Recombinant Human CEP57 Protein, GST-Tagged

• Cat.No.: CEP57-1136H
• Product Overview: Human CEP57 full-length ORF (NP_055494.2, 1 a.a. - 500 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 80.63 kDa
• AA Sequence: MAAASVSAASGSHLSNSFAEPSRSN GSMVRHSSSPYVVYPSDKPFLNSDL RRSPSKPTLAYPESNSRAIFSALKN LQDKIRRLELERIQAEESVKTLSRE TIEYKKVLDEQIQERENSKNEESKH NQELTSQLLAAENKCNLLEKQLEYM RNMIKHAEMERTSVLEKQVSLERER QHDQTHVQSQLEKLDLLEQEYNKLT TMQALAEKKMQELEAKLHEEEQERK RMQAKAAELQTGLETNRLIFEDKAT PCVPNARRIKKKKSKPPEKKSSRNY FGAQPHYRLCLGDMPFVAGKSTSPS HAVVANVQLVLHLMKQHSKALCNDR VINSIPLAKQVSSRGGKSKKLSVTP PSSNGINEELSEVLQTLQDEFGQMS FDHQQLAKLIQESPTVELKDKLECE LEALVGRMEAKANQITKVRKYQAQL EKQKLEKQKKELKATKKTLDEERNS SSRSGITGTTNKKDFMKLRPGEKRR KNLQLLKDMQSIQNSLQSSSLCWDY
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CEP57 centrosomal protein 57kDa [ Homo sapiens ]
• Official Symbol: CEP57
• Synonyms: CEP57; centrosomal protein 57kDa; centrosomal protein of 57 kDa; KIAA0092; Translokin; TSP57; translokin; FGF2-interacting protein; testis-specific protein 57; proliferation-inducing protein 8; MVA2; PIG8
• Gene ID: 9702
• mRNA Refseq: NM_001243776
• Protein Refseq: NP_001230705
• MIM: 607951
• UniProt ID: Q86XR8