• Official Full Name
  • F-box and WD repeat domain containing 4
  • Background
  • This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
  • Synonyms
  • FBXW4; F-box and WD repeat domain containing 4; F box and WD 40 domain protein 4 , SHFM3, split hand/foot malformation (ectrodactyly) type 3; F-box/WD repeat-containing protein 4; dactylin; Fbw4; DAC; F box and WD 40 domain containing protein 4; F box and WD 40 domain protein 4; F box and WD repeat domain containing 4; F box/WD repeat containing protein 4; F box/WD repeat protein 4; F-box and WD-40 domain-containing protein 4; FBW 4; FBWD 4; FBWD4; FBXW 4; FBXW4_HUMAN; OTTHUMP00000059175; SHFM 3; SHSF 3; SHSF3; Split hand/foot malformation (ectrodactyly) type; F-box/WD repeat protein 4; F-box and WD-40 domain protein 4; SHFM3
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBXW4 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBXW4, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FBXW4 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FBXW4 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FBXW4
Source (Host):Species:Human
Product nameRecombinant Human FBXW4 293 Cell Lysate