ATP2B4

  • Official Full Name

    ATPase, Ca++ transporting, plasma membrane 4

  • Overview

    Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene.
  • Synonyms

    ATP2B4; ATPase, Ca++ transporting, plasma membrane 4; plasma membrane calcium-transporting ATPase 4; AT2B4_HUMAN; ATP2B2; ATPase Ca++ transporting plasma membrane 4; Cation transporting ATPase; DKFZp686G08106; DKFZp686M088; Matrix remodelling associated 1; Matrix remodelling associated protein 1; Matrix-remodeling-associated protein 1; MXRA 1; MXRA1; OTTHUMP00000034088; OTTHUMP00000034089; Plasma membrane calcium ATPase 4; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Plasma membrane calcium transporting ATPase 4; PMCA 4; PMCA4; PMCA4b; PMCA4x; Sarcolemmal calcium pump; ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP2B4-27795TH Recombinant Human ATP2B4 Wheat Germ N/A 92 amino acids
Human ATP2B4-973H Recombinant Human ATP2B4 protein, GST-tagged Wheat Germ GST
Human ATP2B4-301117H Recombinant Human ATP2B4 protein, GST-tagged E.coli GST Gly281-Pro345
Human ATP2B4-6544H Recombinant Human ATP2B4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP2B4-2945H Recombinant Human ATP2B4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP2B4-2588H Recombinant Human ATP2B4 protein, His-tagged E.coli His 281-345 aa
Mouse Atp2b4-1767M Recombinant Mouse Atp2b4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ATP2B4-864R Recombinant Rat ATP2B4 Protein Mammalian Cell His
Rat ATP2B4-520R Recombinant Rat ATP2B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP2B4-865R Recombinant Rat ATP2B4 Protein, His-tagged E.coli His Pro1018~Val1203
Rat ATP2B4-520R-B Recombinant Rat ATP2B4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP2B4-451R Recombinant Rhesus monkey ATP2B4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP2B4-280R-B Recombinant Rhesus Macaque ATP2B4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP2B4-280R Recombinant Rhesus Macaque ATP2B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ATP2B4-4741Z Recombinant Zebrafish ATP2B4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP2B4 involved in several pathways and played different roles in them. We selected most pathways ATP2B4 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayCHRM5A;GRPR;ADRB3B;SPHK1;GRM1;MYLK4;ADRB3A;ORAI2;SLC8A2B
cGMP-PKG signaling pathwayINS;ATP1A3;LOC100328615;CALML3;ROCK2;SRF;GUCY1A3;GNAI2;IRS2
cAMP signaling pathwayMAPK1;VAV3;FXYD1;ORAI1;FFAR2;CAMK2D;AMH;MAPK10;GLP1R
Adrenergic signaling in cardiomyocytesCREB3L3A;PPP1CB;ATP1A2;PIK3R2;CACNA1D;ATP1A3B;GNAI3;CACNB2A;SCN1BA
Salivary secretionATP2B4;AQP5;PRKACG;PRKCB;PRKACA;BEST2;ITPR1;MUC7;LYZ1
Pancreatic secretionITPR3;PNLIP;PLCB4;CPA1;SCTR;PLA2G5;PLA2G10;PLA2G2D;PRKCA

ATP2B4 has several biochemical functions, for example, ATP binding, PDZ domain binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B4 itself. We selected most functions ATP2B4 had, and list some proteins which have the same functions with ATP2B4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCDK10;NLRX1;UBE2F;TRIO;MYO1EB;MAT2A;EPHA3;CAMKVB;CDC7
PDZ domain bindingGRASP;ATP2B2;ATP2B3B;FZD2;USHBP1;CXADR;DLG3;DOCK4;ATP2B1
calcium-transporting ATPase activityATP2A2A;ATP2A3;ATP2C1;ATP2B3B;ATP2A1;ATP2A2;ATP2B1B;ATP2C2;ATP2B3A
calmodulin bindingEWSR1;MYLK;GEM;MYO7A;ADD3;ATP2B4;OBSCN;NOS2;SLC8A1
metal ion bindingKLK4;ZNF843;ZFPM2;ZFP367;LNPB;ZDHHC23B;SIAH1A;CADPS;CHN2
nitric-oxide synthase bindingSLC14A2;DNM3;CAMK2D;CDH2;NOS1AP;CALM1;DNM2;DMD;SNTA1
nitric-oxide synthase inhibitor activity
contributes_to nitric-oxide synthase inhibitor activity
protein bindingNPC2;TNFSF13B;SNAP25;SMARCC1;ANGPTL4;BTN3A1;SPHK1;TBC1D16;ARHGEF2
protein phosphatase 2B bindingBAD;ATP2B4;AKAP5;PPP3CB;MYOZ2;SOD1;SLC9A1;AKAP1
scaffold protein bindingATP2B4;TREM1;KCNH2;MAP2K2;NLGN4Y;DLG4;CHUK;CACNA1G;DSP
contributes_to sodium channel regulator activityATP2B4;SNTA1

ATP2B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B4.

Nos1; CALCA; STIM1; Nos1; 15-deoxy-delta(12,14; EGFR; 1C; CDK7; YWHAE

Research Area

Related articles

Brandenburger, T; Strehler, EE; et al. Switch of PMCA4 Splice Variants in Bovine Epididymis Results in Altered Isoform Expression during Functional Sperm Maturation. JOURNAL OF BIOLOGICAL CHEMISTRY 286:7938-7946(2011).
Mangialavori, I; Giraldo, AMV; et al. A New Conformation in Sarcoplasmic Reticulum Calcium Pump and Plasma Membrane Ca2+ Pumps Revealed by a Photoactivatable Phospholipidic Probe. JOURNAL OF BIOLOGICAL CHEMISTRY 284:4823-4828(2009).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
06/10/2021

    Because it is not easy to be contaminated, it is stored again.

    10/13/2020

      The protein's activity is truly remarkable, able to catalyze reactions even under extreme conditions.

      05/14/2020

        ATP2B4's stability is truly remarkable, able to maintain its activity even under extreme conditions.

        Q&As (6)

        Ask a question
        Are mutations in ATP2B4 associated with rare genetic diseases? 08/27/2022

        ATP2B4 gene mutation may be related to some hereditary diseases such as acoustic neuroma and lung cancer.

        What is the biological function of ATP2B4? 08/02/2021

        This is a calcium transporter, which is mainly responsible for transporting intracellular calcium to the outside of the cell, thereby maintaining the intracellular and extracellular calcium balance.

        How does the protein structure and function of ATP2B4 differ from other atpase B family members? 04/30/2021

        There are several differences in protein structure and function between ATP2B4 and other atpase B family members, mainly depending on how they are expressed and regulated in different tissues and cells.

        What are the pathways of ATP2B4 protein production? 01/07/2021

        The production pathway of ATP2B4 protein mainly includes multiple biological processes such as gene transcription, RNA splicing, protein translation and subsequent modification.

        What diseases are associated with ATP2B4 expression? 11/27/2020

        The expression of ATP2B4 may be related to the occurrence and development of diabetes, obesity, cardiovascular disease, liver disease and other diseases.

        Is ATP2B4 associated with cardiovascular disease? 09/01/2020

        The relationship between ATP2B4 and cardiovascular disease may be achieved through several mechanisms such as regulating cardiomyocyte contraction and vascular smooth muscle cell contraction.

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