Recombinant Human FBXW4 Protein, GST-tagged
Cat.No. : | FBXW4-3971H |
Product Overview : | Human FBXW4 full-length ORF (BAG37276.1, 1 a.a. - 412 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 71.72 kDa |
AA Sequence : | MAAAAGEEEEEEEAARESAARPAAG PALWRLPEELLLLICSYLDMRALGR LAQVCRWLRRFTSCDLLWRRIARAS LNSGFTRLGTDLMTSVPVKERVKVS QNWRLGRCREGILLKWRCSQMPWMQ LEDDSLYISQANFILAYQFRPDGAS LNRRPLGVFAGHDEDVCHFVLANSH IVSAGGDGKIGIHKIHSTFTVKYSA HEQEVNCVDCKGGIIVSGSRDRTAK VWPLASGRLGQCLHTIQTEDRVWSF AISPLLSSFVTGTACCGHFSPLRIW DLNSGQLMTHLGSDFPPGAGVLDVM YESPFTLLSCGYDTYVRYWDLRTSV RKCVMEWEEPHDSTLYCLQTDGNHL LATGSSYYGVVRLWDRRQRACLHAF PLTSTPLSSPVYCLRLTTKHLYAAL SYNLHVLDFQNP |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | FBXW4 F-box and WD repeat domain containing 4 [ Homo sapiens ] |
Official Symbol : | FBXW4 |
Synonyms : | FBXW4; F-box and WD repeat domain containing 4; F box and WD 40 domain protein 4 , SHFM3, split hand/foot malformation (ectrodactyly) type 3; F-box/WD repeat-containing protein 4; dactylin; Fbw4; F-box/WD repeat protein 4; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; DAC; FBW4; FBWD4; SHFM3; SHSF3; |
Gene ID : | 6468 |
mRNA Refseq : | NM_022039 |
Protein Refseq : | NP_071322 |
MIM : | 608071 |
UniProt ID : | P57775 |
Products Types
◆ Recombinant Protein | ||
FBXW4-1495R | Recombinant Rhesus Macaque FBXW4 Protein, His (Fc)-Avi-tagged | +Inquiry |
FBXW4-3178M | Recombinant Mouse FBXW4 Protein, His (Fc)-Avi-tagged | +Inquiry |
FBXW4-5778M | Recombinant Mouse FBXW4 Protein | +Inquiry |
FBXW4-30064TH | Recombinant Human FBXW4, His-tagged | +Inquiry |
FBXW4-2889H | Recombinant Human FBXW4 protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
FBXW4-6284HCL | Recombinant Human FBXW4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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