ATP2B4
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Official Full Name
ATPase, Ca++ transporting, plasma membrane 4
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Overview
Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene. -
Synonyms
ATP2B4; ATPase, Ca++ transporting, plasma membrane 4; plasma membrane calcium-transporting ATPase 4; AT2B4_HUMAN; ATP2B2; ATPase Ca++ transporting plasma membrane 4; Cation transporting ATPase; DKFZp686G08106; DKFZp686M088; Matrix remodelling associated 1; Matrix remodelling associated protein 1; Matrix-remodeling-associated protein 1; MXRA 1; MXRA1; OTTHUMP00000034088; OTTHUMP00000034089; Plasma membrane calcium ATPase 4; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Plasma membrane calcium transporting ATPase 4; PMCA 4; PMCA4; PMCA4b; PMCA4x; Sarcolemmal calcium pump; ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ATP2B4 involved in several pathways and played different roles in them. We selected most pathways ATP2B4 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Calcium signaling pathway | TRHR2;PLCZ1;PLCG2;VDAC1;SLC8A1;CAMK2G1;VDAC3;HTR4;CALM1B |
cGMP-PKG signaling pathway | ATP1A4;GNA11;PPP3R2;PDE5A;INS2;MAP2K1;NOS3;SLC25A31;IRS4 |
cAMP signaling pathway | RAP1A;FSHR;PDE4D;ATP1B3;GRIN2D;HTR1B;GNAI2;GIPR;CNGA4 |
Adrenergic signaling in cardiomyocytes | SCN1BA;PPP2R5EB;CACNB4;ACTC1A;CALM2A;PIK3CA;CACNG7;PPP1CC;ATP1A1 |
Salivary secretion | LYZ1;LYZ;PRH1;CALM2;BEST2;ATP1A4;ATP2B4;PRKCG;PLCB3 |
Pancreatic secretion | PLA2G10;ATP2A3;Cel;PLA2G2E;CPA3;ATP1B1;TRPC1;Car2;ATP1A3 |
ATP2B4 has several biochemical functions, for example, ATP binding, PDZ domain binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B4 itself. We selected most functions ATP2B4 had, and list some proteins which have the same functions with ATP2B4. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | LRGUK;MYH10;CAMKK2;NTRK3A;DQX1;Abcb1b;SCYL1;TTLL4;MYO1F |
PDZ domain binding | GRM7;KIDINS220B;Apba1;GRIA1;DTNA;CXXC4;SSTR2;NKD1;ATP2B1 |
calcium-transporting ATPase activity | ATP2A2;ATP2A2B;ATP2A1;ATP2B4;ATP2A2A;ATP2B2;ATP2A1L;ATP2C1;ATP2C2 |
calmodulin binding | STRN4;VAMP2;PDE1B;CAMK2D1;EEA1;ADD2;AKAP5;CAMK2A;MYH1 |
metal ion binding | USP4;RNF145B;AIFM4;S100A10B;ATP13A4;SCRT2;CYP2K16;CYP2AA8;ING5A |
nitric-oxide synthase binding | SNTA1;CD74;DNM3;ATP2B4;CDH2;SLC14A2;CALM1;DNM2;ACTB |
nitric-oxide synthase inhibitor activity | |
contributes_to nitric-oxide synthase inhibitor activity | |
protein binding | DVL2;WHRN;BDKRB1;CDK20;TDRD1;FZD8;RECQL;KLRC4-KLRK1;COX5A |
protein phosphatase 2B binding | AKAP5;BAD;MYOZ2;PPP3CB;SLC9A1;ATP2B4;AKAP1;SOD1 |
scaffold protein binding | NLGN1;DLG4;SHANK1;NOS1;HOMER1;PANX1;CIT;VIM;CACNA1H |
contributes_to sodium channel regulator activity | SNTA1;ATP2B4 |
ATP2B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B4.
Nos1; CALCA; STIM1; Nos1; 15-deoxy-delta(12,14; EGFR; 1C; CDK7; YWHAE
Research Area
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Customer Reviews (3)
Write a reviewBecause it is not easy to be contaminated, it is stored again.
The protein's activity is truly remarkable, able to catalyze reactions even under extreme conditions.
ATP2B4's stability is truly remarkable, able to maintain its activity even under extreme conditions.
Q&As (6)
Ask a questionATP2B4 gene mutation may be related to some hereditary diseases such as acoustic neuroma and lung cancer.
This is a calcium transporter, which is mainly responsible for transporting intracellular calcium to the outside of the cell, thereby maintaining the intracellular and extracellular calcium balance.
There are several differences in protein structure and function between ATP2B4 and other atpase B family members, mainly depending on how they are expressed and regulated in different tissues and cells.
The production pathway of ATP2B4 protein mainly includes multiple biological processes such as gene transcription, RNA splicing, protein translation and subsequent modification.
The expression of ATP2B4 may be related to the occurrence and development of diabetes, obesity, cardiovascular disease, liver disease and other diseases.
The relationship between ATP2B4 and cardiovascular disease may be achieved through several mechanisms such as regulating cardiomyocyte contraction and vascular smooth muscle cell contraction.
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