CEP57

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CEP57

Official Full Name centrosomal protein 57kDa
Background This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms CEP57; centrosomal protein 57kDa; centrosomal protein of 57 kDa; KIAA0092; Translokin; TSP57; Cep57 protein; FGF2 interacting protein; PIG8; Proliferation inducing protein 8; Testis specific protein 57; OTTHUMP00000236690; OTTHUMP00000236691; OTTHUMP00000236698; FGF2-interacting protein; testis-specific protein 57; proliferation-inducing protein 8; MVA2
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CEP57-1136H Recombinant Human CEP57 Protein, GST-Tagged Wheat Germ GST
    Human CEP57-256H Recombinant Human CEP57, GST-tagged E.coli GST
    Human CEP57-3207H Recombinant Human CEP57 Protein, GST/His-tagged E.coli GST/His
    Human CEP57-7572HCL Recombinant Human CEP57 293 Cell Lysate HEK293 N/A
    Mouse CEP57-3309M Recombinant Mouse CEP57 Protein Mammalian Cell His
    Rat CEP57-1343R Recombinant Rat CEP57 Protein Mammalian Cell His
    Zebrafish CEP57-5154Z Recombinant Zebrafish CEP57 Mammalian Cell His

    CEP57 involved in several pathways and played different roles in them. We selected most pathways CEP57 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEP57 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Anchoring of the basal body to the plasma membrane DCTN1; CSNK1E; DYNC1I2; CKAP5; CEP63; CLASP1; TUBB4B; MARK4; CDK5RAP2; NPHP1
    Assembly of the primary cilium CCDC41; CEP290; FLR; EXOC3; IFT81; TTC8; TCTN3; ARL3; ARF4; TCTN1
    Cell Cycle MAU2; NCAPG; RAD21A; GADD45A; RBL2; DYNC1I2; TGFB1; NDEL1A; CDK5RAP2; CHEK1
    Cell Cycle, Mitotic LIN52; CTDNEP1A; ANKLE2; NCAPD2; ODF2B; HIST3H2BB; NUPL2; ARPP19; NIPBLB; CENPP
    Centrosome maturation CLASP1A; NEDD1; OFD1; NUMA1; TUBB4A; CETN2; CKAP5; CP110; PCM1; SDCCAG8
    G2/M Transition MAPRE1; DCTN3; MAPRE1B; LIN9; LIN37; TUBGCP3; CEP152; CLASP1; DCTN2; TUBG2
    Loss of Nlp from mitotic centrosomes CCP110; NEDD1; CLASP1A; DCTN1A; CKAP5; SDCCAG8; CEP76; CP110; CEP57; CEP78
    Loss of proteins required for interphase microtubule organizationfrom the centrosome CEP152; CEP70; HAUS2; DCTN1A; ODF2B; SDCCAG8; SSNA1; MAPRE1B; CKAP5; CEP164

    CEP57 has several biochemical functions, for example, fibroblast growth factor binding, gamma-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CEP57 itself. We selected most functions CEP57 had, and list some proteins which have the same functions with CEP57. You can find most of the proteins on our site.

    Function Related Protein
    fibroblast growth factor binding Api5; THBS1; FGFBP1; TGFBR3; KLB; FGFR1; GLG1B; RPS19; FGFBP3; PTPRZ1
    gamma-tubulin binding LYN; TUBGCP3; TUBGCP5; RAD51D; RAB11FIP5; BLOC1S2A; NDRG1; DIXDC1; CEP57L1; NDN
    microtubule binding WDR43; GAPDH; KIF27; DPYSL2B; EML2; CEP350; MAPRE3; PRC1; KIF3CB; MTAP1B
    protein binding ASNA1; TRAPPC5; CIB4; IMMT; CCR3; NDE1; KRTAP10-8; HSPA1B; CSF3R; CCER1
    protein homodimerization activity CIDEA; DGAT2; ADD2; LSM1; TCF3B; FGFR1OP2; SYT10; SDCBP; TARBP2; PDZD7

    CEP57 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEP57 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEP57.

    RALBP1; GCC1; KRT13; CTAGE5; KRT15; KRT31

    de Sousa, JT; Milan, M; et al. A Microarray-Based Analysis of Gametogenesis in Two Portuguese Populations of the European Clam Ruditapes decussatus. PLOS ONE 9:-(2014).
    Pinson, L; Mannini, L; et al. CEP57 Mutation in a Girl With Mosaic Variegated Aneuploidy Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164:177-181(2014).

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