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Recombinant Human COL7A1 Protein, His-tagged

Cat.No. : COL7A1-340H
Product Overview : Recombinant Human COL7A1(Pro190~Asp472) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Description : This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 32.2kDa
Protein length : Pro190~Asp472
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : COL7A1 collagen, type VII, alpha 1 [ Homo sapiens ]
Official Symbol : COL7A1
Synonyms : COL7A1; collagen, type VII, alpha 1; EBD1, EBDCT, EBR1, epidermolysis bullosa, dystrophic, dominant and recessive; collagen alpha-1(VII) chain; collagen VII; alpha 1 polypeptide; LC collagen; long-chain collagen; collagen VII, alpha-1 polypeptide; EBD1; EBR1; EBDCT;
Gene ID : 1294
mRNA Refseq : NM_000094
Protein Refseq : NP_000085
MIM : 120120
UniProt ID : Q02388

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How is the COL7A1 gene mutation diagnosed? 08/15/2022

It can be diagnosed through genetic testing and skin biopsies. Genetic testing can detect mutations in the COL7A1 gene, while skin biopsies can observe abnormalities in skin structure.

What are the treatments for COL7A1 gene mutations? 08/26/2021

There is currently no cure for the COL7A1 gene mutation, but there are treatments that can relieve symptoms, such as the use of special dressings, medication, and surgery.

What types of skin damage is COL7A1 associated with? 03/22/2021

The COL7A1 gene has been implicated in a variety of skin injuries, including burns, trauma, and surgical trauma. These injuries may lead to skin complications in DEB patients.

What happens to a mutation in the COL7A1 gene? 10/30/2020

Mutations in the COL7A1 gene can cause structural abnormalities in the skin, making it fragile and prone to blisters and scarring, which can be accompanied by abnormalities in bones and internal organs.

Which drug responses are involved in the COL7A1 gene? 08/01/2020

Certain drugs may have efficacy or side effects on the COL7A1 gene mutation, for example, certain immunosuppressants used to treat other skin conditions may have adverse effects on the skin of DEB patients.

How to improve the COL7A1 gene mutation through diet? 02/12/2020

Although there is no conclusive evidence that diet can improve the COL7A1 gene mutation, maintaining a balanced diet with adequate protein, vitamins and minerals is beneficial for overall health.

Customer Reviews (3)

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Reviews
06/24/2023

    COL7A1 is less polluting, safe and hygienic, and suitable for long-term use.

    02/13/2022

      It is stable under different temperature and pH conditions.

      05/09/2020

        Their service attitude is very good and always patient to answer our questions.

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