Recombinant Human ATP5E, GST-tagged
|Product Overview :||Recombinant Human ATP5E protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.|
- Gene Information
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|Description :||This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13. Read-through transcripts that include exons from this gene are expressed from the upstream gene SLMO2.|
|Protein length :||1-51a.a.|
|Storage :||The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.|
|Storage Buffer :||1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.|
|Gene Name :||ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [ Homo sapiens ]|
|Official Symbol :||ATP5E|
|Synonyms :||ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit; ATP synthase subunit epsilon, mitochondrial; F(0)F(1)-ATPase; mitochondrial ATPase; H(+)-transporting two-sector ATPase; mitochondrial ATP synthase epsilon chain; ATPE; MC5DN3; MGC104243;|
|Gene ID :||514|
|mRNA Refseq :||NM_006886|
|Protein Refseq :||NP_008817|
|UniProt ID :||P56381|
|Chromosome Location :||20q13.3|
|Pathway :||Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Electron Transport Chain, organism-specific biosystem; F-type ATPase, eukaryotes, organism-specific biosystem; Formation of ATP by chemiosmotic coupling, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem;|
|Function :||contributes_to ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrolase activity; proton-transporting ATPase activity, rotational mechanism; transmembrane transporter activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
ATP5E may play a role in tumor cell metabolism and energy supply.
Yes, ATP5E gene mutations are associated with certain neurological disorders such as Parkinson's disease, spinocerebellar ataxia, etc.
ATP5E protein may be associated with the occurrence and progression of metabolic diseases such as obesity and diabetes.
Gene mutation may lead to abnormal protein structure or function, which in turn affects the physiological function of the protein and is associated with specific diseases.
ATP5E expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.
It is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.
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The manufacturer's products are derived from sustainable sources, ensuring minimal impact on the environment and local communities. -
This manufacturer's reputation for excellence in protein production is well deserved, with a focus on customer satisfaction and reliable delivery. -
Because proteins have short half-lives, they can be delivered more precisely and in a controlled manner, ensuring optimal therapeutic effects. -
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