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Recombinant Human ASCL2 protein, GST-tagged

Cat.No. : ASCL2-905H
Product Overview : Recombinant Human ASCL2(1 a.a. - 193 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.
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  • Gene Information
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Description : This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 46.6 kDa
Protein length : 1 a.a. - 193 a.a.
AA Sequence : MDGGTLPRSAPPAPPVPVGCAARRR PASPELLRCSRRRRPATAETGGGAA AVARRNERERNRVKLVNLGFQALRQ HVPHGGASKKLSKVETLRSAVEYIR ALQRLLAEHDAVRNALAGGLRPQAV RPSAPRGPPGTTPVAASPSRASSSP GRGGSSEPGSPRSAYSSDDSGCEGA LSPAERELLDFSSWLGGY
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : ASCL2 achaete-scute complex homolog 2 (Drosophila) [ Homo sapiens ]
Official Symbol : ASCL2
Synonyms : ASCL2; achaete-scute complex homolog 2 (Drosophila); achaete scute complex (Drosophila) homolog like 2 , achaete scute complex like 2 (Drosophila); achaete-scute homolog 2; ASH2; bHLHa45; HASH2; ASH-2; achaete-scute complex-like 2; mammalian achaete/scute homologue 2; class A basic helix-loop-helix protein 45; MASH2;
Gene ID : 430
mRNA Refseq : NM_005170
Protein Refseq : NP_005161
MIM : 601886
UniProt ID : Q99929

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can ASCL2 induce pluripotency or cellular reprogramming? 01/12/2023

ASCL2, along with other transcription factors and signaling molecules, has been used in combination to induce cellular reprogramming and pluripotency in certain contexts, demonstrating its ability to alter cell fate.

Does ASCL2 have any role in other tissues or organs? 01/10/2023

ASCL2's primary role is in the gastrointestinal tract, but it may also have roles in other tissues and organs during development, including lung and pancreas.

Are there any known interacting partners of ASCL2? 09/30/2019

ASCL2 interacts with various co-factors and proteins involved in stem cell regulation and development, including β-catenin, POU5F1 (Oct4), and SMAD proteins.

Is ASCL2 essential for the development of the gastrointestinal tract? 06/14/2019

Yes, ASCL2 is crucial for the normal development of the gastrointestinal tract, particularly in regulating the differentiation and proliferation of intestinal stem cells.

Can ASCL2 be targeted for therapeutic interventions or drug discovery? 04/06/2017

ASCL2 is being explored as a potential therapeutic target for colorectal cancer due to its involvement in promoting abnormal cell proliferation. Targeting ASCL2 may help inhibit tumor growth and progression.

How does ASCL2 regulate intestinal stem cells? 02/17/2016

ASCL2 promotes the self-renewal of intestinal stem cells by activating specific gene expression programs involved in stem cell maintenance. It also regulates the balance between proliferation and differentiation of these cells.

Customer Reviews (3)

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Reviews
06/08/2022

    The manufacturer's commitment to providing excellent technical support is highly valuable.

    05/02/2018

      The combination of high-quality ASCL2 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

      07/15/2017

        The ASCL2 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

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