cd1a

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cd1a

Official Full Name CD1a Molecule
Background This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Synonyms CD1A; CD1a molecule; R4; T6; CD1; FCB6; HTA1; Preferred Names; T-cell surface glycoprotein CD1a; Names; OTTHUMP00000018907; hTa1 thymocyte antigen; CD1A antigen, a polypeptide; cluster of differentiation 1 A; T-cell surface antigen T6/Leu-6; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a
    • Species :
    • Human
    • Rhesus
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rhesus CD1A-316R Recombinant Rhesus CD1A Protein, His-tagged HEK293 His
    Human CD1A-174HCL Recombinant Human CD1A lysate HEK293 N/A
    Human CD1A-24H Recombinant Human CD1A protein, His-tagged E.coli His
    Human CD1A-25H Recombinant Human CD1A protein, GST-tagged E.coli GST
    Human CD1A-26H Recombinant Human CD1A protein, His-tagged E.coli His
    Human CD1A-27866TH Recombinant Human CD1A protein, GST-tagged Wheat Germ GST
    Human CD1A-3042H Recombinant Human CD1A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD1A-367H Recombinant Human CD1A protein E.coli N/A
    Human CD1A-826H Recombinant Human CD1A Protein, Fc-tagged HEK293 Fc
    Human CDA076P Recombinant Human CD-1A E.coli N/A
    Rhesus Macaque CD1A-720R Recombinant Rhesus monkey CD1A Protein, His-tagged Mammalian Cell His

    cd1a involved in several pathways and played different roles in them. We selected most pathways cd1a participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hematopoietic cell lineage EPO; CD34; CR1; EPOR; ITGA3; Fcer2a; IL11; IL1B; HLA-DRB4; HLA-DRB3

    cd1a has several biochemical functions, for example, beta-2-microglobulin binding, endogenous lipid antigen binding, exogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cd1a itself. We selected most functions cd1a had, and list some proteins which have the same functions with cd1a. You can find most of the proteins on our site.

    Function Related Protein
    beta-2-microglobulin binding HLA-A; CD1d1; H2-Q10; CD1B; CD1E; HFE; CD1A; CD1C; HLA-E; CD1D2
    endogenous lipid antigen binding CD1E; CD1d1; CD1C; CD1D2; CD1A; CD1D; CD1B
    exogenous lipid antigen binding CD1E; CD1B; CD1d1; CD1D2; CD1A; CD1D; CD1C
    lipopeptide binding CD1A; CD1E; CD1C; TLR6; CD1B; CD1d1; CD1D2; CD1D
    protein binding GYG1; C2orf28; TACR2; PRPF6; TNFRSF6B; C22orf29; TRAF3IP2; NUP205; WSB1; TEKT5

    cd1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd1a here. Most of them are supplied by our site. Hope this information will be useful for your research of cd1a.

    B2M; DGAT1; UBTD1; KCTD5

    Raheja, A; Sinha, S; et al. A Case of Giant Intracranial Tuberculoma in an Infant: Clinical and Radiologic Pitfalls. JOURNAL OF CHILD NEUROLOGY 30:364-367(2015).
    Birkinshaw, RW; Pellicci, DG; et al. alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands. NATURE IMMUNOLOGY 16:258-U215(2015).

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