ATP6V1B2

  • Official Full Name

    ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.
  • Synonyms

    ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; ATP6B2, ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide, 56/58kD, isoform 2 , ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2 , VPP3; V-type proton ATPase subunit B, brain isoform; HO57; VATB; Vma2; ATP6B1B2; ATP6B2; ATP6V1 B2; ATP6V1B 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2; ATPase H+ transporting, lysosomal (vacuolar proton pump) beta polypeptide 56/58kD isoform 2; ATPase, H+ transporting, lysosomal V1 subunit B2; Endomembrane proton pump 58 kDa subunit; H+ transporting two sector ATPase; HO 57; V ATPase B2 subunit; V ATPase subunit B 2; V type proton ATPase subunit B, brain isoform; Vacuolar ATP synthase subunit B brain isoform; Vacuolar H+ ATPase 56000 subunit; Vacuolar H+ATPase B2; Vacuolar proton pump subunit B 2; VAT B2; VATB 2; VATB2; Vma 2; VPP 3; VPP3; OTTHUMP00000161707; V-ATPase B2 subunit; V-ATPase subunit B 2; H+ transporting two-sector ATPase; vacuolar H+-ATPase 56,000 subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V1B2-1002H Recombinant Human ATP6V1B2 protein, GST-tagged Wheat Germ GST
Human ATP6V1B2-10042H Recombinant Human ATP, His-tagged E.coli His 162-511a.a.
Human ATP6V1B2-8583HCL Recombinant Human ATP6V1B2 293 Cell Lysate HEK293 N/A
Human ATP6V1B2-2300H Recombinant Human ATP6V1B2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP6V1B2-1511HF Recombinant Full Length Human ATP6V1B2 Protein, GST-tagged In Vitro Cell Free System GST 511 amino acids
Human ATP6V1B2-1223HFL Recombinant Full Length Human ATP6V1B2 Protein, C-Flag-tagged Mammalian cells Flag
Human ATP6V1B2-406H Recombinant Human ATP6V1B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP6V1B2-406H-B Recombinant Human ATP6V1B2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ATP6V1B2-2160M Recombinant Mouse ATP6V1B2 Protein Mammalian Cell His
Mouse Atp6v1b2-671M Recombinant Mouse Atp6v1b2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ATP6V1B2-876M Recombinant Mouse ATP6V1B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ATP6V1B2-876M-B Recombinant Mouse ATP6V1B2 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V1B2-890R Recombinant Rat ATP6V1B2 Protein Mammalian Cell His
Rat ATP6V1B2-546R Recombinant Rat ATP6V1B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP6V1B2-546R-B Recombinant Rat ATP6V1B2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ATP6V1B2-9668Z Recombinant Zebrafish ATP6V1B2 Mammalian Cell His
Chicken ATP6V1B2-5562C Recombinant Chicken ATP6V1B2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP6V1B2 involved in several pathways and played different roles in them. We selected most pathways ATP6V1B2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationATP6V1E2;NDUFB5;COX7A1;MT-ATP6;ATP5F1;ATP6V0A1A;NDUFA8;UQCRFS1;NDUFB6
Metabolic pathwaysPOLA1;BCAT2;GUK1;C1GALT1C1;CHKA;POLR3D;ATP6V0E2;UGDH;TPH1
PhagosomeTLR2;ATP6V1C1B;HLA-DOA;TLR4BB;THBS1;Itgam&Itgb2;RAB5C;HLA-DQA2;TAP2
Synaptic vesicle cycleATP6V1B2;ATP6V0A2;UNC13A;RAB3A;STXBP1;STX3;CPLX4;SLC17A8;NSF
Collecting duct acid secretionCLCNKB;ATP6V0E2;SLC4A1;ATP6V1A;ATP6V0A4;ATP6V0A1;ATP4A;ATP6V1E1;ATP6V1B1
Vibrio cholerae infectionERO1L;ATP6V1G1;ATP6V1E2;ATP6V1B1;ATP6V0A1;TJP2;ATP6V0D2;PRKACA;ATP6V0A2
Epithelial cell signaling in Helicobacter pylori infectionMAPK8;MAPK11;NOD1;ADAM17;MAPK12;ATP6V0C;CXCL1;MAPK13;ATP6V1F
Rheumatoid arthritisCCL5;ATP6V0E;HLA-DRA;ATP6V1C2;HLA-DPB1;ATP6V0A4;ATP6V1B2;ATP6V1E1;HLA-DQB1

ATP6V1B2 has several biochemical functions, for example, ATP binding, hydrogen ion transmembrane transporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1B2 itself. We selected most functions ATP6V1B2 had, and list some proteins which have the same functions with ATP6V1B2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMOV10B.2;CLK2;RAF1A;RTEL1;EIF2AK4;PSMC6;SRC;DDX18;STK40
hydrogen ion transmembrane transporter activityATP5L;ATP5IB;SLC36A1;SLC36A2;ATP6V1C1A;ATP5H;ATP5G3A;ATP5G1;SLC46A1
protein bindingFKBP4;DPCD;MEMO1;SOCS5;LNPEP;TRPC6;RGS3;PLAC9;FAN1
proton-transporting ATPase activity, rotational mechanismATP6V1F;ATP6AP1;ATP6V1B2;TCIRG1;ATP6V0A1A;ATP6V1AA;ATP6V0A1B;ATP6V1C1;ATP6V0E

ATP6V1B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1B2.

TCF4; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; Ccdc9; ATP6AP2; A2M; FN1; PTPN1; Rab5c; Bmpr1a; ATP6V1A; Vps4b; RAB5C; RAB7A; RAB2A

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