Recombinant Full Length Bovine Cell Surface Glycoprotein Cd200 Receptor 1(Cd200R1) Protein, His-Tagged

Cat.No. : RFL9031BF
Product Overview : Recombinant Full Length Bovine Cell surface glycoprotein CD200 receptor 1(CD200R1) Protein (A5D7V5) (27-355aa), fused to N-terminal His tag, was expressed in E. coli.
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Source : E.coli expression system
Species : Bos taurus (Bovine)
Tag : His
Form : Lyophilized powder
Protein length : Full Length of Mature Protein (27-355)
Purity : Greater than 90% as determined by SDS-PAGE.
Applications : SDS-PAGE
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Storage Buffer : Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Gene Name : CD200R1
Synonyms : CD200R1; CD200R; Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1
UniProt ID : A5D7V5
Gene Name : CD200R1
Synonyms : CD200R1; CD200R; Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1
UniProt ID : A5D7V5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (7)

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 Is CD200R1 a potential therapeutic target for immune-related disorders? 02/22/2023

Modulating CD200R1 signaling holds therapeutic potential for immune-related disorders. Enhancing CD200R1 signaling or agonizing CD200R1 with specific agonists could help dampen excessive immune responses, attenuate inflammation, and promote immune tolerance. Conversely, inhibiting CD200R1 signaling or blocking CD200-CD200R1 interaction may be beneficial in conditions where immune suppression is desired, such as cancer immunotherapy. However, further research is needed to develop safe and effective therapeutic strategies targeting CD200R1, taking into consideration the potential impact on immune cell functions and overall immune homeostasis.

Are there any disease associations with CD200R1 dysregulation? 07/28/2021

Dysregulation of CD200R1 signaling has been implicated in the pathogenesis of several diseases. Reduced CD200R1 expression or impaired CD200-CD200R1 interaction has been observed in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. This dysregulation can lead to excessive activation of immune cells and chronic inflammation. Furthermore, altered CD200R1 expression has been reported in neuroinflammatory conditions, such as Alzheimer's disease and Parkinson's disease. However, more studies are required to elucidate the specific roles of CD200R1 dysregulation in disease development and progression.

What is the cellular localization of CD200R1 protein in the body? 01/01/2021

 CD200R1 (CD200 receptor 1) is primarily expressed on the surface of various immune cells, including macrophages, dendritic cells, and mast cells. It is also found on some non-immune cells, such as neurons. The specific cellular localization of CD200R1 allows it to interact with its ligand, CD200, which is expressed on many cell types, including neurons, endothelial cells, and immune cells. This interaction plays a crucial role in regulating immune responses and maintaining immune homeostasis.

What is the role of CD200R1 in immune regulation and tolerance? 03/10/2020

CD200R1 plays a critical role in immune regulation and tolerance. The interaction between CD200R1 on immune cells and its ligand CD200 on target cells provides a potent inhibitory signal, suppressing immune cell activation and effector functions. This regulation helps prevent autoimmune responses and excessive inflammation. CD200R1 signaling inhibits the activation of immune cells, such as macrophages and dendritic cells, thereby reducing their pro-inflammatory cytokine production and antigen presentation capacity. Dysregulation of CD200R1 signaling has been associated with autoimmune diseases and neuroinflammatory disorders.

How is CD200R1 expression regulated in immune cells? 03/14/2019

 CD200R1 expression is regulated by various factors, including cytokines and transcriptional regulators. Pro-inflammatory cytokines, such as interferon-gamma, can downregulate CD200R1 expression on immune cells, whereas anti-inflammatory cytokines, such as interleukin-4, can upregulate its expression. Transcription factors, such as PU.1 and GATA-1, are involved in regulating CD200R1 gene expression. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can influence CD200R1 expression levels. Further research is needed to fully understand the complex regulatory mechanisms governing CD200R1 expression.

What are the signaling pathways activated upon CD200R1-CD200 interaction? 06/22/2018

CD200R1 engagement with its ligand CD200 triggers inhibitory signaling pathways, primarily mediated by immunoreceptor tyrosine-based inhibitory motifs (ITIMs) present in the CD200R1 cytoplasmic domain. Upon ligand binding, CD200R1 recruits and activates phosphatases, such as SHP-1 and SHP-2, which dephosphorylate downstream signaling molecules. This leads to the inhibition of various immune cell functions, including phagocytosis, cytokine production, and antigen presentation. The CD200R1-CD200 signaling axis is crucial for maintaining immune tolerance and preventing excessive immune activation.

What are the downstream signaling pathways activated by CD200R1? 07/15/2016

Upon binding of CD200 to CD200R1, several downstream signaling pathways are activated. One of the main pathways involves the recruitment and activation of Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2. These phosphatases inhibit signaling cascades initiated by immune receptors, including inhibitory signaling through the inhibitory receptor CD200R1 itself. Additionally, CD200R1 engagement can also lead to the modulation of PI3K-Akt and MAPK pathways, further influencing immune cell function and cytokine production.

Customer Reviews (3)

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    The convenience it offers saves a considerable amount of time and effort.


      The robustness of this reagent guarantees consistent results, regardless of the number of experiment replications.


        Purity personified, unlocking the gates to triumphant experiments.

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