• Official Full Name

    ATPase, Na+/K+ transporting, alpha 2 polypeptide

  • Background

    The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
  • Synonyms

    ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide , MHP2, migraine, hemiplegic 2; sodium/potassium-transporting ATPase subunit alpha-2; FHM2; KIAA0778; Na+/K+ATPase alpha 2 subunit; AT1A2_HUMAN; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; sodium-potassium ATPase; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; sodium/potassium-transporting ATPase alpha-2 chain;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken ATP1A2-7025C Recombinant Chicken ATP1A2 Mammalian Cell His
    Human ATP1A2-366H Recombinant Human ATP1A2 protein, GST-tagged E. coli GST
    Human ATP1A2-365H Recombinant Human ATP1A2 Mammalian Cell His
    Human ATP1A2-2516H Recombinant Human ATP1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human ATP1A2-8612HCL Recombinant Human ATP1A2 293 Cell Lysate HEK293 N/A
    Human ATP1A2-2516H-B Recombinant Human ATP1A2 Protein Pre-coupled Magnetic Beads HEK293
    Human ATP1A2-10005H Recombinant Human ATP1A2, His-tagged E.coli His
    Human ATP1A2-0550H Recombinant Human ATP1A2 Protein (Lys347-Glu700), N-His-tagged E.coli N-His
    Rat ATP1A2-509R Recombinant Rat ATP1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat ATP1A2-509R-B Recombinant Rat ATP1A2 Protein Pre-coupled Magnetic Beads HEK293
    Rat ATP1A2-853R Recombinant Rat ATP1A2 Protein Mammalian Cell His
    Rhesus Macaque ATP1A2-276R Recombinant Rhesus Macaque ATP1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque ATP1A2-276R-B Recombinant Rhesus Macaque ATP1A2 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque ATP1A2-447R Recombinant Rhesus monkey ATP1A2 Protein, His-tagged Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    ATP1A2 involved in several pathways and played different roles in them. We selected most pathways ATP1A2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathwayAdcy4;GUCY1A3;TRPC6;GTF2I;ATP2B4;ROCK2;SRF;MYLK3;ROCK1
    cAMP signaling pathwayPLD2;CALM3;PTGER2;NPR1;ATP1A1;ATP1A2;AKT2;PTCH1;GHRL
    Cardiac muscle contractionUQCRC2;TPM4;UQCRB;COX5B2;CACNA1SA;ATP1B2;CACNG2;UQCRQ;MYL4
    Adrenergic signaling in cardiomyocytesCACNB3;MYL3;ATF6B;ACTC1;CREB3L1;TPM1;TPM4B;PPP2R2D;ATP2B3B
    Insulin secretionRAPGEF4;CREB5;PLCB1;INS1;KCNN1;CREB3L3;ATF4;KCNMA1;ATP1B4
    Thyroid hormone synthesisGNAS;ATP1B1;GPX5;HSPA5;ASGR2;GSR;DUOX2;PRKACA;ATP1B4
    Thyroid hormone signaling pathwayATP2A2;SIN3A;NCOA1;AKT2;MDM2;PRKACB;MAP2K1;PLCB1;SLC16A2
    Aldosterone-regulated sodium reabsorptionPRKCA;ATP1B4;PIK3CD;PIK3CA;PIK3CB;MAPK3;PIK3CG;HSD11B2;SLC9A3R2
    Endocrine and other factor-regulated calcium reabsorptionKLK1B8;GNAQ;ATP2B1;PLCB2;ESR1;FXYD2;PRKCG;PRKACB;PLCB1
    Proximal tubule bicarbonate reclamationSLC25A10;CA2;PCK2;ATP1B4;ATP1A3;ATP1B2;ATP1B1;ATP1A4;FXYD2
    Salivary secretionVAMP2;MUC5B;ATP2B4;CALM1;NOS1;TRPV6;ATP1B1;CALML5;GUCY1B3
    Gastric acid secretionITPR3;GNAI1;CALML3;CAMK2D;SSTR2;MYLK3;ATP1A4;PLCB1;KCNJ2
    Pancreatic secretionGNAS;PLCB3;PLA2G5;RYR2;KCNMA1;ATP1A4;CD38;PLA2G2D;PLA2G3
    Carbohydrate digestion and absorptionTAS1R3;HK3;PIK3R1;HKDC1;AMY2A4;AKT2;PIK3R3;PIK3CB;PRKCB
    Protein digestion and absorptionATP1A4;KCNQ1;CELA2B;ACE2;COL24A1;FXYD2;COL18A1;CPA3;CPA2
    Bile secretionSLC4A4;SLCO1A5;FXYD2;AQP1;SLC27A5;SLC2A1;SULT2A1;NR0B2;ADCY3
    Mineral absorptionHMOX1;MT1H;HEPH;SLC5A1;FTH1;ATP1A2;SLC26A6;MT1B;MT1M

    ATP1A2 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A2 itself. We selected most functions ATP1A2 had, and list some proteins which have the same functions with ATP1A2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ATP bindingMSH2;SFRP5;ATP1B1;ATP1A2;ATP5D;MSH6;ABCG8
    contributes_to ATPase activityATP5J2;ATP5B;RFC3;ATP5I;ATP5F1;ATP5D;ABCG8;PPP2R4;MSH2
    contributes_to drug bindingPGGT1B;ATP1A2;ATP1B1
    contributes_to potassium ion bindingATP1A2;ATP1B1
    contributes_to sodium ion bindingATP1A2;ATP1B1
    sodium:potassium-exchanging ATPase activityATP1A1A.2;ATP1A2;ATP1A1B;ATP12A;FXYD2;ATP1A2A;ATP1A3;ATP1A3B;ATP1B3
    contributes_to sodium:potassium-exchanging ATPase activityATP1A2;ATP1B2;ATP1A1;ATP1B1;ATP1B3
    steroid hormone bindingGPR30;ATP1A3;ATP1A2;ATP1A1;NR3C1;ESR2B;ESR2A

    ATP1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A2.


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