CD200R1

  • Official Full Name

    CD200 receptor 1

  • Overview

    This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may contr
  • Synonyms

    CD200R1; CD200 receptor 1; OX2R; MOX2R; CD200R; HCRTR2; Orexin receptor 2; OTTMUSP00000015932; OTTMUSP00000030764; antigen identified by monoclonal antibody MRC OX-2 receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Avi|Fc
  • C
  • His
  • DYKDDDDK
  • Fc
  • Fc Chimera
  • Avi
  • Fc|His
  • GST
  • hFc
  • HIgG
  • His (Fc)
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD200R1-417H Active Recombinant Human CD200R1, Fc Chimera Mammalian cells Fc Chimera
Human CD200R1-051H Active Recombinant Human CD200R1 protein, Fc-Avi-tagged, Biotinylated CHO cells Fc/Avi
Human CD200R1-3254H Active Recombinant Human CD200R1 protein, His&hFc-tagged HEK293 His&hFc
Human CD200R1-3202H Recombinant Human CD200R1, His tagged Human Cell His
Human CD200R1-27295TH Recombinant Human CD200R1, GST-tagged Wheat Germ GST
Human CD200R1-347H Recombinant Human CD200R1 Protein, Fc-tagged HEK293 Fc
Human CD200R1-2523HCL Recombinant Human CD200R1 cell lysate Human Cell N/A
Human CD200R1-0988H Recombinant Human CD200R1 Protein (Met1-Leu266), C-His tagged Mammalian cells C-His
Human CD200R1-3287H Recombinant Human CD200R1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD200R1-3057H Recombinant Human CD200R1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD200R1-348H Active Recombinant Human CD200R1 Protein, Fc-Avi-tagged, Biotinylated HEK293 Avi/Fc
Human CD200R1-01H Active Recombinant Human CD200R1 Protein, hIgG-His-Tagged Insect Cell HIgG/His
Human CD200R1-321H Recombinant Human CD200R1 Protein, His-tagged Human Cells His
Human CD200R1-172H Recombinant Human CD200R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD200R1-1010H Recombinant Human CD200R1 protein, His-tagged HEK293 His
Human CD200R1-495H Active Recombinant Human CD200R1 protein, hFc-tagged HEK293 hFc
Human CD200R1-172H-B Recombinant Human CD200R1 Protein Pre-coupled Magnetic Beads HEK293
Human CD200R1-322H Recombinant Human CD200R1 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CD200R1-55HF Recombinant Full Length Human CD200R1 Protein, GST-tagged In Vitro Cell Free System GST
Mouse Cd200r1-458M Active Recombinant Mouse Cd200r1, Fc Chimera Mammalian cells Fc Chimera
Mouse Cd200r1-3280M Active Recombinant Mouse Cd200r1 protein, His-tagged HEK293 His
Mouse Cd200r1-631M Recombinant Mouse Cd200r1, Fc-His tagged Human Cell Fc/His
Mouse CD200R1-2226MCL Recombinant Mouse CD200R1 cell lysate Human Cell N/A
Mouse Cd200r1-2054M Recombinant Mouse Cd200r1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Cd200r1-661M Recombinant Mouse Cd200r1 Protein, His-tagged E.coli N-His
Mouse Cd200r1-125M-B Recombinant Mouse Cd200r1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd200r1-125M Recombinant Mouse Cd200r1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CD200R1-1240R Recombinant Rat CD200R1 Protein Mammalian Cell His
Rat CD200R1-38R Recombinant Rat CD200R1 Protein, His-tagged HEK293 His
Rat CD200R1-898R Recombinant Rat CD200R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CD200R1-898R-B Recombinant Rat CD200R1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL9031BF Recombinant Full Length Bovine Cell Surface Glycoprotein Cd200 Receptor 1(Cd200R1) Protein, His-Tagged E.coli expression system His
Cynomolgus CD200R1-3483C Active Recombinant Cynomolgus CD200R1 Protein, His-tagged HEK293 His
Cynomolgus Monkey CD200R1-2483CCL Recombinant Cynomolgus CD200R1 cell lysate Human Cell N/A
Chicken CD200R1-3523C Recombinant Chicken CD200R1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD200R1 Related Articles

CD200R1 involved in several pathways and played different roles in them. We selected most pathways CD200R1 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD200R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemRNF220;ATG7;AP2M1;LRRC41;CLEC2H;ASB13;RASGRP1;CTSC;CLEC2D
Immune SystemTRIM68;KIF18A;IRF6;AGER;SIRPB1;RAET1E;TRIM2;HUWE1;UBE2U
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellCLEC2D;CD300LG;KLRB1A;AF251705;KLRF1;CD300LD;CD200R2;Siglece;MICA

CD200R1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD200R1 itself. We selected most functions CD200R1 had, and list some proteins which have the same functions with CD200R1. You can find most of the proteins on our site.

Function Related Protein
protein bindingNUP153;SDC2;LONRF3;PTGER4;PHAX;SIGLEC8;CCL5;GET4;TELO2

CD200R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD200R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD200R1.

