CD1A

  • Official Full Name

    CD1a Molecule

  • Overview

    This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
  • Synonyms

    CD1A; CD1a molecule; R4; T6; CD1; FCB6; HTA1; Preferred Names; T-cell surface glycoprotein CD1a; Names; OTTHUMP00000018907; hTa1 thymocyte antigen; CD1A antigen, a polypeptide; cluster of differentiation 1 A; T-cell surface antigen T6/Leu-6; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Rhesus
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD1A-24H Recombinant Human CD1A protein, His-tagged E.coli His
Human CD1A-27866TH Recombinant Human CD1A protein, GST-tagged Wheat Germ GST
Human CD1A-25H Recombinant Human CD1A protein, GST-tagged E.coli GST
Human CD1A-367H Recombinant Human CD1A protein E.coli N/A
Human CD1A-826H Recombinant Human CD1A Protein, Fc-tagged HEK293 Fc
Human CD1A-26H Recombinant Human CD1A protein, His-tagged E.coli His
Human CD1A-174HCL Recombinant Human CD1A lysate HEK293 N/A
Human CD1A-163H Recombinant Human CD1A Protein, C-His-tagged E.coli C-His
Human CD1A-151H Recombinant Human CD1A Protein, His-tagged Human Cells His
Human CD1A-3042H Recombinant Human CD1A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD1A-27H Recombinant Human CD1A protein, His-tagged E.coli His 1-327 aa
Human CD1a-533M CD1a protein-coupled magnetic MicroBeads
Human CDA076P Recombinant Human CD-1A E.coli N/A
Human CD1A-656H Recombinant Human CD1A Protein, His-tagged E.coli N-His Asn17-Val300
Human CD1A-5276H Recombinant Human CD1A Protein (Met1-Val300), C-His tagged Mammalian cells C-His Met1-Val300
Human CD1A-152H Recombinant Human CD1A protein, His-tagged HEK293 His Asp19-Val300
Human CD1A-1455H Recombinant Human CD1A Protein (Leu21-Val300), N-His tagged E.coli N-His Leu21-Val300
Homo sapiens (Human) RFL29630HF Recombinant Full Length Human T-Cell Surface Glycoprotein Cd1A(Cd1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-327)
Rhesus CD1A-316R Recombinant Rhesus CD1A Protein, His-tagged HEK293 His Met1-Ser299
Rhesus Macaque CD1A-720R Recombinant Rhesus monkey CD1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD1A-547R-B Recombinant Rhesus Macaque CD1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD1A-547R Recombinant Rhesus Macaque CD1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD1A involved in several pathways and played different roles in them. We selected most pathways CD1A participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageFCGR1;GP5;FCGR1A;GM13305;CSF1R;Fcer2a;HLA-DRB4;IL1R2;CD3E

CD1A has several biochemical functions, for example, beta-2-microglobulin binding, endogenous lipid antigen binding, exogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD1A itself. We selected most functions CD1A had, and list some proteins which have the same functions with CD1A. You can find most of the proteins on our site.

Function Related Protein
beta-2-microglobulin bindingFCGRT;CD1D2;CD1C;HLA-A;CD1d1;HFE;CD1A;HLA-E;CD1B
endogenous lipid antigen bindingCD1D2;CD1D;CD1B;CD1C;CD1d1;CD1A;CD1E
exogenous lipid antigen bindingCD1B;CD1D;CD1C;CD1E;CD1A;CD1d1;CD1D2
lipopeptide bindingCD1E;CD1d1;CD1C;TLR6;CD1B;CD1D2;CD1D;CD1A
protein bindingSLC14A2;MYCBP;KLRG1;TCEAL5;C20orf195;C17orf62;IFITM3;DHDDS;KRT16

CD1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CD1A.

B2M; DGAT1; UBTD1; KCTD5

Research Area

Related articles

Raheja, A; Sinha, S; et al. A Case of Giant Intracranial Tuberculoma in an Infant: Clinical and Radiologic Pitfalls. JOURNAL OF CHILD NEUROLOGY 30:364-367(2015).
Birkinshaw, RW; Pellicci, DG; et al. alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands. NATURE IMMUNOLOGY 16:258-U215(2015).
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