Recombinant Human COL7A1 Protein, His-tagged
Cat.No. : | COL7A1-340H |
Product Overview : | Recombinant Human COL7A1(Pro190~Asp472) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 32.2kDa |
Protein length : | Pro190~Asp472 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | COL7A1 collagen, type VII, alpha 1 [ Homo sapiens ] |
Official Symbol : | COL7A1 |
Synonyms : | COL7A1; collagen, type VII, alpha 1; EBD1, EBDCT, EBR1, epidermolysis bullosa, dystrophic, dominant and recessive; collagen alpha-1(VII) chain; collagen VII; alpha 1 polypeptide; LC collagen; long-chain collagen; collagen VII, alpha-1 polypeptide; EBD1; EBR1; EBDCT; |
Gene ID : | 1294 |
mRNA Refseq : | NM_000094 |
Protein Refseq : | NP_000085 |
MIM : | 120120 |
UniProt ID : | Q02388 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (6)
Ask a questionIt can be diagnosed through genetic testing and skin biopsies. Genetic testing can detect mutations in the COL7A1 gene, while skin biopsies can observe abnormalities in skin structure.
There is currently no cure for the COL7A1 gene mutation, but there are treatments that can relieve symptoms, such as the use of special dressings, medication, and surgery.
The COL7A1 gene has been implicated in a variety of skin injuries, including burns, trauma, and surgical trauma. These injuries may lead to skin complications in DEB patients.
Mutations in the COL7A1 gene can cause structural abnormalities in the skin, making it fragile and prone to blisters and scarring, which can be accompanied by abnormalities in bones and internal organs.
Certain drugs may have efficacy or side effects on the COL7A1 gene mutation, for example, certain immunosuppressants used to treat other skin conditions may have adverse effects on the skin of DEB patients.
Although there is no conclusive evidence that diet can improve the COL7A1 gene mutation, maintaining a balanced diet with adequate protein, vitamins and minerals is beneficial for overall health.
Customer Reviews (3)
Write a reviewCOL7A1 is less polluting, safe and hygienic, and suitable for long-term use.
It is stable under different temperature and pH conditions.
Their service attitude is very good and always patient to answer our questions.
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