogene
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGEF12-781H | Recombinant Human ARHGEF12 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGEF12-8734HCL | Recombinant Human ARHGEF12 293 Cell Lysate | HEK293 | Human | Non |
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| ARHGEF12-391H | Recombinant Human ARHGEF12 protein, His-tagged | E.coli | Human | His | 367-558aa |
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Involved Pathway
ARHGEF12 involved in several pathways and played different roles in them. We selected most pathways ARHGEF12 participated on our site, such as Vascular smooth muscle contraction,Axon guidance,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | RBX1,PLCB3,LPAR3,BAD,HSP90AA1,FGFR3,WNT7A,TGFB2,RASGRP3,HRAS |
| Platelet activation | RAP1A,PRKACG,ITGB1,GNAS,FGB,STIM1,LYN,VAMP8,PRKACB,Adcy4 |
| Vascular smooth muscle contraction | RHOA,CALM3B,PRKCA,MLCK2,ROCK1,RAF1A,CACNA1C,PRKCQ,CYP4A10,AGTR1A |
| Regulation of Actin Cytoskeleton | GSNB,FGF11A,EZRB,ITGB2,SSH2,ITGA11A,FN1,LIMK2,PIP5K1BA,FGF9 |
| Tuberculosis | HSPD1,IL1B,SPHK2,IL6,CALM3,LBP,STAT1,IL12B,ATP6V1H,CD209A |
| Axon guidance | EVL,TRPC7,EPHA2,EFNB2A,GDNF,EPHA7,CXCR4,CSNK2A2,SPTBN2,SEMA6A |
| Proteoglycans in cancer | EZR,ROCK2,PRKCA,WNT3,ACTB,RPS6KB1,CAV1,HIF1A,WNT9A,SLC9A1 |
Protein Function
ARHGEF12 has several biochemical functions, for example, G-protein coupled receptor binding,GTPase activator activity,Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF12 itself. We selected most functions ARHGEF12 had, and list some proteins which have the same functions with ARHGEF12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RP2,RASGRP3,DLC1,ARHGAP17,RIC8B,TBC1D14,TBC1D17,RGS3A,ADAP1,ADAP2 |
| protein binding | TACSTD2,PPP6R2,AP1G1,SNX27,EZR,PDXP,FOXB1,NPC1,ORC1L,KCNJ9 |
| G-protein coupled receptor binding | CORT,PROK1,HSPA1B,HSPA8,PPY,GNA13A,HSPA1A,GNAT3,NPB,RSPO4 |
| Rho guanyl-nucleotide exchange factor activity | DOCK9,ARHGEF3L,ARHGEF1B,ARHGEF18A,ARHGEF18,FARP2,TIAM2,ARHGEF9B,ARHGEF17,ARHGEF15 |
Interacting Protein
ARHGEF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF12.
IGF1R;RHOA;Lpar1;ORF;ABCA1;q7db74_eco57;Lpar2;o68742_yerpe;hmsH;ARRB2
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References
- Majumdar, M; Seasholtz, TM; et al. A Rho exchange factor mediates thrombin and G alpha(12)-induced cytoskeletal responses. JOURNAL OF BIOLOGICAL CHEMISTRY 274:26815-26821(1999).
