• Official Full Name

    CD1e molecule

  • Overview

    This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. T-cell surface glycoprotein CD1e, membrane-associated?is aprotein?that in humans is encoded by the?CD1E?gene.
  • Synonyms

    CD1E; CD1e molecule; CD1e antigen , CD1E antigen, e polypeptide; T-cell surface glycoprotein CD1e, membrane-associated; CD_antigen=CD1e; CD1A; CD1e antigen; CD1E antigen, e polypeptide; Differentiation antigen CD1-alpha-3; hCD1e; Leukocyte differentiation antigen; R2; R2G1; sCD1e; T-cell surface glycoprotein CD1e, soluble; thymocyte antigen CD1E;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cavia porcellus (Guinea pig)
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Human Cells
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD1E-5113H Recombinant Human CD1E, His-tagged E.coli His
Human CD1E-512H Recombinant Human CD1e molecule, His-tagged E.coli His
Human CD1E-7681HCL Recombinant Human CD1E 293 Cell Lysate HEK293 N/A
Human CD1E-0917H Recombinant Human CD1E Protein (Met39-Ala276), N-His tagged E.coli N-His Met39-Ala276
Human CD1E-151H Recombinant Human CD1E Protein, His-tagged Human Cells His
Human CD1E-167H Recombinant Human CD1E Protein, C-His-tagged E.coli C-His
Cavia porcellus (Guinea pig) RFL29791CF Recombinant Full Length Guinea Pig T-Cell Surface Glycoprotein Cd1E, Membrane-Associated(Cd1E) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (34-390)
Cynomolgus CD1E & B2M-197C Recombinant Cynomolgus CD1E & B2M protein, His-tagged HEK293 His Glu32-Gly303 & Met1-Met119
Cynomolgus Monkey CD1E & B2M-001CCL Recombinant Cynomolgus CD1E & B2M cell lysate Human Cell N/A
Rhesus Macaque CD1E-724R Recombinant Rhesus monkey CD1E Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD1E-551R Recombinant Rhesus Macaque CD1E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CD1E-551R-B Recombinant Rhesus Macaque CD1E Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD1E involved in several pathways and played different roles in them. We selected most pathways CD1E participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD1E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageFCGR1A;CD1D2;ITGA4;CD3D;CD2;GM2002;FLT3;IL4;TFRC

CD1E has several biochemical functions, for example, beta-2-microglobulin binding, endogenous lipid antigen binding, exogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD1E itself. We selected most functions CD1E had, and list some proteins which have the same functions with CD1E. You can find most of the proteins on our site.

Function Related Protein
beta-2-microglobulin bindingCD1C;CD1B;CD1E;CD1D2;HFE;HLA-A;HLA-E;CD1A;H2-Q10
endogenous lipid antigen bindingCD1D2;CD1d1;CD1E;CD1C;CD1A;CD1D;CD1B
exogenous lipid antigen bindingCD1C;CD1B;CD1d1;CD1D;CD1E;CD1A;CD1D2
lipopeptide bindingCD1C;CD1E;CD1D2;CD1A;CD1B;TLR6;CD1d1;CD1D

CD1E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD1E here. Most of them are supplied by our site. Hope this information will be useful for your research of CD1E.

Research Area

Related articles

Wu, LY; Zhou, Y; et al. The effect of TNF-alpha, Fc gamma R and CD1 polymorphisms on Guillain-Barre syndrome risk: Evidences from a Meta-Analysis. JOURNAL OF NEUROIMMUNOLOGY 243:18-24(2012).
Vlam, L; Cats, EA; et al. Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 16:175-179(2011).
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