FOXM1

  • Official Full Name

    forkhead box M1

  • Overview

    The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
  • Synonyms

    FOXM1; forkhead box M1; MPP2; TGT3; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2; forkhead box protein M1; M-phase phosphoprotein 2; HNF-3/fork-head homolog 11; transcription factor Trident; MPM-2 reactive phosphoprotein 2; forkhead-related protein FKHL16; winged-helix factor from INS-1 cells; Forkhead, drosophila, homolog-like 16; hepatocyte nuclear factor 3 forkhead homolog 11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • GST|His
  • His|SUMO|Myc
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FOXM1-1215H Recombinant Human FOXM1 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Human FOXM1-6152HCL Recombinant Human FOXM1 293 Cell Lysate HEK293 N/A
Human FOXM1-6153HCL Recombinant Human FOXM1 293 Cell Lysate HEK293 N/A
Human FOXM1-5098HF Recombinant Full Length Human FOXM1 Protein, GST-tagged In Vitro Cell Free System GST
Human FOXM1-4464H Recombinant Human FOXM1 Protein, GST-tagged Wheat Germ GST
Human FOXM1-2560H Recombinant Human FOXM1 Protein, GST/His-tagged E.coli GST/His
Human FOXM1-3162H Recombinant Human FOXM1 protein, His-tagged E.coli His
Human FOXM1-1964HFL Recombinant Full Length Human FOXM1 Protein, N-GST/C-His-tagged E.coli GST/His
Human FOxM1-1346H Recombinant Human FOxM1 protein, GST-tagged E.coli GST
Mouse Foxm1-1522M Recombinant Mouse Foxm1 Protein, His-tagged E.coli N-His
Rat Foxm1-7640R Recombinant Rat Foxm1 protein, His & T7-tagged E.coli His/T7
Zebrafish FOXM1-11319Z Recombinant Zebrafish FOXM1 Mammalian Cell His
Chicken FOXM1-2166C Recombinant Chicken FOXM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FOXM1 Related Articles
  • FOXM1 Related Research Area

FOXM1 involved in several pathways and played different roles in them. We selected most pathways FOXM1 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1 associated events during G2/M transition, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleERCC6L;NEK2;MND1;CENPJ;SKA1;LIN52;BANF1;MPEG1.1;RB1
Cell Cycle, MitoticCEP152;LIN37;ARPP19;PMF1;VRK1;ITGB3BP;TUBB4A;TMPO;WAPAL
Cyclin A/B1 associated events during G2/M transitionCDK7;FOXM1
FOXM1 transcription factor networkCKS1B;CENPB;AURKB;CENPA;FOXM1;CHEK2
G2/M TransitionDCTN1A;BORA;CEP63;DYNC1H1;CEP135;LIN37;MAPRE1B;TCTN2;DCTN1
Mitotic G2-G2/M phasesBORA;CDK11A;TUBGCP5;TUBG2;LIN9;TCTN2;NUMA1;TUBGCP2;FOXM1
Polo-like kinase mediated eventsLIN37;LIN52;FOXM1;LIN9
SIDS Susceptibility PathwaysCREM;KCNH2;KCNQ1;KCNJ8;DLX2;SST;SCN3B;CC2D1A;EN1

FOXM1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXM1 itself. We selected most functions FOXM1 had, and list some proteins which have the same functions with FOXM1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNEUROG1;MSH2;ZNF711;RECQL;ZNF223;ZNF225;ADNP2;HIST1H4J;RFX5
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFOXA3;PLAGX;HIF1AL;FOXM1;OVOL3;ETV5B;SOX5;FOXC1;SOX9B
protein bindingH3F3B;PHF17;ZKSCAN3;FNDC3B;RPS11;ATXN7L1;AVPR1A;POLR1B;PRR13
protein kinase bindingKIF14;SHC3;GSTP2;NPM1;EMP2;HIF1A;CD36;POLA1;SUFU
sequence-specific DNA bindingZNF75D;SMAD3A;GSC;PAX2A;ZGPAT;HOXC3A;THRAA;ZNF193;IKZF3
transcription factor activity, sequence-specific DNA bindingMYF6;ETS1;HNF4G;SIM1B;ELF3;TBX24;TSC22D4;TCF7L2;FOXP3
transcription regulatory region DNA bindingPAX2;HDAC1;XRCC6;PROX1;LEF1;CREB3L2;ZNF335;TRP53;FOXI1

FOXM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXM1.

CTNNB1; TCF7L2

Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
Sanabria-Figueroa, E; Donnelly, SM; et al. Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1. MOLECULAR PHARMACOLOGY 87:150-161(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a relationship between the structure and function of FOXM1? 11/28/2022

The structure of FOXM1 determines its ability to bind to DNA and regulate transcription. The study of its structure can help us understand its function and mechanism of action.

What is the correlation between the expression level of FOXM1 and disease? 06/23/2021

Studies have shown that the expression level of FOXM1 is associated with the occurrence and development of a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative diseases.

How to detect FOXM1 expression level? 04/29/2021

The expression level of FOXM1 can be detected by immunohistochemistry, western blot and real-time quantitative PCR.

Does FOXM1 play a role in cancer? 03/29/2021

Studies have shown that the expression level of FOXM1 is upregulated in some cancers, which may promote the occurrence and development of cancer. It could be a potential target for cancer treatment.

What factors should be considered in drug development for FOXM1? 08/13/2020

Drug development for FOXM1 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.

How does FOXM1 interact with other proteins? 01/04/2020

FOXM1 can interact with a variety of other proteins, including transcription factors and proteins in signal transduction pathways. These interactions enable it to regulate processes such as cell proliferation, differentiation, and apoptosis.

Customer Reviews (3)

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Reviews
08/06/2023

    Stable performance in common colorimetric reactions.

    10/01/2022

      The quality of the FOXM1 is consistent and reassuring.

      07/17/2022

        Under the influence of temperature, humidity and light, this protein has good stability and persistence.

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