ATP5E
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Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
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Background
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13. Read-through transcripts that include exons from this gene are expressed from the upstream gene SLMO2. -
Synonyms
ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit; ATP synthase subunit epsilon, mitochondrial; F(0)F(1)-ATPase; mitochondrial ATPase; H(+)-transporting two-sector ATPase; mitochondrial ATP synthase epsilon chain; ATPE; MC5DN;
- Involved Pathway
- Protein Function
- Interacting Protein
ATP5E involved in several pathways and played different roles in them. We selected most pathways ATP5E participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | NDUFB11;NDUFS8B;UQCR11;COX6B2;ATP5H;ATP5G1;ATP6V1BA;ATP6V0E;ATP6V1D |
| Metabolic pathways | MGAT4A;CYP26A1;CDS2;GLS2;DNMT3AA;PCYT2;NDUFC2-KCTD14;ITPKB;CYP2B6 |
| Alzheimers disease | LPL;TNFRSF1A;NCSTN;GRIN2B;ADAM10;NDUFB6;CDK5R1;HSD17B10;FAS |
| Parkinsons disease | COX6A2;MT-ND4;NDUFS6;PARK2;NDUFA4L2;LRRK2;CASP9;Atp5g2;ATP5H |
| Huntingtons disease | NDUFS1;SLC25A31;Casp3;IFT57;NDUFS5;NDUFA6;PLCB4;POLR2H;PPARGC1A |
ATP5E has several biochemical functions, for example, contributes_to ATPase activity, proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5E itself. We selected most functions ATP5E had, and list some proteins which have the same functions with ATP5E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ATPase activity | ATP5A1;ATP5C1;ABCG8;ABCA7;RUVBL2;ATP6V1H;MSH2;ATP5D;MSH6 |
| proton-transporting ATP synthase activity, rotational mechanism | ATP5E;ATP6AP1;ATP6V0C;ATP5B;ATP5A1;ATP6AP1B;ATP5C1;ATP5O |
| proton-transporting ATPase activity, rotational mechanism | ATP6V0E;ATP6V0E1;ATP6V0CB;ATP5C1;ATP5B;ATP6V1AA;ATP6V1C1;ATP5A1;ATP6V0B |
| transmembrane transporter activity | ATP5C1;ATP5E;SLC22A23;SLC2A9L1;RALBP1;ATP5H;SV2C;SLC22A1;ATP5O |
ATP5E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5E here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5E.
CYP17A1; BLK; Atp5a1; SLC36A1; SLC38A2; SLC38A1
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