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Recombinant Human CTSC Protein, GST-tagged

Cat.No. : CTSC-2102H
Product Overview : Human CTSC full-length ORF ( NP_001805.1, 1 a.a. - 463 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 78.2 kDa
AA Sequence : MGAGPSLLLAALLLLLSGDGAVRCD TPANCTYLDLLGTWVFQVGSSGSQR DVNCSVMGPQEKKVVVYLQKLDTAY DDLGNSGHFTIIYNQGFEIVLNDYK WFAFFKYKEEGSKVTTYCNETMTGW VHDVLGRNWACFTGKKVGTASENVY VNTAHLKNSQEKYSNRLYKYDHNFV KAINAIQKSWTATTYMEYETLTLGD MIRRSGGHSRKIPRPKPAPLTAEIQ QKILHLPTSWDWRNVHGINFVSPVR NQASCGSCYSFASMGMLEARIRILT NNSQTPILSPQEVVSCSQYAQGCEG GFPYLIAGKYAQDFGLVEEACFPYT GTDSPCKMKEDCFRYYSSEYHYVGG FYGGCNEALMKLELVHHGPMAVAFE VYDDFLHYKKGIYHHTGLRDPFNPF ELTNHAVLLVGYGTDSASGMDYWIV KNSWGTGWGENGYFRIRRGTDECAI ESIAVAATPIPKL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CTSC cathepsin C [ Homo sapiens ]
Official Symbol : CTSC
Synonyms : CTSC; cathepsin C; PALS, PLS; dipeptidyl peptidase 1; DPP1; cathepsin J; dipeptidyl peptidase I; dipeptidyl transferase; dipeptidyl-peptidase I; JP; HMS; JPD; PLS; CPPI; DPPI; PALS; DPP-I;
Gene ID : 1075
mRNA Refseq : NM_001114173
Protein Refseq : NP_001107645
MIM : 602365
UniProt ID : P53634

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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