• Official Full Name
  • cathepsin C
  • Background
  • The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CTSC; cathepsin C; PALS, PLS; dipeptidyl peptidase 1; DPP1; AI047818; CATC; Cathepsin J; CPPI; Dipeptidyl transferase; DPP I; DPPI; EC; HMS; JP; JPD; MGC126959; PALS; PLS; dipeptidyl peptidase I; dipeptidyl-peptidase I; DPP-I
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSC Protein, MYC/DDK-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTSC Protein, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSC, His tagged
Source (Host):NS0 cellsSpecies:Human
Product nameRecombinant Human CTSC, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSC protein, His-tagged
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ctsc, None tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CTSC Protein
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctsc protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CTSC Protein
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CTSC Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CTSC Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CTSC
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSC cell lysate

Ctsc Related Articles

Wang, XW; Liu, Y; et al. Long-term change of disease behavior in Papillon-Lefevre syndrome: Seven years follow-up. EUROPEAN JOURNAL OF MEDICAL GENETICS 58:184-187(2015).
Gregersen, VR; Gustavsson, F; et al. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. JOURNAL OF DAIRY SCIENCE 98:1261-1272(2015).