CD200

Nicholls, SM; Copland, DA; et al. Local targeting of the CD200-CD200R axis does not promote corneal graft survival. EXPERIMENTAL EYE RESEARCH 130:1-8(2015).
Gorczynski, R; Yu, K; et al. Anti-CD200R2, Anti-IL-9, Anti-IL-35, or Anti-TGF-A Abolishes Increased Graft Survival and Treg Induction Induced in Cromolyn- Treated CD200R1KO. CD200tg Mice. TRANSPLANTATION 97:39-46(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
 Is CD200R1 a potential therapeutic target for immune-related disorders? 02/22/2023

Modulating CD200R1 signaling holds therapeutic potential for immune-related disorders. Enhancing CD200R1 signaling or agonizing CD200R1 with specific agonists could help dampen excessive immune responses, attenuate inflammation, and promote immune tolerance. Conversely, inhibiting CD200R1 signaling or blocking CD200-CD200R1 interaction may be beneficial in conditions where immune suppression is desired, such as cancer immunotherapy. However, further research is needed to develop safe and effective therapeutic strategies targeting CD200R1, taking into consideration the potential impact on immune cell functions and overall immune homeostasis.

Are there any disease associations with CD200R1 dysregulation? 07/28/2021

Dysregulation of CD200R1 signaling has been implicated in the pathogenesis of several diseases. Reduced CD200R1 expression or impaired CD200-CD200R1 interaction has been observed in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. This dysregulation can lead to excessive activation of immune cells and chronic inflammation. Furthermore, altered CD200R1 expression has been reported in neuroinflammatory conditions, such as Alzheimer's disease and Parkinson's disease. However, more studies are required to elucidate the specific roles of CD200R1 dysregulation in disease development and progression.

What is the cellular localization of CD200R1 protein in the body? 01/01/2021

 CD200R1 (CD200 receptor 1) is primarily expressed on the surface of various immune cells, including macrophages, dendritic cells, and mast cells. It is also found on some non-immune cells, such as neurons. The specific cellular localization of CD200R1 allows it to interact with its ligand, CD200, which is expressed on many cell types, including neurons, endothelial cells, and immune cells. This interaction plays a crucial role in regulating immune responses and maintaining immune homeostasis.

What is the role of CD200R1 in immune regulation and tolerance? 03/10/2020

CD200R1 plays a critical role in immune regulation and tolerance. The interaction between CD200R1 on immune cells and its ligand CD200 on target cells provides a potent inhibitory signal, suppressing immune cell activation and effector functions. This regulation helps prevent autoimmune responses and excessive inflammation. CD200R1 signaling inhibits the activation of immune cells, such as macrophages and dendritic cells, thereby reducing their pro-inflammatory cytokine production and antigen presentation capacity. Dysregulation of CD200R1 signaling has been associated with autoimmune diseases and neuroinflammatory disorders.

How is CD200R1 expression regulated in immune cells? 03/14/2019

 CD200R1 expression is regulated by various factors, including cytokines and transcriptional regulators. Pro-inflammatory cytokines, such as interferon-gamma, can downregulate CD200R1 expression on immune cells, whereas anti-inflammatory cytokines, such as interleukin-4, can upregulate its expression. Transcription factors, such as PU.1 and GATA-1, are involved in regulating CD200R1 gene expression. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can influence CD200R1 expression levels. Further research is needed to fully understand the complex regulatory mechanisms governing CD200R1 expression.

What are the signaling pathways activated upon CD200R1-CD200 interaction? 06/22/2018

CD200R1 engagement with its ligand CD200 triggers inhibitory signaling pathways, primarily mediated by immunoreceptor tyrosine-based inhibitory motifs (ITIMs) present in the CD200R1 cytoplasmic domain. Upon ligand binding, CD200R1 recruits and activates phosphatases, such as SHP-1 and SHP-2, which dephosphorylate downstream signaling molecules. This leads to the inhibition of various immune cell functions, including phagocytosis, cytokine production, and antigen presentation. The CD200R1-CD200 signaling axis is crucial for maintaining immune tolerance and preventing excessive immune activation.

What are the downstream signaling pathways activated by CD200R1? 07/15/2016

Upon binding of CD200 to CD200R1, several downstream signaling pathways are activated. One of the main pathways involves the recruitment and activation of Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2. These phosphatases inhibit signaling cascades initiated by immune receptors, including inhibitory signaling through the inhibitory receptor CD200R1 itself. Additionally, CD200R1 engagement can also lead to the modulation of PI3K-Akt and MAPK pathways, further influencing immune cell function and cytokine production.

Customer Reviews (3)

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Reviews
05/25/2020

    The convenience it offers saves a considerable amount of time and effort.

    04/10/2020

      The robustness of this reagent guarantees consistent results, regardless of the number of experiment replications.

      06/07/2016

        Purity personified, unlocking the gates to triumphant experiments.

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