ATP1A2

  • Official Full Name

    ATPase, Na+/K+ transporting, alpha 2 polypeptide

  • Overview

    The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
  • Synonyms

    ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide , MHP2, migraine, hemiplegic 2; sodium/potassium-transporting ATPase subunit alpha-2; FHM2; KIAA0778; Na+/K+ATPase alpha 2 subunit; AT1A2_HUMAN; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; sodium-potassium ATPase; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; sodium/potassium-transporting ATPase alpha-2 chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP1A2-10005H Recombinant Human ATP1A2, His-tagged E.coli His 347-700a.a.
Human ATP1A2-365H Recombinant Human ATP1A2 Mammalian Cell His
Human ATP1A2-8612HCL Recombinant Human ATP1A2 293 Cell Lysate HEK293 N/A
Human ATP1A2-366H Recombinant Human ATP1A2 protein, GST-tagged E.coli GST 347-700 aa
Human ATP1A2-2516H-B Recombinant Human ATP1A2 Protein Pre-coupled Magnetic Beads HEK293
Human ATP1A2-2516H Recombinant Human ATP1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP1A2-0550H Recombinant Human ATP1A2 Protein (Lys347-Glu700), N-His-tagged E.coli N-His Lys347-Glu700
Rat ATP1A2-853R Recombinant Rat ATP1A2 Protein Mammalian Cell His
Rat ATP1A2-509R Recombinant Rat ATP1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1A2-509R-B Recombinant Rat ATP1A2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP1A2-447R Recombinant Rhesus monkey ATP1A2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP1A2-276R-B Recombinant Rhesus Macaque ATP1A2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP1A2-276R Recombinant Rhesus Macaque ATP1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ATP1A2-7025C Recombinant Chicken ATP1A2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP1A2 involved in several pathways and played different roles in them. We selected most pathways ATP1A2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayPPP3R2;GNAI1;MYLK3;PDE5A;NPPB;MEF2D;FXYD2;ATP2A3;CREB3L3
cAMP signaling pathwayATP1A4;RRAS;PDE4C;PPP1CB;GLI1;GPR119;HCAR2;GHRL;GNAI1
Cardiac muscle contractionCACNG8;CACNB1;UQCR10;ATP1B3B;TNNC1;CACNA2D3;CACNB2A;ATP1A4;ATP1A1
Adrenergic signaling in cardiomyocytesATP2B1;MAPK12B;MAPK14B;MAPK13;TPM4;ATF2;FXYD2;GNAI1;ADCY1A
Insulin secretionKCNN4;CAMK2G;KCNMB3;ADCYAP1;ATP1A3;PRKCG;CAMK2B;SNAP25;CREB3L1
Thyroid hormone synthesisHSPA5;TPO;GPX2;ATP1A4;TSHB;PRKACA;CREB3L3;ATP1B2;HSP90B1
Thyroid hormone signaling pathwayCASP9;PLN;KRAS;ATP1A4;THRB;DIO2;ITGB3;FXYD2;PIK3R3
Aldosterone-regulated sodium reabsorptionKCNJ1;ALPHA-ENAC;ATP1B4;NR3C2;SCNN1B;PIK3CG;SLC9A3R2;PIK3CD;ATP1B2
Endocrine and other factor-regulated calcium reabsorptionATP1A2;ATP1B4;ESR1;KLK1B5;PTH1R;KLK1B22;ATP1A1;ATP1B2;PLCB2
Proximal tubule bicarbonate reclamationATP1B3;ATP1A3;ATP1A1;GLS2;GLUD1;CA4;ATP1A4;MDH1;GLUD2
Salivary secretionCST1;PRKACB;Slc4a2;TRPV6;LYZ;CAMP;DMBT1;PMAP-36;PLCB1
Gastric acid secretionSlc4a2;CALM4;CALML3;GNAS;CALM1;ATP1A4;ATP1B3;CAMK2G;KCNJ2
Pancreatic secretionATP1A3;CLCA3;ATP1B1;CELA2B;ATP2A1;BST1;FXYD2;PRKCB;ATP1A1
Carbohydrate digestion and absorptionTAS1R2;Amy1;SLC2A2;AMY1A;AMY2B;G6PC3;SLC37A4;ATP1B2;PIK3CD
Protein digestion and absorptionPRSS1;ELN;SLC7A7;COL18A1;CPB1;ATP1B1;COL10A1;KCNN4;FXYD2
Bile secretionSlc4a2;LDLR;ATP1A1;NR1H4;PRKACG;SCARB1;CYP7A1;FAM84B;ATP1B2
Mineral absorptionATP1B1;SLC11A1;MT2;ATP7A;MT1E;ATP1B4;SLC26A9;CYBRD1;CLCN2

ATP1A2 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A2 itself. We selected most functions ATP1A2 had, and list some proteins which have the same functions with ATP1A2. You can find most of the proteins on our site.

Function Related Protein
contributes_to ATP bindingATP5D;ABCG8;ATP1B1;MSH2;MSH6;ATP1A2;SFRP5
contributes_to ATPase activityATP5E;ATP5B;ATP5C1;ATP5H;ABCG8;ABCA7;MSH2;ATP5J2;RFC3
chaperone bindingH2-KE2;ERP29;HSPA5;HYOU1;DNAJB1;AHSA2;BAG1;CLU;C1orf182
contributes_to drug bindingPGGT1B;ATP1B1;ATP1A2
contributes_to potassium ion bindingATP1B1;ATP1A2
protein bindingRYR1;DPM3;TOP2A;AFF4;MAGEA3;SCG2;LIMS1;CD8B;EGFR
contributes_to sodium ion bindingATP1A2;ATP1B1
sodium:potassium-exchanging ATPase activityATP1A3B;ATP12A;ATP1A1B;ATP1A2;ATP1B3;ATP1A1A.4;ATP4A;ATP1A4;ATP1B2
contributes_to sodium:potassium-exchanging ATPase activityATP1B2;ATP1B1;ATP1A2;ATP1A1;ATP1B3
steroid hormone bindingGPR30;ATP1A3;ATP1A2;ESR2A;NR3C1;ATP1A1;ESR2B

ATP1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A2.

GABARAP

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