ASCL2
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Official Full Name
achaete-scute complex homolog 2 (Drosophila)
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Overview
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. -
Synonyms
ASCL2; achaete-scute complex homolog 2 (Drosophila); achaete scute complex (Drosophila) homolog like 2 , achaete scute complex like 2 (Drosophila); achaete-scute homolog 2; ASH2; bHLHa45; HASH2; Achaete scute complex like 2; Achaete scute homolog 2; achaete-scute complex-like 2; ASCL2_HUMAN; ASH-2; Class A basic helix-loop-helix protein 45; Mash2; OTTHUMP00000011229; mammalian achaete/scute homologue 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ASCL2 involved in several pathways and played different roles in them. We selected most pathways ASCL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ASCL2 has several biochemical functions, for example, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCL2 itself. We selected most functions ASCL2 had, and list some proteins which have the same functions with ASCL2. You can find most of the proteins on our site.
Function | Related Protein |
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E-box binding | NEUROG2;ZEB1;MYC;BHLHE40;LMO2;ATOH8;ASCL1;MYOG;C1orf51 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOSL2;NRF1;PITX2;KCNIP3;NR5A2;KLF13;IFI203;HAND1;POU4F2 |
protein dimerization activity | ACTN2;PIP;STK4;ATOH7;HNF1A;AHRRA;STAT5B;HER5;HER12 |
transcription factor activity, sequence-specific DNA binding | FOXD4;POU5F1;PBX1;RARG;TBX16;ZNF193;FOXN1;FOXN2;POU3F2A |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | SKIL;TFAP2C;HES1;NKX6;BATF3;NFIL3-2;YY1;KLF17;AEBP2 |
ASCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCL2.
Research Area
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Customer Reviews (3)
Write a reviewThe manufacturer's commitment to providing excellent technical support is highly valuable.
The combination of high-quality ASCL2 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.
The ASCL2 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.
Q&As (6)
Ask a questionASCL2, along with other transcription factors and signaling molecules, has been used in combination to induce cellular reprogramming and pluripotency in certain contexts, demonstrating its ability to alter cell fate.
ASCL2's primary role is in the gastrointestinal tract, but it may also have roles in other tissues and organs during development, including lung and pancreas.
ASCL2 interacts with various co-factors and proteins involved in stem cell regulation and development, including β-catenin, POU5F1 (Oct4), and SMAD proteins.
Yes, ASCL2 is crucial for the normal development of the gastrointestinal tract, particularly in regulating the differentiation and proliferation of intestinal stem cells.
ASCL2 is being explored as a potential therapeutic target for colorectal cancer due to its involvement in promoting abnormal cell proliferation. Targeting ASCL2 may help inhibit tumor growth and progression.
ASCL2 promotes the self-renewal of intestinal stem cells by activating specific gene expression programs involved in stem cell maintenance. It also regulates the balance between proliferation and differentiation of these cells.
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