ATP1A2
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Official Full Name
ATPase, Na+/K+ transporting, alpha 2 polypeptide
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Background
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. -
Synonyms
ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide , MHP2, migraine, hemiplegic 2; sodium/potassium-transporting ATPase subunit alpha-2; FHM2; KIAA0778; Na+/K+ATPase alpha 2 subunit; AT1A2_HUMAN; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; sodium-potassium ATPase; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; sodium/potassium-transporting ATPase alpha-2 chain;
- Involved Pathway
- Protein Function
- Interacting Protein
ATP1A2 involved in several pathways and played different roles in them. We selected most pathways ATP1A2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | Adcy4;GUCY1A3;TRPC6;GTF2I;ATP2B4;ROCK2;SRF;MYLK3;ROCK1 |
| cAMP signaling pathway | PLD2;CALM3;PTGER2;NPR1;ATP1A1;ATP1A2;AKT2;PTCH1;GHRL |
| Cardiac muscle contraction | UQCRC2;TPM4;UQCRB;COX5B2;CACNA1SA;ATP1B2;CACNG2;UQCRQ;MYL4 |
| Adrenergic signaling in cardiomyocytes | CACNB3;MYL3;ATF6B;ACTC1;CREB3L1;TPM1;TPM4B;PPP2R2D;ATP2B3B |
| Insulin secretion | RAPGEF4;CREB5;PLCB1;INS1;KCNN1;CREB3L3;ATF4;KCNMA1;ATP1B4 |
| Thyroid hormone synthesis | GNAS;ATP1B1;GPX5;HSPA5;ASGR2;GSR;DUOX2;PRKACA;ATP1B4 |
| Thyroid hormone signaling pathway | ATP2A2;SIN3A;NCOA1;AKT2;MDM2;PRKACB;MAP2K1;PLCB1;SLC16A2 |
| Aldosterone-regulated sodium reabsorption | PRKCA;ATP1B4;PIK3CD;PIK3CA;PIK3CB;MAPK3;PIK3CG;HSD11B2;SLC9A3R2 |
| Endocrine and other factor-regulated calcium reabsorption | KLK1B8;GNAQ;ATP2B1;PLCB2;ESR1;FXYD2;PRKCG;PRKACB;PLCB1 |
| Proximal tubule bicarbonate reclamation | SLC25A10;CA2;PCK2;ATP1B4;ATP1A3;ATP1B2;ATP1B1;ATP1A4;FXYD2 |
| Salivary secretion | VAMP2;MUC5B;ATP2B4;CALM1;NOS1;TRPV6;ATP1B1;CALML5;GUCY1B3 |
| Gastric acid secretion | ITPR3;GNAI1;CALML3;CAMK2D;SSTR2;MYLK3;ATP1A4;PLCB1;KCNJ2 |
| Pancreatic secretion | GNAS;PLCB3;PLA2G5;RYR2;KCNMA1;ATP1A4;CD38;PLA2G2D;PLA2G3 |
| Carbohydrate digestion and absorption | TAS1R3;HK3;PIK3R1;HKDC1;AMY2A4;AKT2;PIK3R3;PIK3CB;PRKCB |
| Protein digestion and absorption | ATP1A4;KCNQ1;CELA2B;ACE2;COL24A1;FXYD2;COL18A1;CPA3;CPA2 |
| Bile secretion | SLC4A4;SLCO1A5;FXYD2;AQP1;SLC27A5;SLC2A1;SULT2A1;NR0B2;ADCY3 |
| Mineral absorption | HMOX1;MT1H;HEPH;SLC5A1;FTH1;ATP1A2;SLC26A6;MT1B;MT1M |
ATP1A2 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A2 itself. We selected most functions ATP1A2 had, and list some proteins which have the same functions with ATP1A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ATP binding | MSH2;SFRP5;ATP1B1;ATP1A2;ATP5D;MSH6;ABCG8 |
| contributes_to ATPase activity | ATP5J2;ATP5B;RFC3;ATP5I;ATP5F1;ATP5D;ABCG8;PPP2R4;MSH2 |
| chaperone binding | DNAJA2;PFDN6;HSCB;DLST;BAG1;BAG5;TBCC;TBCA;CLU |
| contributes_to drug binding | PGGT1B;ATP1A2;ATP1B1 |
| contributes_to potassium ion binding | ATP1A2;ATP1B1 |
| protein binding | BCL2A1A;NUCB2;MON2;SUDS3;ATRNL1;MAPKAPK5;SEC23IP;CTNNAL1;AMPH |
| contributes_to sodium ion binding | ATP1A2;ATP1B1 |
| sodium:potassium-exchanging ATPase activity | ATP1A1A.2;ATP1A2;ATP1A1B;ATP12A;FXYD2;ATP1A2A;ATP1A3;ATP1A3B;ATP1B3 |
| contributes_to sodium:potassium-exchanging ATPase activity | ATP1A2;ATP1B2;ATP1A1;ATP1B1;ATP1B3 |
| steroid hormone binding | GPR30;ATP1A3;ATP1A2;ATP1A1;NR3C1;ESR2B;ESR2A |
ATP1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A2.
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