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Recombinant Human FBXW4 Protein, GST-tagged

Cat.No. : FBXW4-3971H
Product Overview : Human FBXW4 full-length ORF (BAG37276.1, 1 a.a. - 412 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 71.72 kDa
AA Sequence : MAAAAGEEEEEEEAARESAARPAAG PALWRLPEELLLLICSYLDMRALGR LAQVCRWLRRFTSCDLLWRRIARAS LNSGFTRLGTDLMTSVPVKERVKVS QNWRLGRCREGILLKWRCSQMPWMQ LEDDSLYISQANFILAYQFRPDGAS LNRRPLGVFAGHDEDVCHFVLANSH IVSAGGDGKIGIHKIHSTFTVKYSA HEQEVNCVDCKGGIIVSGSRDRTAK VWPLASGRLGQCLHTIQTEDRVWSF AISPLLSSFVTGTACCGHFSPLRIW DLNSGQLMTHLGSDFPPGAGVLDVM YESPFTLLSCGYDTYVRYWDLRTSV RKCVMEWEEPHDSTLYCLQTDGNHL LATGSSYYGVVRLWDRRQRACLHAF PLTSTPLSSPVYCLRLTTKHLYAAL SYNLHVLDFQNP
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : FBXW4 F-box and WD repeat domain containing 4 [ Homo sapiens ]
Official Symbol : FBXW4
Synonyms : FBXW4; F-box and WD repeat domain containing 4; F box and WD 40 domain protein 4 , SHFM3, split hand/foot malformation (ectrodactyly) type 3; F-box/WD repeat-containing protein 4; dactylin; Fbw4; F-box/WD repeat protein 4; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; DAC; FBW4; FBWD4; SHFM3; SHSF3;
Gene ID : 6468
mRNA Refseq : NM_022039
Protein Refseq : NP_071322
MIM : 608071
UniProt ID : P57775

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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